Results 21 to 30 of about 13,297 (156)
A food-grade enzyme preparation with modest gluten detoxification properties. [PDF]
PLoS ONE, 2009 Celiac sprue is a life-long disease characterized by an intestinal inflammatory response to dietary gluten. A gluten-free diet is an effective treatment for most patients, but accidental ingestion of gluten is common, leading to incomplete recovery or ...
Jennifer Ehren +5 more
doaj +1 more source
Papain-like peptidases: structure, function, and evolution
Biomolecular Concepts, 2013 Papain-like cysteine peptidases are a diverse family of peptidases found in most known organisms. In eukaryotes, they are divided into multiple evolutionary groups, which can be clearly distinguished on the basis of the structural characteristics of the ...
Novinec Marko, Lenarčič Brigita
doaj +1 more source
Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids
Angewandte Chemie, EarlyView.Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar +2 more
wiley +2 more sources
Proteases that degrade the biofilm matrix
Zdorovʹe Rebenka, 2020 Biofilms protect bacteria from the action of antibacterial drugs and are one of the mechanisms of antibiotic resistance of infections. Destruction of the bacterial biofilm matrix leads to the release of bacteria and they again become vulnerable to ...
А.Е. Abaturov
doaj +1 more source
An IscS Persulfide Donates the Sulfur for Ribosomal Protein uL16 Thioamidation
Angewandte Chemie, EarlyView.YcaO‐catalyzed thioamidation of the ribosomal subunit protein uL16 is widespread in Pseudomonadota bacteria. We identify the iron–sulfur cluster cysteine desulfurase IscS as the sulfur donor via an IscS persulfide and observe direct IscS–uL16 interactions.
Yanqing Xue +2 more
wiley +2 more sources
Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron
Angewandte Chemie, EarlyView.Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej +20 more
wiley +2 more sources
Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG [PDF]
Proceedings of the National Academy of Sciences, 2004 Pathogenic bacteria have developed complex and diverse virulence mechanisms that weaken or disable the host immune defense system. IdeS (IgG-degrading e nzyme of Streptococcus pyogenes ) is a secreted cysteine endopeptidase from the human pathogen
Wenig, K. +5 more
openaire +3 more sources
Purification and Characterization of a Cysteine Endopeptidase in Cotyledons of Germinated Mung Bean Seeds [PDF]
Plant Physiology, 1990 A cysteine endopeptidase (EC 3.4.22.-) present in cotyledons of mung bean (Vigna radiata) seedlings was purified to homogeneity, as judged by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). This proteinase has an apparent molecular mass of 33 kilodaltons as estimated by SDS-PAGE and belongs to the class of cysteine proteinases as ...
Y, Yamaoka, M, Takeuchi, Y, Morohashi
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Veterinary Research, 2019 Yersinia ruckeri is the causative agent of enteric redmouth disease in salmonids. In fish, the intestine represents an important site of nutrient uptake, host–pathogen interactions, and defense.
Gokhlesh Kumar +3 more
doaj +1 more source
Hormonal Regulation of Expression of Two Cysteine Endopeptidase Genes in Rice Seedlings [PDF]
Plant and Cell Physiology, 1997 Two cDNA probes (pRP60 and pRP80) were used to examine the hormonal regulation of expression of two cysteine endopeptidase genes in germinated whole seeds and de-embryonated seeds of rice. The pRP60 protein is a major rice cysteine endopeptidase named REP-1 that digests rice glutelin, the main seed storage protein.
A, Shintani, H, Kato, T, Minamikawa
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