Results 151 to 160 of about 317,712 (289)

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Free‐Breathing Magnetization Transfer Imaging of the Lung at 0.55 T Using bSTAR

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop a clinically applicable method for magnetization transfer (MT) imaging of the lung at 0.55 T. Methods MT imaging of the chest was explored in healthy volunteers at 0.55 T using a self‐gated 3D half‐radial dual‐echo balanced steady‐state free precession sequence (bSTAR), a 2D multi‐slice gradient echo method (GRE) acquired in
Alexandra Braun, Grzegorz Bauman, Maurice Pradella, Jonathan Röcken, Katrin E. Hostettler, Oliver Bieri   +5 more
wiley   +1 more source

Navigator‐Based Slice Tracking for Multiband Accelerated Liver DWI

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Clinical liver diffusion‐weighted imaging (DWI) suffers from long measurement time and respiratory motion. In this study, we employ a navigator‐based slice tracking technique (NAV) to prospectively compensate for respiratory motion in multiband (MB) accelerated liver DWI.
Ke Zhang, Simon M. F. Triphan, Congcong Fu, Na Zhang, Christian H. Ziener, Mark E. Ladd, Heinz‐Peter Schlemmer, Hans‐Ulrich Kauczor, Oliver Sedlaczek   +8 more
wiley   +1 more source

'The Hero's journey': Narratives on the transition to motherhood with cystic fibrosis. [PDF]

Br J Health Psychol
Haines AJ, Mackenzie L, Honey A, Middleton P.   +3 more
europepmc   +1 more source

Interrelationships among handgrip strength, body composition, physical activity, and quality of life in adults with cystic fibrosis: A cross‐sectional study

Nutrition in Clinical Practice, EarlyView.
Abstract Background In individuals with cystic fibrosis (CF), lean mass and muscle strength are important predictors of clinical outcomes. This study evaluated associations among body composition, handgrip strength, muscle quality, physical activity, and health‐related quality of life in CF. Methods This observational, cross‐sectional study included 27
Benjamin H. Crain, Carly Harris, Moriah P. Bellissimo, Lucia A. Gonzalez Ramirez, Elizabeth A. Ivie, William R. Hunt, Vin Tangpricha, Thomas R. Ziegler, Ryan A. Harris, Jessica A. Alvarez   +9 more
wiley   +1 more source

Addressing the distressing: Pancreatic enzyme replacement therapy mitigates abdominal symptoms and weight loss during chemotherapy for advanced pancreatic cancer: A prospective study

Nutrition in Clinical Practice, EarlyView.
Abstract Background Pancreatic enzyme insufficiency (PEI) contributes to symptom burden and malnutrition in advanced pancreatic cancer (aPC). We aimed to evaluate the impact of pancreatic enzyme replacement therapy (PERT) on symptom burden and weight during chemotherapy.
Pamela N. Klassen, Christina A. Kim, Jessica Kasnik, Michael B. Sawyer, Sunita Ghosh, Vickie Baracos, Vera C. Mazurak   +6 more
wiley   +1 more source

Systematic Review of Nasal Endoscopy Scores in Cystic Fibrosis Patients Treated With Cystic Fibrosis Transmembrane Conductance Regulator Modulators. [PDF]

Pediatr Pulmonol
Gallardo R, Silva BS, Salgado LS, Ribeiro JD, Sakano E.   +4 more
europepmc   +1 more source

Does Total Inferior and Middle Turbinectomy Always Lead to Empty Nose Syndrome?

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Empty Nose Syndrome (ENS) is a rare and paradoxical complication often associated with aggressive turbinate reductions. Previous computational fluid dynamic (CFD) modeling has indicated that distorted nasal airflow patterns could contribute to ENS.
Nidhi Jha, Jed Speers, Ahmad Odeh, Zhenxing Wu, James Mihalich, Lauren E. Gastineau, Bradley Hittle, Bradley A. Otto, Kathleen M. Kelly, Gregory J. Wiet, Kai Zhao   +10 more
wiley   +1 more source

Cutaneous Symptoms of Cystic Fibrosis: A Narrative Review. [PDF]

Clin Cosmet Investig Dermatol
Piątkiewicz M, Olędzka B, Wołkowicz A, Durmaj A, Rudnicka L.   +4 more
europepmc   +1 more source

Diagnosed After Birth—But Detectable Before? A Cohort Study of Prenatal Testing Potential

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To evaluate the yield of prenatal genetic testing in infants with a confirmed genetic diagnosis. Methods We retrospectively reviewed records of infants with a genetic diagnosis who were evaluated using a standardized genetic consult and testing approach. The predicted yield of various prenatal genetic sceening and diagnostic tools in
Allison Schartman, Olivia Woods, Leah Wetherill, Amy M. Breman, Benjamin M. Helm, Kristen Suhrie, Kristyne Stone   +6 more
wiley   +1 more source