Results 181 to 190 of about 1,132,527 (387)

Sex‐based differences in heart failure management and outcomes: Insights from the French‐DataHF cohort

European Journal of Heart Failure, EarlyView.
Sex differences in heart failure (HF) management and outcomes in the French‐DataHF cohort. CI, confidence interval; HFH, heart failure hospitalization; HR, hazard ratio; IPW, inverse probability weighting; KM, Kaplan–Meier; LD, loop diuretic; RAS, renin–angiotensin system; RASi, renin–angiotensin system inhibitor.
Guillaume Baudry, Ouarda Pereira, François Roubille, Marc Villaceque, Thibaud Damy, Kevin Duarte, Philippe Tangre, Nicolas Girerd   +7 more
wiley   +1 more source

A ferret model demonstrates sustained fibrosis, restrictive physiology, and airway proximalization

npj Regenerative Medicine
Unlike rodents, ferrets have human-like distribution of submucosal glands expressing MUC5B, associated with idiopathic pulmonary fibrosis (IPF). We evaluated ferrets exposed to a single dose of bleomycin (5 U/kg) longitudinally, and found sustained ...
Jacelyn E. Peabody Lever, Qian Li, Nikoleta Pavelkova, Shah S. Hussain, Sayan Bakshi, Janna Q. Ren, Luke I. Jones, Kajal Jadhav, Jared P. Kennemur, Mason Weupe, Javier Campos-Gomez, Liping Tang, Jeremie M. Peabody Lever, Dezhi Wang, Denise D. Stanford, Jeremy B. Foote, Kevin S. Harrod, Harrison Kim, Scott E. Phillips, Steven M. Rowe   +19 more
doaj   +1 more source

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity. [PDF]

, 2019
Deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is the most frequent mutation causing cystic fibrosis (CF). F508del-CFTR is misfolded and prematurely degraded. Recently thymosin a-1 (
Armirotti, Andrea, Braccia, Clarissa, Cholon, Deborah M, Galietta, Luis JV, Gentzsch, Martina, Guidone, Daniela, Hanrahan, John W, Lukacs, Gergely L, Matthes, Elizabeth, Pedemonte, Nicoletta, Phuan, Puay-Wah, Tomati, Valeria, Veit, Guido, Verkman, Alan S   +13 more
core  

Association between spirometry controlled chest CT scores using computer-animated biofeedback and clinical markers of lung disease in children with cystic fibrosis [PDF]

, 2017
Thomas Kongstad, Kent Green, Frederik Buchvald, Marianne Skov, T. Pressler, Kim G. Nielsen   +5 more
openalex   +1 more source

π‐Expanded Nitrogen‐Cation (N+)‐Doped Polycyclic Aromatic Hydrocarbons: A Review of Intramolecular Cyclization Routes to Benzo[c]Quinolizinium, Triazinium, Pyridoquinazolinium, and Pyridoquinoxalinium Frameworks

European Journal of Organic Chemistry, EarlyView.
This review surveys recent progress in the synthesis of extended aromatic quinolizinium derivatives via intramolecular SNAr and oxidative 6π‐electrocyclization. Conventional thermal approaches are discussed alongside emerging, sustainable activation methods such as electrosynthesis and photochemical processes.
Marine Labro, Cyrille Monnereau, Laure Guy   +2 more
wiley   +1 more source

Reduced sialylation of airway mucin impairs mucus transport by altering the biophysical properties of mucin

Scientific Reports
Mucus stasis is a pathologic hallmark of muco-obstructive diseases, including cystic fibrosis (CF). Mucins, the principal component of mucus, are extensively modified with hydroxyl (O)-linked glycans, which are largely terminated by sialic acid.
Elex S. Harris, Hannah J. McIntire, Marina Mazur, Hinnerk Schulz-Hildebrandt, Hui Min Leung, Guillermo J. Tearney, Stefanie Krick, Steven M. Rowe, Jarrod W. Barnes   +8 more
doaj   +1 more source

Combination antibiotics against Pseudomonas aeruginosa, representing common and rare cystic fibrosis strains from different Irish clinics [PDF]

, 2018
Priya Kapoor, Philip G. Murphy
openalex   +1 more source

Cystic Fibrosis Foundation consensus guidelines for the care of individuals with advanced cystic fibrosis lung disease.

Journal of Cystic Fibrosis, 2020
S. Kapnadak, E. DiMango, D. Hadjiliadis, S. Hempstead, E. Tallarico, J. Pilewski, A. Faro, J. Albright, C. Benden, S. Blair, E. Dellon, Daniel U Gochenour, P. Michelson, B. Moshiree, I. Neuringer, Carl Riedy, T. Schindler, L. Singer, Dave Young, Lauren Vignola, Joan Zukosky, R. Simon   +21 more
semanticscholar   +1 more source

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

Food Frontiers, EarlyView.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima, Parteek Prasher, Mousmee Sharma, Dietrich Büsselberg, Gabriela Figueroa‐González, Octavio Daniel Reyes‐Hernández, Edgar Yebrán Villegas‐Vázquez, Hernán Cortés, Gerardo Leyva‐Gómez, Jesús Herrera‐Bravo, Solomon Habtemariam, Javad Sharifi‐Rad, Monica Butnariu, Cristian Berar, Angela Caunii, William C. Cho   +15 more
wiley   +1 more source

The Human Respiratory Virome in Health and Disease: Interactions, Dysbiosis, and Methodological Challenges

Advanced Genetics, EarlyView.
This article examines how the respiratory virome contributes to health and disease, highlighting its interactions with the host and bacteriome. Key disease associations and present knowledge gaps are outlined. The review discusses challenges in sample collection and preprocessing, and presents future research directions for understanding virome ...
Xiaoxuan Yao, Xiaohui Zou, Bin Cao
wiley   +1 more source