Results 101 to 110 of about 621,963 (341)

Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders. [PDF]

, 2017
PurposePharmacological activation of ocular surface cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels is a potential pro-secretory approach to treat dry eye disorders.
Felix, Christian M, Lee, Sujin, Levin, Marc H, Verkman, Alan S   +3 more
core   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Genetic background of nonmutant Piebald-Virol-Glaxo rats does not influence nephronophthisis phenotypes

International Journal of Nephrology and Renovascular Disease, 2013
Jada Pasquale Yengkopiong, Joseph Daniel Wani LakoJohn Garang Memorial University of Science and Technology, Faculty of Science and Technology, Bor, Jonglei State, Republic of South SudanBackground: Nephronophthisis (NPHP), which affects multiple organs,
Yengkopiong JP, Lako JD
doaj  

Exome Sequencing in Saudi Arabian Pediatric Kidney Disease Single-Center Cohort

Kidney International Reports
Introduction: In pediatric patients, monogenic causes are a significant contributor to kidney disease, ranging from approximately 10% in congenital anomalies of the kidney and urinary tract (CAKUT) to about 55% in renal ciliopathies. Exome sequencing has
Katharina Lemberg, Mohamed A. Shalaby, Elena Zion, Ken Saida, Kirollos Yousef, Ronen Schneider, Nils D. Mertens, Bshara Mansour, Caroline M. Kolvenbach, Lea M. Merz, Korbinian M. Riedhammer, Alina Braun, Selina Hölzel, Seyoung Yu, Kraisoon Lomjansook, Gina Kalkar, Daniel Marchuk, Izzeldin Elmubarak, Gijs A.C. Franken, Shirlee Shril, Sherif El Desoky, Jameela A. Kari, Florian Buerger, Friedhelm Hildebrandt   +23 more
doaj   +1 more source

Congenital Cystic Adenomatoid Malformation of Lung-Rare Case Report [PDF]

Journal of Krishna Institute of Medical Sciences University, 2016
Congenital cystic adenomatoid malformation of lung associated with Cystic dysplasia of kidney, cystic disease of liver with mixed gonadal dysgenesis is rare and is not reported in literature so far. Hence an attempt is made to present this rarest entity.
N. S. Kamakeri
doaj  

Programmatic regulation of macrophage polarization by HAp@MXene nanocomposites to promote bone repair

BMEMat, EarlyView.
HAp@MXene nanocomposites could achieve the programmed regulation of macrophage polarization. They first induce M1 polarization through magnetoelectric induction to combat infection. Subsequently, controlled Ca2+ release drives M2 polarization to promote tissue regeneration. This dual mechanism accelerates bone defect repair and highlights the potential
Laisen Cui, Haina Huang, Yubo Zheng, Jiahao Zhang, Han Hai, Kai Bian, Zhichao Feng, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Shan Lu, Bojun Xie, Ke Gao, Benjie Wei, Ya Liu, Chunhui Sun, Hong Liu, Chao Liu   +16 more
wiley   +1 more source

Ion channels: structural basis for function and disease. [PDF]

, 1996
Ion channels are ubiquitous proteins that mediate nervous and muscular function, rapid transmembrane signaling events, and ionic and fluid balance. The cloning of genes encoding ion channels has led to major strides in understanding the mechanistic basis
Goldstein, SA
core   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

Emerging Therapies for Childhood Polycystic Kidney Disease

Frontiers in Pediatrics, 2017
Cystic kidney diseases comprise a varied collection of hereditary disorders, where renal cysts comprise a major element of their pleiotropic phenotype.
William E. Sweeney, Ellis D. Avner
doaj   +1 more source

Contrast-enhanced ultrasound examination for the assessment of renal perfusion in cats with chronic kidney disease [PDF]

, 2017
Background: Contrast-enhanced ultrasound examination (CEUS) is a functional imaging technique allowing noninvasive assessment of tissue perfusion. Studies in humans show that the technique holds great potential to be used in the diagnosis of chronic ...
Daminet, Sylvie, Duchateau, Luc, Paepe, Dominique, Saunders, Jimmy, Stock, Emmelie, Vandermeulen, Eva, Vanderperren, Katrien   +6 more
core   +2 more sources