Results 61 to 70 of about 925,943 (256)
Scientific Reports, 2022 Primary cells isolated from the human respiratory tract are the state-of-the-art for in vitro airway epithelial cell research. Airway cell isolates require media that support expansion of cells in a basal state to maintain the capacity for ...
Rachel Morgan +8 more
doaj +1 more source
Dynamic Risk Prediction Triggered by Intermediate Events Using Survival Tree Ensembles [PDF]
arXiv, 2020 With the availability of massive amounts of data from electronic health records and registry databases, incorporating time-varying patient information to improve risk prediction has attracted great attention. To exploit the growing amount of predictor information over time, we develop a unified framework for landmark prediction using survival tree ...
arxiv
, 2009 Significant volumes of knowledge have been accumulated in recent years linking subtle genetic variations to a wide variety of medical disorders from Cystic Fibrosis to mental retardation. Nevertheless, there are still great challenges in applying this knowledge routinely in the clinic, largely due to the relatively tedious and expensive process of DNA ...
arxiv +1 more source
Interactions between the gut microbiome and host gene regulation in cystic fibrosis
Genome Medicine, 2019 Cystic fibrosis is the most common autosomal recessive genetic disease in Caucasians. It is caused by mutations in the CFTR gene, leading to poor hydration of mucus and impairment of the respiratory, digestive, and reproductive organ functions ...
Gargi Dayama +4 more
semanticscholar +1 more source
Cystic fibrosis and the role of the physiotherapist
South African Journal of Physiotherapy, 1981 Cystic fibrosis is an inherited disease, the major problems being pancreatic malabsorption and progressive respiratory involvement, although numerous other organs may also be involved.
Anne Miot, J. M. Pettifor, I. Reef
doaj +1 more source
Joint Hierarchical Gaussian Process Model with Application to Forecast in Medical Monitoring [PDF]
arXiv, 2014 A novel extrapolation method is proposed for longitudinal forecasting. A hierarchical Gaussian process model is used to combine nonlinear population change and individual memory of the past to make prediction. The prediction error is minimized through the hierarchical design.
arxiv
VX‐659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
New England Journal of Medicine, 2018 BACKGROUND The next‐generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector VX‐659, in triple combination with tezacaftor and ivacaftor (VX‐659–tezacaftor–ivacaftor), was developed to restore the function of Phe508del CFTR protein
J. Davies +20 more
semanticscholar +1 more source
Ion mediated crosslink driven mucous swelling kinetics [PDF]
arXiv, 2015 We present an experimentally guided, multi-phasic, multi-species ionic gel model to compare and make qualitative predictions on the rheology of mucus of healthy individuals (Wild Type) versus those infected with Cystic Fibrosis. The mixture theory consists of the mucus (polymer phase) and water (solvent phase) as well as several different ions: H+, Na+
arxiv
Inflammation in cystic fibrosis: An update
Pediatric Pulmonology, 2018 Inflammation plays a critical role in cystic fibrosis (CF) lung pathology and disease progression making it an active area of research and important therapeutic target.
E. Roesch, D. Nichols, J. Chmiel
semanticscholar +1 more source
A smartphone app for preschool wheezing and reliability of medical history collection
Italian Journal of PediatricsBackground The use of mobile applications helps improving self-management in adolescents with asthma. However, no evidence is available for children with preschool wheezing.
Nicola Ullmann +7 more
doaj +1 more source