Results 91 to 100 of about 20,394 (270)

Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction [PDF]

, 2014
The cysteine protease cathepsin K has been implicated in pathogenesis of cardiovascular disease. We hypothesized that ablation of cathepsin K protects against obesity-associated cardiac dysfunction.
Dolence, Julia, Hua, Yinan, Nair, Sreejayan, Ren, Jun, Shi, Guo-Ping, Zhang, Yingmei   +5 more
core   +1 more source

Nuclear cysteine cathepsin variants in thyroid carcinoma cells [PDF]

Biological Chemistry, 2010
AbstractThe cysteine peptidase cathepsin B is important in thyroid physiology by being involved in thyroid prohormone processing initiated in the follicular lumen and completed in endo-lysosomal compartments. However, cathepsin B has also been localized to the extrafollicular space and is therefore suggested to promote invasiveness and metastasis in ...
Tedelind, Sofia, Poliakova, Kseniia, Valeta, Amanda, Hunegnaw, Ruth, Yemanaberhan, Eyoel Lemma, Heldin, Nils-Erik, Kurebayashi, Junichi, Weber, Ekkehard, Kopitar-Jerala, Nata?a, Turk, Boris, Bogyo, Matthew, Brix, Klaudia   +11 more
openaire   +3 more sources

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Papain-like peptidases: structure, function, and evolution

Biomolecular Concepts, 2013
Papain-like cysteine peptidases are a diverse family of peptidases found in most known organisms. In eukaryotes, they are divided into multiple evolutionary groups, which can be clearly distinguished on the basis of the structural characteristics of the ...
Novinec Marko, Lenarčič Brigita
doaj   +1 more source

A barley cysteine-protease inhibitor reduces teh performance of two aphid species in artificial diets and transgenic arabidopsis plants [PDF]

, 2011
Cystatins from plants have been implicated in plant defense towards insects, based on their role as inhibitors of heterologous cysteine-proteinases. We have previously characterized thirteen genes encoding cystatins (HvCPI-1 to HvCPI-13) from barley ...
A Azzouz, AMR Gatehouse, APO Ribeiro, B Taylor, C Girard, C Novillo, C Rispe, D Michaud, DC Baulcome, F Ortego, F Álvarez-Alfageme, Fernando Álvarez-Alfageme, Félix Ortego, Guy Smagghe, I Dutta, International Aphids Genomics Consortium, Isabel Diaz, J Kehr, L Bordoli, L Oñate-Sanchez, Laura Carrillo, M Martinez, M Martinez, M Martinez, M Martinez, M Pernas, M Pernas, M Porcar, Manuel Martinez, MM Bradford, MS Lantz, MS Nissen, MT Stubbs, N Guex, NC Lawo, Pedro Castañera, PT Cristofoletti, PT Cristofoletti, R Gutierrez-Campos, R Margis, S Shahidi-Noghabi, SE Cowgill, SJ Clough, SK Haq, SN Shahnaz, WS Abbott, Y Rahbé, Y Rahbé, Y Rahbé, Z Abraham   +49 more
core   +3 more sources

Cysteine peptidases of Eudiplozoon nipponicum: a broad repertoire of structurally assorted cathepsins L in contrast to the scarcity of cathepsins B in an invasive species of haematophagous monogenean of common carp

Parasites & Vectors, 2018
Background Cysteine peptidases of clan CA, family C1 account for a major part of proteolytic activity in the haematophagous monogenean Eudiplozoon nipponicum.
Lucie Jedličková, Hana Dvořáková, Jan Dvořák, Martin Kašný, Lenka Ulrychová, Jiří Vorel, Vojtěch Žárský, Libor Mikeš   +7 more
doaj   +1 more source

Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose.

PLoS ONE, 2015
Autophagy is a lysosomal degradative pathway that plays an important role in maintaining cellular homeostasis. We previously showed that the inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism ...
Minjeong Jung, Jaemeun Lee, Hye-Young Seo, Ji Sun Lim, Eun-Kyoung Kim   +4 more
doaj   +1 more source

Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro

Parasites & Vectors, 2020
Background Naegleria fowleri is a free-living amoeba that causes an opportunistic fatal infection known as primary amoebic meningoencephalitis (PAM) in humans.
Thị Lam Thái, Jung-Mi Kang, Hương Giang Lê, Jinyoung Lee, Won Gi Yoo, Ho-Joon Shin, Woon-Mok Sohn, Byoung-Kuk Na   +7 more
doaj   +1 more source

Characterisation and expression analysis of cathepsins and ubiquitin-proteasome genes in gilthead sea bream (Sparus aurata) skeletal muscle [PDF]

, 2015
The proteolytic enzymes involved in normal protein turnover in fish muscle are also responsible for post-mortem softening of the flesh and are therefore potential determinants of product quality. The main enzyme systems involved are calpains, cathepsins,
Capilla Campos, Encarnación, Gutiérrez Fruitós, Joaquín, Johnston, Ian A., Navarro Álvarez, Isabel, Salmerón Salvador, Cristina   +4 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source