Results 71 to 80 of about 120,191 (200)

Cysteine peptidases of Eudiplozoon nipponicum: a broad repertoire of structurally assorted cathepsins L in contrast to the scarcity of cathepsins B in an invasive species of haematophagous monogenean of common carp

Parasites & Vectors, 2018
Background Cysteine peptidases of clan CA, family C1 account for a major part of proteolytic activity in the haematophagous monogenean Eudiplozoon nipponicum.
Lucie Jedličková, Hana Dvořáková, Jan Dvořák, Martin Kašný, Lenka Ulrychová, Jiří Vorel, Vojtěch Žárský, Libor Mikeš   +7 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Labelling of cysteine cathepsins in mammalian cells.

, 2020
(A) Lysates from RAW macrophages were treated with 1 μM of the indicated ABPs for 30 min. (B) Live RAW cells were treated with 1 μM of the indicated ABPs for 3 h.
Michele S. Y. Tan (8282568), Ambrosius Snijders (4917097), Mateo I. Sanchez (5309963), Edgar Deu (191711), Dara Davison (8282571), Stephen Howell (132317), Laura E. Edgington-Mitchell (7295483), Bethany M. Anderson (8282574)   +7 more
core   +1 more source

Cysteine cathepsins in human silicotic bronchoalveolar lavage fluids [PDF]

, 2006
Mature, active cysteine cathepsins (CPs) were identified in human inflammatory bronchoalveolar lavage fluid (BALF) supernatants from patients suffering from silicosis by both western blot and surface plasmon resonance analyses.
Perdereau, Céline, Maurel, Marie-Christine, Lalmanach, Gilles, Elisabeth Diot, Hazouard, Eric, Eric Hazouard, Diot, Elisabeth, Godat, Emmanuel, Céline Perdereau, Emmanuel Godat, Gilles Lalmanach, Marie-Christine Maurel   +11 more
core   +1 more source

Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose.

PLoS ONE, 2015
Autophagy is a lysosomal degradative pathway that plays an important role in maintaining cellular homeostasis. We previously showed that the inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism ...
Minjeong Jung, Jaemeun Lee, Hye-Young Seo, Ji Sun Lim, Eun-Kyoung Kim   +4 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Papain-like peptidases: structure, function, and evolution

Biomolecular Concepts, 2013
Papain-like cysteine peptidases are a diverse family of peptidases found in most known organisms. In eukaryotes, they are divided into multiple evolutionary groups, which can be clearly distinguished on the basis of the structural characteristics of the ...
Novinec Marko, Lenarčič Brigita
doaj   +1 more source

Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro

Parasites & Vectors, 2020
Background Naegleria fowleri is a free-living amoeba that causes an opportunistic fatal infection known as primary amoebic meningoencephalitis (PAM) in humans.
Thị Lam Thái, Jung-Mi Kang, Hương Giang Lê, Jinyoung Lee, Won Gi Yoo, Ho-Joon Shin, Woon-Mok Sohn, Byoung-Kuk Na   +7 more
doaj   +1 more source

Mining a cathepsin inhibitor library for new antiparasitic drug leads. [PDF]

PLoS Neglected Tropical Diseases, 2011
The targeting of parasite cysteine proteases with small molecules is emerging as a possible approach to treat tropical parasitic diseases such as sleeping sickness, Chagas' disease, and malaria.
Kenny K H Ang, Joseline Ratnam, Jiri Gut, Jennifer Legac, Elizabeth Hansell, Zachary B Mackey, Katarzyna M Skrzypczynska, Anjan Debnath, Juan C Engel, Philip J Rosenthal, James H McKerrow, Michelle R Arkin, Adam R Renslo   +12 more
doaj   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source