Results 81 to 90 of about 621,963 (341)

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Systematic review of transition models for young people with long-term conditions: A report for NHS Diabetes. [PDF]

, 2013
Aims For many young people with Type 1 diabetes, transition from paediatric to adult care can result in a marked deterioration in glycaemic control.
Bagnall, A, Day, R, Kime, NH
core  

Role of contrast-enhanced ultrasound (CEUS) in paediatric practice: an EFSUMB position statement [PDF]

, 2016
The use of contrast-enhanced ultrasound (CEUS) in adults is well established in many different areas, with a number of current applications deemed off-label, but the use supported by clinical experience and evidence.
Cantisani, Vito, Deganello, A., Dietrich, C. F., Duran, C., Franke, D., Gilja, O. H., Harkanyi, Z., Kosiak, W., Miele, Vittorio, Ntoulia, A., Piskunowicz, M., Sellars, M. E., Sidhu, P. S   +12 more
core   +1 more source

Insights into Autosomal Dominant Polycystic Kidney Disease from Genetic Studies.

American Society of Nephrology. Clinical Journal, 2020
Autosomal dominant polycystic kidney disease is the most common monogenic cause of ESKD. Genetic studies from patients and animal models have informed disease pathobiology and strongly support a "threshold model" in which cyst formation is triggered by ...
M. Lanktree, A. Haghighi, Ighli di Bari, Xuewen Song, Y. Pei   +4 more
semanticscholar   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury [PDF]

, 2009
Autosomal dominant polycystic kidney disease (ADPKD) results from mutations in either PKD1 or PKD2 and accounts for 10% of all patients on renal replacement therapy. The kidney disease phenotype is primarily characterized by cyst formation, but there are
Haylor, J.L., McDaid, J.P., Ong, A.C.M., Prasad, S., Tam, F.W.K.   +4 more
core   +2 more sources

Diagnostic Utility of Exome Sequencing for Kidney Disease

New England Journal of Medicine, 2019
BACKGROUND Exome sequencing is emerging as a first‐line diagnostic method in some clinical disciplines, but its usefulness has yet to be examined for most constitutional disorders in adults, including chronic kidney disease, which affects more than 1 in ...
E. Groopman, M. Marasà, Sophia R. Cameron-Christie, S. Petrovski, V. Aggarwal, Hila Milo-Rasouly, Yi-fu Li, Junying Zhang, J. Nestor, P. Krithivasan, Wan Yee Lam, A. Mitrotti, Stacy E. Piva, B. H. Kil, Debanjana Chatterjee, Rachel E. Reingold, Drew Bradbury, Michael DiVecchia, Holly J. Snyder, Xueru Mu, Karla Mehl, Olivia Balderes, D. Fasel, C. Weng, J. Radhakrishnan, P. Canetta, G. Appel, A. Bomback, Wooin Ahn, N. Uy, S. Alam, D. Cohen, R. Crew, G. Dube, Maya K. Rao, S. Kamalakaran, Brett R Copeland, Z. Ren, Joshua Bridgers, C. Malone, C. Mebane, Neha Dagaonkar, B. Fellström, C. Haefliger, S. Mohan, S. Sanna-Cherchi, K. Kiryluk, J. Fleckner, R. March, A. Platt, D. Goldstein, A. Gharavi   +51 more
semanticscholar   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Variable phenotype in HNF1B mutations: extrarenal manifestations distinguish affected individuals from the population with congenital anomalies of the kidney and urinary tract [PDF]

, 2019
Background: Mutations in hepatocyte nuclear factor 1B (HNF1B) have been associated with congenital anomalies of the kidney and urinary tract (CAKUT) in humans. Diabetes and other less frequent anomalies have also been described.
Aguayo Calcena, Aníbal, Ariceta, Gema, Castaño González, Luis Antonio, García Castaño, Alejandro, Madariaga Domínguez, Leire, Martínez Salazar, Rosa   +5 more
core   +2 more sources

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source