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Assessment of Interleukin-15 (IL-15) Concentration in Children with Cystic Kidney Disease [PDF]

Biomedicines
Cystic kidney disease is characterized by progressive structural remodeling of renal parenchyma and altered cellular signaling. Inflammatory mediators may contribute to disease biology; however, data on interleukin-15 (IL-15) in pediatric cystic kidney ...
Anna Bogdał, Aleksandra Hop, Elżbieta Świętochowska, Artur Janek, Tomasz Morelewski, Andrzej Badeński, Katarzyna Otrębska, Maria Szczepańska   +7 more
doaj   +3 more sources

The Role of Genetic Testing in Tolvaptan Decision Making: A Case of Atypical Cystic Kidney Disease Associated With CYP24A1 [PDF]

Kidney Medicine
Autosomal dominant polycystic kidney disease (PKD) is a genetically heterogenous group of disorders, most often caused by mutations in polycystin-1 ( PKD1 ) or polycystin-2 ( PKD2 ), for which tolvaptan is the only Food and Drug Administration--approved ...
Mohamed M. Ellabbad, Usama Qamar, Zeeshan Imtiaz, Fouad T. Chebib, Christian Hanna, Navin R. Gupta   +5 more
doaj   +3 more sources

Reactive Oxygen Species in Cystic Kidney Disease [PDF]

Antioxidants
Polycystic kidney disease (PKD) is a rare but significant renal condition with major implications for global acute and chronic patient care. Oxidative stress and reactive oxygen species (ROS) can significantly alter its pathophysiology, clinical outcomes,
Sanat Subhash, Sonya Vijayvargiya, Aetan Parmar, Jazlyn Sandhu, Jabrina Simmons, Rupesh Raina   +5 more
doaj   +3 more sources

Genetic Testing in Cystic Kidney Disease. [PDF]

Kidney360
Genomic investigation is playing an increasing role in the management of cystic kidney diseases, reflecting a broader shift towards precision medicine in Nephrology. Recent updates to the KDIGO Clinical Practice Guideline emphasize diagnostic genomics as a core component of Autosomal Dominant Polycystic Kidney Disease (ADPKD) care in particular ...
Soraru J, Mallett AJ, McCarthy HJ, Mallawaarachchi A.   +3 more
europepmc   +6 more sources

Kidney transcriptome and cystic kidney disease genes in zebrafish [PDF]

Frontiers in Physiology, 2023
Introduction: Polycystic kidney disease (PKD) is a condition where fluid filled cysts form on the kidney which leads to overall renal failure. Zebrafish has been recently adapted to study polycystic kidney disease, because of its powerful embryology and ...
Matthew Koslow, Ping Zhu, Chantal McCabe, Xiaolei Xu, Xiaolei Xu, Xueying Lin   +5 more
doaj   +4 more sources

Genetic diagnosis and prenatal diagnosis of patients with cystic kidney disease in Southwest China [PDF]

BMC Nephrology
Background Cystic kidney disease is a heterogeneous chronic kidney disease. It is often difficult to make a definitive diagnosis based on clinical and ultrasound features alone.
Cong Zhou, Yuanyuan Xiao, Hanbing Xie, Xing Wei, Jing Wang   +4 more
doaj   +2 more sources

Baseline characteristics of the Korean genetic cohort of inherited cystic kidney disease [PDF]

Kidney Research and Clinical Practice, 2023
Background Identifying genetic mutations in individuals with inherited cystic kidney disease is necessary for precise treatment. We aimed to elucidate the genetic characteristics of cystic kidney disease in the Korean population. Methods We conducted a 3-
Jeong Min Cho, Hayne Cho Park, Jin Woo Lee, Hyunjin Ryu, Yong Chul Kim, Curie Ahn, Kyu-Beck Lee, Yeong Hoon Kim, Seungyeup Han, Yaerim Kim, Eun Hui Bae, Hee Gyung Kang, Eujin Park, Kyungjo Jeong, Seoon Kang, Jungmin Choi, Kook-Hwan Oh, Yun Kyu Oh   +17 more
doaj   +2 more sources

Association between lipid-lowering drug targets and the risk of cystic kidney disease: a drug-target Mendelian randomization analysis [PDF]

Renal Failure
Background Evidence regarding the causal relationship between lipid-lowering drugs and cystic kidney disease, including polycystic kidney disease (PKD), was limited.
Zhiwen Lian, Zijie Liang, Qiyan Chen, Chao Xie, Yaozhong Kong   +4 more
doaj   +2 more sources

Network for Early Onset Cystic Kidney Diseases—A Comprehensive Multidisciplinary Approach to Hereditary Cystic Kidney Diseases in Childhood

Frontiers in Pediatrics, 2018
Hereditary cystic kidney diseases comprise a complex group of genetic disorders representing one of the most common causes of end-stage renal failure in childhood.
Jens Christian König, Andrea Titieni, Martin Konrad, The NEOCYST Consortium, C. Bergmann, M. Cetiner, J. Drube, C. Gimpel, J. Göbel, D. Haffner, T. Illig, N. Klopp, J. König, M. Konrad, M. Lablans, M. C. Liebau, S. Lienkamp, C. Okorn, H. Omran, L. Pape, P. Pennekamp, F. Schaefer, B. Schermer, H. Storf, A. Titieni, F. Ückert, S. Weber, W. Ziegler   +27 more
doaj   +3 more sources

[Clinicopathological and molecular features of acquired cystic kidney disease and associated renal cell carcinoma]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Liu H, Guo W, Shi S, He H.
europepmc   +3 more sources