Results 61 to 70 of about 120,191 (200)

Cysteine cathepsins: From structure, function and regulation to new frontiers [PDF]

, 2012
It is more than 50years since the lysosome was discovered. Since then its hydrolytic machinery, including proteases and other hydrolases, has been fairly well identified and characterized. Among these are the cysteine cathepsins, members of the family of
Sun, Tao, Vito Turk, Stoka, Veronika, Tao Sun, Veronika Stoka, Turk, Boris, Turk, Dušan, Renko, Miha, Miha Renko, Dušan Turk, Olga Vasiljeva, Vasiljeva, Olga, Boris Turk, Turk, Vito   +13 more
core   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer

, 2023
Papain-like cysteine proteases are composed of 11 human cysteine cathepsins, originally located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or exopeptidases.
Veronika Stoka, Olga Vasiljeva, Vito Turk, Hiroshi Nakanishi   +3 more
core   +1 more source

Specialized roles for cysteine cathepsins in health and disease [PDF]

Journal of Clinical Investigation, 2010
Cathepsins were originally identified as proteases that act in the lysosome. Recent work has uncovered nontraditional roles for cathepsins in the extracellular space as well as in the cytosol and nucleus. There is strong evidence that subspecialized and compartmentalized cathepsins participate in many physiologic and pathophysiologic cellular processes,
Reiser, Jochen, Adair, Brian, Reinheckel, Thomas   +2 more
openaire   +3 more sources

Design and Synthesis of Cysteine Proteases Inhibitors

Proceedings, 2019
Cysteine proteases belonging to the papain superfamily have been recognized as interesting therapeutic targets for the search for new drugs against infectious tropical diseases such as malaria (falcipain), Chagas’ disease (curtain), leishmaniasis, and ...
Florenci V. Gonzalez
doaj   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S [PDF]

, 2011
A new series of organotelluranes were synthesized and investigated, and the structure-activity relationships in cysteine proteases inhibition were determinated.
ANDRADE, Leandro H., Leandro H. Andrade, Leandro Piovan, ALVES, Marcio F. M., Cunha, Rodrigo Luiz Oliveira Rodrigues [UNIFESP], Rodrigo L.O.R. Cunha, Brömme, Dieter, Márcio F.M. Alves, Alves, Márcio F.M., BROEMME, Dieter, Luiz Juliano, Dieter Brömme, CUNHA, Rodrigo L. O. R., Alves, Marcio Fernando [UNIFESP], Juliano, Luiz [UNIFESP], Cunha, Rodrigo L.O.R., PIOVAN, Leandro, JULIANO, Luiz   +17 more
core   +1 more source

Comparison of Expression of Cathepsins B and L and MMP2 in Endothelial Cells and in Capillary Sprouting in Collagen Gel

The International Journal of Biological Markers, 2004
The lysosomal cysteine proteinases cathepsins B and L are known to play an important role in the invasive growth of tumor cells, but their association with angiogenesis has been less well studied.
S. Caserman, T.T. Lah
doaj   +1 more source

Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.

PLoS ONE, 2015
Motivated by the recent implication of cysteine protease cathepsin L as a potential target for anti-cancer drug development, we used a conditional MycERTAM;Bcl-xL model of pancreatic neuroendocrine tumorigenesis (PNET) to assess the role of cathepsin L ...
Nicola R Brindle, Johanna A Joyce, Fanya Rostker, Elizabeth R Lawlor, Lamorna Swigart-Brown, Gerard Evan, Douglas Hanahan, Ksenya Shchors   +7 more
doaj   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source