Results 41 to 50 of about 10,373 (179)
Бюллетень сибирской медицины, 2020 Aim. To study the level of activity of lysosomal cysteine proteases (cathepsins H, B, L) in blood plasma and fractionated leukocytes (polymorphonuclear and mononuclear) in patients with Alzheimer’s disease in comparison with similar indicators in persons
M. G. Sorokina +3 more
doaj +1 more source
Design and Synthesis of Cysteine Protease Inhibitors
Proceedings, 2017 We have been preparing new dipeptidyl inhibitors against parasitic cysteine proteases cruzain (related to Chagas disease) and rhodesain (related to Sleeping Sickness disease), and against human cathepsins. [...]
Florenci V. Gonzalez
doaj +1 more source
Structural basis for specificity of propeptide-enzyme interaction in barley C1A cysteine peptidases. [PDF]
PLoS ONE, 2012 C1A cysteine peptidases are synthesized as inactive proenzymes. Activation takes place by proteolysis cleaving off the inhibitory propeptide. The inhibitory capacity of propeptides from barley cathepsin L and B-like peptidases towards commercial and ...
Inés Cambra +3 more
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Cysteine cathepsins are essential in lysosomal degradation of α-synuclein. [PDF]
Proc Natl Acad Sci U S A, 2015 Significance Identifying factors that regulate the degradation of α-synuclein, the protein at the center of Parkinson’s disease etiology, is vital in designing therapeutic strategies. This study provides new mechanistic insights into α-synuclein clearance in the lysosome, a cellular site for proteolysis by using purified mouse lysosomes and ...
McGlinchey RP, Lee JC.
europepmc +4 more sources
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease
Frontiers in Cell and Developmental Biology, 2017 Kidney disease is worldwide the 12th leading cause of death affecting 8–16% of the entire population. Kidney disease encompasses acute (short-lasting episode) and chronic (developing over years) pathologies both leading to renal failure.
Pasquale Cocchiaro +14 more
doaj +1 more source
Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety. [PDF]
PLoS ONE, 2011 BACKGROUND: Redox cycling compounds have been reported to cause false positive inhibition of proteases in drug discovery studies. This kind of false positives can lead to unusually high hit rates in high-throughput screening campaigns and require further
Bojana Mirković +3 more
doaj +1 more source
Structural biology of cysteine cathepsins [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2006 Proteolytic activity is important for normal functioning of an organism andmust be rigorously controlled due to its potential danger. Failure in biological control mechanisms of proteolytic activities may result in a disease. Emerging biological roles of lysosomal cysteine proteases are bringing them in the focus of drug discovery research.
openaire +1 more source
Specialized roles for cysteine cathepsins in health and disease [PDF]
Journal of Clinical Investigation, 2010 Cathepsins were originally identified as proteases that act in the lysosome. Recent work has uncovered nontraditional roles for cathepsins in the extracellular space as well as in the cytosol and nucleus. There is strong evidence that subspecialized and compartmentalized cathepsins participate in many physiologic and pathophysiologic cellular processes,
Reiser, Jochen +2 more
openaire +3 more sources
PLoS ONE, 2015 Cathepsins are proteases involved in the ability of parasites to overcome and/or modulate host defenses so as to complete their own lifecycle. However, the mechanisms underlying this ability of cathepsins are still poorly understood.
Waleska Maldonado-Aguayo +3 more
doaj +1 more source