Results 161 to 170 of about 486,806 (280)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Theratyping for personalized medicine across cystic fibrosis disease models. [PDF]

Commun Med (Lond)
Bezzerri V, Gunawardena T, Gonska T, Chan AP, Salih R, Lucca F, Moraes TJ, Freedman SD, Cipolli M.   +8 more
europepmc   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Diverse Uses of Lantibiotics: Exploring New Approaches to Combat Antibiotic Resistance

Medicine Advances, EarlyView.
This review illustrates lantibiotics as an alternative therapeutic approach to combat antibiotic resistance, highlighting their diverse sources, including plants, insects, animals, and microorganisms. It further emphasizes their broad therapeutic potential, including antibacterial, antifungal, antiparasitic, antiviral, and anticancer activities (GA ...
Gopalarethinam Janani, Shangavy Pandiarajan, Kunal Biswas, Manickam Rajkumar, Agnishwar Girigoswami, Koyeli Girigoswami   +5 more
wiley   +1 more source

Cystic Fibrosis Newborn Screening: Progress and Perspectives. [PDF]

Int J Neonatal Screen
Sontag MK, McColley SA.
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Research priorities and knowledge gaps in understanding hepatobiliary disease in cystic fibrosis. [PDF]

Hepatol Commun
Debray D, Hunt WR, Bodewes F, Hempstead SE, Peckham D, Petit RS, Philbrick A, Narkewicz M, Sellers ZM, Assis DN, Sathe M, CF Foundation Hepatobiliary Guidelines Committee.   +11 more
europepmc   +1 more source

The Audiologic and Otolaryngologic Phenotype in WHIM Syndrome

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis syndrome) is an ultra‐rare primary immunodeficiency disease caused by autosomal dominant hyperfunctional mutations in the chemokine receptor CXCR4. Otolaryngologists are frequently consulted to evaluate WHIM patients because of recurrent acute ear and sinus ...
Christopher K. Zalewski, H. Jeffrey Kim, Carmen C. Brewer, Sophia Martinez, Caroline Rieger, Elena Cho, David H. McDermott, Philip M. Murphy   +7 more
wiley   +1 more source

Structural and functional impact of cystic fibrosis on endocrine pancreatic innervation. [PDF]

Clin Sci (Lond)
Sun X, Yi Y, Hu S, Novbatova G, Uc A, Ode KL, Engelhardt JF, Norris AW.   +7 more
europepmc   +1 more source

Therapeutic Interventions for Radiation‐Induced Fibrosis in Head and Neck Cancer Patients: A Systematic Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To review and evaluate treatments for radiation‐induced fibrosis (RIF) following head and neck cancer (HNC) therapy. Data sources Medline, Embase.com, Web of Science, and Cochrane Library. Review Methods A systematic review was conducted on the management of HNC RIF using the Preferred Reporting Items for Systematic Reviews and Meta ...
Pooja D. Reddy, Purva Rumde, Vanessa Helou, Mary L. Klem, Matthew E. Spector, Marci L. Nilsen, Kevin J. Contrera   +6 more
wiley   +1 more source