Results 161 to 170 of about 1,132,527 (387)

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

Characteristics of patients with cystic fibrosis-dependent diabetes mellitus in childhood according to the register of patients with cystic fibrosis of the Russian Federation in 2021 [PDF]

, 2023
E. Kondratyeva, A. I. Tlif, A. Voronkova, E. Amelina, N. Kashirskaya, S. Krasovsky, M. Starinova, Тамара Леонидовна Кураева   +7 more
openalex   +1 more source

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Real-world improvement in ultra-low-dose thoracic computed tomography scores, systemic inflammatory markers and patient-reported outcome measures after elexacaftor/tezacaftor/ivacaftor treatment

ERJ Open Research
Background Clinical trials with elexacaftor/tezacaftor/ivacaftor (ETI) in people with cystic fibrosis were associated with significant improvements in % predicted forced expiratory volume in 1 s (FEV1 % pred), sweat chloride, weight and quality of life ...
Hisham Ibrahim, Alexander T. O'Mahony, Kevin F. Deasy, Michael Waldron, Mairead McCarthy, James Dorgan, Claire Fleming, Ciara Howlett, Edel O'Riordan, Yvonne McCarthy, Sarah Twohig, Janice Mansfield, Tamara Vagg, Desmond M. Murphy, Paul O'Regan, Laura Kirwan, Joseph A. Eustace, Owen J. O'Connor, Michael M. Maher, Barry J. Plant   +19 more
doaj   +1 more source

Pharmacogenomics in clinical practice: Biomarker information in Brazilian drug labels

British Journal of Clinical Pharmacology, EarlyView.
This review examines the PGx annotations in package inserts (bulas in Brazilian Portuguese) approved by ANVISA, the Brazilian Health Regulatory Agency, for 19 gene–drug pairs with strong or moderate recommendations for initial dosing alteration in the CPIC (Clinical Pharmacogenetic Implementation Consortion) guidelines and PGx testing required or ...
Guilherme Suarez‐Kurtz
wiley   +1 more source

Characterizing Spatiotemporal Expansion of Pseudomonas aeruginosa Communities in Polymer and Mucin Gel Environments

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Opportunistic colonization and recurring infection by Pseudomonas aeruginosa are substantial risks to lung functionality for people with underlying respiratory diseases such as cystic fibrosis and chronic obstructive pulmonary disease. The complex metabolic and phenotypic adaptations P.
Morgan S. Kim, Glynis L. Kolling, Katharina Ribbeck, Shayn M. Peirce, Jason A. Papin, Roseanne M. Ford   +5 more
wiley   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Natural Products Inhibit Bacterial Growth and Modulate Quorum‐Sensing Systems Las and Rhl in Pseudomonas aeruginosa PA14

Chemistry &Biodiversity, EarlyView.
ABSTRACT Quorum sensing (QS) is a bacterial cell communication system in Pseudomonas aeruginosa, which regulates the production of several virulence factors, including pyocyanin, exoproteases, and biofilm formation. Natural products (NPs) have demonstrated their ability to control QS in different bacteria. This work evaluated the antimicrobial and anti‐
Oswaldo Pablo Martínez‐Rodríguez, Rodolfo García‐Contreras, Rodrigo Aguayo‐Ortiz, Itzel Rubí Yeverino, Carlos A. Fajardo‐Hernández, Albert D. Patiño, Hugo A. Hernández Pérez, Mariel Hernández‐Garnica, Mario Figueroa   +8 more
wiley   +1 more source

Voltage-dependent Block of the Cystic Fibrosis Transmembrane Conductance Regulator Cl- Channel by Two Closely Related Arylaminobenzoates [PDF]

, 1993
The gene defective in cystic fibrosis encodes a Cl- channel, the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is blocked by diphenylamine-2-carboxylate (DPC) when applied extracellularly at millimolar concentrations.
Cohen, B. N., Davidson, N., Lester, H. A., McCarthy, N. A., McDonough, S., Riordan, J. R.   +5 more
core  

Light‐Enabled [2σ + 2π] Cycloadditions of Bicyclo[1.1.0]butanes and Alkenes by Ti‐Salen Photocatalysis

ChemistryEurope, EarlyView.
This study reports an unprecedented Ti(Salen)‐catalyzed [2σ+2π] photocycloaddition of bicyclo[1.1.0]butanes and alkenes, featuring broad substrate scope, excellent functional group tolerance, scalability, and potential pharmaceutical applications. Notably, this work represents the first application of a Ti(Salen) complex as an efficient photoredox ...
Jinping Xing, Dexia Li, Tianxiang Li, Yang Xu, Haosong Ren, Jun Zheng   +5 more
wiley   +1 more source