Results 131 to 140 of about 975,042 (316)

A ferret model demonstrates sustained fibrosis, restrictive physiology, and airway proximalization

npj Regenerative Medicine
Unlike rodents, ferrets have human-like distribution of submucosal glands expressing MUC5B, associated with idiopathic pulmonary fibrosis (IPF). We evaluated ferrets exposed to a single dose of bleomycin (5 U/kg) longitudinally, and found sustained ...
Jacelyn E. Peabody Lever, Qian Li, Nikoleta Pavelkova, Shah S. Hussain, Sayan Bakshi, Janna Q. Ren, Luke I. Jones, Kajal Jadhav, Jared P. Kennemur, Mason Weupe, Javier Campos-Gomez, Liping Tang, Jeremie M. Peabody Lever, Dezhi Wang, Denise D. Stanford, Jeremy B. Foote, Kevin S. Harrod, Harrison Kim, Scott E. Phillips, Steven M. Rowe   +19 more
doaj   +1 more source

Human Genetics Society of Australasia Position Statement: Population-Based Carrier Screening for Cystic Fibrosis [PDF]

, 2014
Martin B. Delatycki, Jo Burke, Louise Christie, Felicity Collins, Michael T. Gabbett, Peter M. George, Eric Haan, Liane Ioannou, Nicole J. Martin, Fiona McKenzie, Peter O’Leary, Nicole Scoble-Williams, Gillian Turner, John Massie   +13 more
openalex   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

ePS03.2 Real-world outcomes in patients (pts) with cystic fibrosis (CF) treated with ivacaftor (IVA): analysis of 2014 US and UK CF registries

, 2016
Yongshen Bai, M. Higgins, N. Volkova, L. Bengtsson, Shuangying Tian, A. Sewall, S. Nyangoma, A. Elbert, D. Bilton   +8 more
openalex   +1 more source

Expression of Pseudomonas aeruginosa Antibiotic Resistance Genes Varies Greatly during Infections in Cystic Fibrosis Patients [PDF]

, 2018
Lois W. Martin, Cynthia L. Robson, Annabelle M. Watts, Andrew Gray, Claire Wainwright, Scott C. Bell, Kay A. Ramsay, Timothy J. Kidd, David W. Reid, Ben Brockway, Iain L. Lamont   +10 more
openalex   +1 more source

Impact of Sex and Age at Lung Transplantation on Long-Term Survival of Patients with Cystic Fibrosis [PDF]

, 2023
D. Razia, Ashraf Omar, Katherine Grief, Rajat Walia, Sofya Tokman   +4 more
openalex   +1 more source

Most costly and prevalent reasons for hospitalization in children with medical complexity in Ontario, Canada

Journal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Children with medical complexity (CMC) have chronic health conditions often associated with functional limitations. CMC comprise 1%–5% of the pediatric population. In Canada, their care accounts for one‐third of pediatric health spending.
Erin Hessey, Thaksha Thavam, Sanjay Mahant, Eyal Cohen, Jingqin Zhu, Francine Buchanan, Teresa To, Peter J. Gill, Ontario Pediatric Hospital Care Study Group (OPHCSG) and the Canadian Paediatric Inpatient Research Network (PIRN), Wenjia Chen, Ronald Cohn, Mairead Green, Matt Hall, Kate Langrish, Colin Macarthur, Myla Moretti, Patricia Parkin, Michelle Quinlan, Ann Bayliss, Ronik Kanani, Sean Murray, Catherine Pound, Mahmoud Sakran, Anupam Sehgal, Sepi Taheri, Gita Wahi   +25 more
wiley   +1 more source

Akt Drives TGF-β-induced Over-secretion of DKK1 and Impairment of Cystic Fibrosis Airway Epithelium Polarity [PDF]

, 2023
Tahir Idris, Michaël Bachmann, Matthew Bacchetta, Bernhard Wehrle‐Haller, Marc Chanson, Mehdi Badaoui   +5 more
openalex   +1 more source

Derivation and validation of the Pediatric Community‐Acquired Pneumonia Severity (PedCAPS) score: A prospective cohort study

Journal of Hospital Medicine, EarlyView.
Abstract Introduction Community‐acquired pneumonia (CAP) is a frequent and costly cause of pediatric emergency department (ED) visits and hospitalizations. Previous prognostic tools for CAP are limited by small samples, single‐center or retrospective designs, lack of generalizability to ED settings, lack of biomarkers, or limited objective data.
Todd A. Florin, Ron Reeder, Lilliam Ambroggio, Richard M. Ruddy, Samir S. Shah, Allison Cator, Matthew J. Lipshaw, Geoffrey A. Capraro, Laura F. Sartori, Amy Y. Cheng, Leah Tzimenatos, Patrick S. Walsh, Claudia R. Morris, Chris A. Rees, Son H. McLaren, Tamar R. Lubell, Chari D. Larsen, Justin Moher, Eileen J. Klein, Shubhada Hooli, Nathan Kuppermann, Pediatric Emergency Care Applied Research Network (PECARN) PedCAPS Investigators   +21 more
wiley   +1 more source

Reduced sialylation of airway mucin impairs mucus transport by altering the biophysical properties of mucin

Scientific Reports
Mucus stasis is a pathologic hallmark of muco-obstructive diseases, including cystic fibrosis (CF). Mucins, the principal component of mucus, are extensively modified with hydroxyl (O)-linked glycans, which are largely terminated by sialic acid.
Elex S. Harris, Hannah J. McIntire, Marina Mazur, Hinnerk Schulz-Hildebrandt, Hui Min Leung, Guillermo J. Tearney, Stefanie Krick, Steven M. Rowe, Jarrod W. Barnes   +8 more
doaj   +1 more source