Results 51 to 60 of about 1,122,604 (303)

Effects of propidium monoazide (PMA) treatment on mycobiome and bacteriome analysis of cystic fibrosis airways during exacerbation [PDF]

, 2016
Introduction and Purpose : Propidium monoazide (PMA)-pretreatment has increasingly been applied to remove the bias from dead or damaged cell artefacts, which could impact the microbiota analysis by high-throughput sequencing. Our study aimed to determine
Audebert, Christophe, Delhaes, Laurence, Deschaght, Pieter, Loywick, Alexandre, Merlin, Sophie, Nguyen, Linh Do Ngoc, Van daele, Sabine, Vaneechoutte, Mario, Viscogliosi, Eric   +8 more
core   +3 more sources

Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface

Clinical Microbiology Reviews, 2019
In human pathophysiology, the clash between microbial infection and host immunity contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this phenomenon, wherein a dysfunctional, hyperinflammatory immune response combined with ...
Sankalp Malhotra, D. Hayes, D. Wozniak
semanticscholar   +1 more source

Validating the Data Completeness and Accuracy of the Canadian Cystic Fibrosis Registry

Canadian Respiratory Journal
Conclusion: Our validation of the CCFR demonstrated high accuracy for clinical and demographic variables used in clinical research.
Ranjani Somayaji, Stephanie Y. Cheng, Noma Abdulrahem, Sanja Stanojevic, Paul Eckford, Bradley S. Quon, Elizabeth Cromwell, Albert Faro, Christopher H. Goss, Anne L. Stephenson   +9 more
doaj   +1 more source

CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates

Nature Communications, 2020
Cystic fibrosis (CF) is a lethal genetic disease that is primarily caused by misfolding of the cystic fibrosis transmembrane conductance regulator (CFTR). Here authors show that disease-causing mutations located within the first nucleotide binding domain
Hideki Shishido, Jae Seok Yoon, Zhongying Yang, William R. Skach   +3 more
doaj   +1 more source

Using Serious Games to Motivate Children with Cystic Fibrosis to Engage with Mucus Clearance Physiotherapy [PDF]

, 2012
Positive expiratory pressure (PEP) therapy is an effective method for removing mucus build-up in the lungs of sufferers of chronic lung diseases such as cystic fibrosis (CF).
Day, David, Oikonomou, Andreas
core   +1 more source

Elexacaftor/Tezacaftor/Ivacaftor Efficacy in a Cohort of Italian Patients with CFTR Rare Mutations

International Journal of Translational Medicine
Background: Cystic Fibrosis is an inherited disorder caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene, encoding a chloride and bicarbonate channel widely expressed in epithelia.
Francesca Lucca, Sonia Volpi, Mirco Ros, Benedetta Fabrizzi, Ilaria Meneghelli, Marica Bordicchia, Francesca Buniotto, Alessia Lancini, Cecilia Brignole, Francesca Pauro, Valentino Bezzerri, Marco Cipolli   +11 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes [PDF]

, 2006
Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host ...
A Augarten, A Linden, A Madej, A Trifilieff, AA Ionescu, AE Lovett-Racke, AP Sampson, B Staels, BM Forman, C Andersson, C Hubeau, C Hubeau, DC Jones, E Dagli, F Akbiyik, F McAllister, G Chinetti, H Pall, I Inoue, J Carlstedt-Duke, JD Dignam, JD Tugwood, JH Parmentier, JL Su, JM Shipley, JP Despres, JT Zakrzewski, K Balough, K Beier, KA Kreuzer, LS Nixon, M Ollero, M Roulet, MA Birrell, ME Poynter, N Marx, N Marx, P Delerive, P Greally, P Reineck, PM Farrell, PR Devchand, RB Moss, RB Moss, RB Moss, RU Sorensen, SD Freedman, SM Loitsch, SW Chung, TA Waldmann, TP Dean, TZ Khan, W Wahli, Z Israelian-Konaraki   +53 more
core   +4 more sources

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

Science Translational Medicine, 2019
Increased airway mucus, occurs before infection or structural lung disease in early cystic fibrosis and promotes inflammation. Early changes in cystic fibrosis Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene.
C. Esther, M. Muhlebach, C. Ehre, D. Hill, M. Wolfgang, M. Kesimer, K. Ramsey, K. Ramsey, M. Markovetz, Ian C. Garbarine, M. Forest, Ian Seim, Bryan T Zorn, Cameron B. Morrison, M. Delion, William R. Thelin, D. Villalon, J. Sabater, L. Turkovic, S. Ranganathan, S. Stick, S. Stick, R. Boucher   +22 more
semanticscholar   +1 more source

A retrospective analysis of longitudinal changes in bone mineral content in cystic fibrosis [PDF]

, 2017
Background: We aimed to describe the longitudinal changes in bone mineral content and influencing factors, in children with cystic fibrosis (CF). Methods: One hundred children (50 females) had dual X-ray absorptiometry (DXA) performed.
Ahmed, Syed Faisal, Chirita-Emandi, Adela, Corrigan, Donna, Devenny, Anne, Dryden, Carol, Kyriakou, Andreas, McNeilly, Jane D., Shepherd, Sheila   +7 more
core   +1 more source

Cystic Fibrosis Lung Disease: An Overview

Respiratory care, 2019
Although better insights into the natural course of cystic fibrosis (CF) have led to treatment approaches that have improved pulmonary health and increased the life expectancy of individuals with this disorder, lung disease remains the main cause of ...
N. Turcios
semanticscholar   +1 more source