Results 71 to 80 of about 20,394 (270)

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

The Expression and Activity of Cathepsins D, H and K in Asthmatic Airways [PDF]

, 2013
Tumstatin is an anti-angiogenic collagen IV α3 fragment, levels of which are reduced in the airways of asthmatics. Its reduction may be due to the degradation by extracellular matrix (ECM) proteases.
Bao, S, Black, JL, Burgess, JK, Faiz, A, Harkness, L, Oliver, BGG, Tjin, G, Weckmann, M   +7 more
core   +9 more sources

Co-distribution of cysteine cathepsins and matrix metalloproteases in human dentin [PDF]

, 2017
It has been hypothesized that cysteine cathepsin's (CTs) along with matrix metalloproteases (MMPs) may work in conjunction in the proteolysis of mature dentin matrix.
Apolonio, Fabianni, Breschi, Lorenzo, Candia Scaffa, Polliana Mendes, Carrilhon, Marcela Rocha, Curci, Rosa, dos Santos Tersariol, Ivarne Luis, Gobbi, Pietro, Mazzoni, Annalisa, Nascimento, Fabio Dupart, Pashley, David, Pimenta Vidal, Cristina de Mattos, Tjaderhane, Leo   +11 more
core   +2 more sources

Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases

Journal of Atherosclerosis and Thrombosis, 2018
Atherosclerotic cardiovascular disease (ASCVD) is an inflammatory disease characterized by extensive arterial wall matrix protein degradation. Cysteine protease cathepsins play a pivotal role in extracellular matrix (ECM) remodeling and have been implicated in the development and progression of atherosclerosis-based cardiovascular diseases.
Wu, Hongxian, Du, Qiuna, Dai, Qiuyan, Ge, Junbo, Cheng, Xianwu   +4 more
openaire   +3 more sources

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice. [PDF]

PLoS ONE, 2010
Cysteine protease cathepsins are important in extracellular matrix protein degradation, cell apoptosis, and angiogenesis. Mice lacking cathepsins are protected from tumor progression in several animal models, suggesting that the regulation of cathepsin ...
Weifang Yu, Jian Liu, Michael A Shi, Jianan Wang, Meixiang Xiang, Shiro Kitamoto, Bing Wang, Galina K Sukhova, George F Murphy, Gabriela Orasanu, Anders Grubb, Guo-Ping Shi   +11 more
doaj   +1 more source

The Role of Lysosomes in the Cancer Progression: Focus on the Extracellular Matrix Degradation

Acta Biomedica Scientifica, 2021
Lysosomes are multifunctional cell organelles that not only provide degradation of macromolecules by lumenal acid hydrolases, but also contribute in the regulation of cell metabolism, ion homeostasis maintenance, and programmed cell death induction.
I. S. Trukhan, N. N. Dremina, I. A. Shurygina   +2 more
doaj   +1 more source

Co-Emergence of Specialized Endothelial Cells from Embryonic Stem Cells. [PDF]

, 2018
A well-formed and robust vasculature is critical to the health of most organ systems in the body. However, the endothelial cells (ECs) forming the vasculature can exhibit a number of distinct functional subphenotypes like arterial or venous ECs, as well ...
Douglas, Simone A, Fan, Yuhong, Kumar, Ashwath, Lin, Zhiqiang, Madfis, Nicole, McCloskey, Kara E, Platt, Manu O   +6 more
core   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source