Results 61 to 70 of about 1,105,613 (399)

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

Mucin glycosylation and sulphation in airway epithelial cells is not influenced by cystic fibrosis transmembrane conductance regulator expression [PDF]

, 2005
Abnormalities in mucus properties and clearance make a major contribution to the pathology of cystic fibrosis (CF). Our aim was to test the hypothesis that the defects in CF mucus are a direct result of mutations in the CF transmembrane conductance ...
Dell, Anne, Evans, Joanne, Harris, Ann, Leir, Shih-Hsing, Morris, Howard R, Palmai-Pallag, Timea, Parry, Simon   +6 more
core   +1 more source

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source

Cystic Fibrosis Lung Disease: An Overview

Respiratory care, 2019
Although better insights into the natural course of cystic fibrosis (CF) have led to treatment approaches that have improved pulmonary health and increased the life expectancy of individuals with this disorder, lung disease remains the main cause of ...
N. Turcios
semanticscholar   +1 more source

Mechanobiologically Engineered Mimicry of Extracellular Vesicles for Improved Systemic Biodistribution and Anti‐Inflammatory Treatment Efficacy in Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
Triblock copolymer‐reinforced liposomal mimics of extracellular vesicles are engineered with tunable membrane elasticity. A semi‐elastic formulation (Tri‐ARTEX8:2) co‐encapsulating stem cell cytosolic extract and AntagomiR155 targets inflamed joints via the ELVIS effect, reprograms macrophages from M1 to M2, and markedly alleviates collagen‐induced ...
Dahwun Kim, Hwira Baek, Su Yeon Lim, Min Sang Lee, Siyan Lyu, Jihyun Lee, Tun Naw Sut, Marta Gonçalves, Jeong Yi Kang, Joshua A. Jackman, Jin Woong Kim, Ji Hoon Jeong   +11 more
wiley   +1 more source

Microbiology of Cystic Fibrosis Airway Disease

Seminars in Respiratory and Critical Care Medicine, 2019
Although survival of individuals with cystic fibrosis (CF) has been continuously improving for the past 40 years, respiratory failure secondary to recurrent pulmonary infections remains the leading cause of mortality in this patient population.
A. Blanchard, V. Waters
semanticscholar   +1 more source

Allergic bronchopulmonary aspergillosis: diagnostic and treatment challenges [PDF]

, 2016
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder, occurring mostly in asthmatic and cystic fibrosis patients, caused by an abnormal T-helper 2 lymphocyte response of the host to Aspergillus fumigatus antigens.
CINICOLA, BIANCA LAURA, DUSE, MARZIA, Laitano, Rossella, LEONARDI, LUCIA   +3 more
core   +1 more source

Rational Molecular Design of Aniline‐Based Donor‐Acceptor Conducting Polymers Enhancing Ionic Molecular Interaction for High‐Performance Wearable Bioelectronics

Advanced Healthcare Materials, EarlyView.
Organic conducting polymers are crucial for advanced wearable bioelectronic devices. A novel aniline‐based donor‐acceptor conducting polymer is developed via a rational molecular design approach, exhibiting enhanced ionic molecular interactions for highly sensitive and stable wearable pH sensors.
Junning Qian, Ruya Shi, Li Zhang, Wing Cheung Mak   +3 more
wiley   +1 more source

National survey on pediatric respiratory physiotherapy units: primary ciliary dyskinesia and non-CF bronchiectasis

Italian Journal of Pediatrics
Background Currently, there is a lack of data concerning the organization and characteristics of Italian pediatric physiotherapy units for the treatment of patients with chronic lung diseases, especially those with rare conditions such as Primary Ciliary
Beatrice Tani, Nicola Ullmann, Paola Leone, Alessandra Boni, Eugenio Barbieri, Matteo D’Angelo, Sara De Dominicis, Beniamino Giacomodonato, Stefania Monduzzi, Irene Piermarini, Chiara Pizziconi, Beatrice Ferrari, Renato Cutrera   +12 more
doaj   +1 more source

In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis

Science Translational Medicine, 2019
In utero and early postnatal functional rescue of cystic fibrosis transmembrane conductance regulator improves survival in cystic fibrosis ferrets. Tackling cystic fibrosis in the womb Cystic fibrosis (CF) is a multiorgan disease caused by mutations in ...
Xingshen Sun, Y. Yi, Ziying Yan, B. H. Rosen, B. Liang, M. Winter, T. Evans, P. Rotti, Yu Yang, Jaimie S. Gray, Soo‐Yeun Park, Weihong Zhou, Yulong Zhang, S. Moll, Lisa Woody, Dao Tran, Licong Jiang, A. Vonk, J. Beekman, P. Negulescu, F. van Goor, D. Fiorino, K. Gibson-Corley, J. Engelhardt   +23 more
semanticscholar   +1 more source