Results 81 to 90 of about 120,191 (200)

Structural biology of cysteine cathepsins [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2006
Proteolytic activity is important for normal functioning of an organism andmust be rigorously controlled due to its potential danger. Failure in biological control mechanisms of proteolytic activities may result in a disease. Emerging biological roles of lysosomal cysteine proteases are bringing them in the focus of drug discovery research.
openaire   +1 more source

Cysteine Cathepsin Inhibitors as Anti-Ebola Agents [PDF]

ACS Infectious Diseases, 2016
The recent Ebola virus outbreak in western Africa highlights the need for novel therapeutics that target Ebola virus and other filoviruses. Filoviruses require processing by host cell-derived cysteine cathepsins for productive infection. Here we report the generation of a focused library of cysteine cathepsin inhibitors and subsequent screening to ...
Wouter A, van der Linden, Christopher J, Schulze, Andrew S, Herbert, Tyler B, Krause, Ariel A, Wirchnianski, John M, Dye, Kartik, Chandran, Matthew, Bogyo   +7 more
openaire   +2 more sources

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs

Cell Proliferation, EarlyView.
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh, Lidiia Plotnikova, Teemu Tiukuvaara, Reetta Kälviäinen, Riikka H. Hämäläinen   +4 more
wiley   +1 more source

Protease signalling in cell death: caspases versus cysteine cathepsins [PDF]

, 2007
Proteases were, for a long time, mainly considered as protein degrading enzymes. However, in the last decade this view has changed dramatically, and the focus is now on proteases as signalling molecules.
Turk, Boris, Stoka, Veronika
core   +1 more source

Repositioning Non‐Ablative Fractional Lasers ‐ Molecular and Histological Insights from a scoping review

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Near‐infrared non‐ablative fractional lasers (NAFL) are established for skin rejuvenation and scar treatment and have attracted interest for their expanding therapeutic potential. This scoping review aims to revisit and reposition NAFL within a fluence‐dependent continuum of tissue modulation, based on evidence from 27 studies of lasers ...
Guy Erlich, Uwe Paasch, Kevin Jacobsen, Merete Haedersdal, Uffe Høgh Olesen   +4 more
wiley   +1 more source

Salivary Tick Cystatin OmC2 Targets Lysosomal Cathepsins S and C in Human Dendritic Cells

Frontiers in Cellular and Infection Microbiology, 2017
To ensure successful feeding tick saliva contains a number of inhibitory proteins that interfere with the host immune response and help to create a permissive environment for pathogen transmission.
Tina Zavašnik-Bergant, Robert Vidmar, Andreja Sekirnik, Marko Fonović, Jiří Salát, Lenka Grunclová, Petr Kopáček, Boris Turk, Boris Turk, Boris Turk   +9 more
doaj   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

In Vitro Evaluation of Bond Strength of Adhesive Systems to Dentin and Stability of the Hybrid Layer

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective Contemporary dental adhesives demonstrate strong durable adhesion to enamel while long‐term bonding stability to dentin remains uncertain. This in vitro study aimed to compare conventional dentin conditioning protocols supplemented with protease inhibition and chelate‐based conditioning protocols. Materials and Methods Four groups of
Ana Torres Muñoz, José F. Bartolomé, Carlos Oteo Calatayud, Guillermo J. Pradíes Ramiro, Óscar González‐Martín   +4 more
wiley   +1 more source

Cysteine cathepsins (proteases)—On the main stage of cancer? [PDF]

, 2004
Cysteine cathepsins are involved in degradation of extracellular matrix, facilitating growth, invasion, and metastasis of tumor cells, in tumor angiogenesis, in apoptosis, and in events of inflammatory and immune responses.
Turk, Boris, Turk, Vito, Kos, Janko
core   +1 more source

6‐Month Clinical Evaluation of Reduced Dentin Etching Time Using Universal Adhesives in Noncarious Cervical Lesions: A Double‐Blind Randomized Clinical Trial

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objectives To evaluate the effect of reduced dentin etching time on the clinical performance of two universal adhesive systems in noncarious cervical lesions (NCCLs). Methods A total of 144 NCCLs restorations were randomly placed in 36 participants according to four experimental groups: SUP5 (Scotchbond Universal Plus adhesive [pH ≈2.5–2.7 ...
Mario Felipe Gutiérrez, Natalia Amo‐Nicolás, Alondra Beniscelli‐Vásquez, Romina Aliaga‐Gálvez, Alessandro D. Loguercio   +4 more
wiley   +1 more source