Results 31 to 40 of about 317,103 (246)

Imatinib Mesylate Reduces Neurotrophic Factors and pERK and pAKT Expression in Urinary Bladder of Female Mice With Cyclophosphamide-Induced Cystitis

Frontiers in Systems Neuroscience, 2022
Imatinib mesylate is a tyrosine kinase inhibitor that inhibits platelet-derived growth factor receptor (PDGFR)-α, -β, stem cell factor receptor (c-KIT), and BCR-ABL.
Megan Perkins, Beatrice M. Girard, Susan E. Campbell, Grant W. Hennig, Margaret A. Vizzard   +4 more
doaj   +1 more source

Metabolomics Insights Into Pathophysiological Mechanisms of Interstitial Cystitis [PDF]

, 2014
Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or
Fiehn, Oliver, Kim, Jayoung
core   +4 more sources

Notch1 Signaling Contributes to Mechanical Allodynia Associated with Cyclophosphamide-Induced Cystitis by Promoting Microglia Activation and Neuroinflammation

Mediators of Inflammation, 2021
Aims. Notch1 signaling regulates microglia activation, which promotes neuroinflammation. Neuroinflammation plays an essential role in various kinds of pain sensation, including bladder-related pain in bladder pain syndrome/interstitial cystitis (BPS/IC).
Jialiang Chen, Honglu Ding, Bolong Liu, Xiangfu Zhou, Xin Zhou, Zhijun Lin, Fei Yang, Hailun Zhan, Hengjun Xiao   +8 more
doaj   +1 more source

Purinergic receptor mediated calcium signalling in urothelial cells [PDF]

, 2019
Non-neuronal ATP released from the urothelium in response to bladder stretch is a key modulator of bladder mechanosensation. Whilst non-neuronal ATP acts on the underlying bladder afferent nerves to facilitate sensation, there is also the potential for ...
Brierley, Stuart M, Chess-Williams, Russell, Grundy, David, Grundy, Luke, Sellers, Donna J   +4 more
core   +3 more sources

Phenotyping of interstitial cystitis/bladder pain syndrome

International journal of urology, 2019
Interstitial cystitis/bladder pain syndrome is a chronic, potentially debilitating condition characterized by pain perceived to be related to the bladder in conjunction with lower urinary tract symptoms, and includes a wide variety of clinical phenotypes
Y. Akiyama, P. Hanno
semanticscholar   +1 more source

Gut microbiota and interstitial cystitis: exploring the gut-bladder axis through mendelian randomization, biological annotation and bulk RNA sequencing

Frontiers in Immunology
BackgroundSeveral observational studies have indicated an association between interstitial cystitis and the composition of the gut microbiota; however, the causality and underlying mechanisms remain unclear.
Chaowei Fu, Yu Zhao, Xiang Zhou, Jing Lv, Shengkai Jin, Yuhua Zhou, Fengping Liu, Ninghan Feng, Ninghan Feng   +8 more
doaj   +1 more source

Pathophysiology of interstitial cystitis

International journal of urology, 2019
Interstitial cystitis/bladder pain syndrome is a chronic pain syndrome whose causes remains elusive with no generally accepted treatment. A hallmark of functional pain syndromes such as interstitial cystitis/bladder pain syndrome is pain in the absence ...
L. Birder
semanticscholar   +1 more source

Personal cell therapy for interstitial cystitis with autologous stromal vascular fraction stem cells

Therapeutic Advances in Urology, 2019
Background: The objective of this study was to evaluate whether autologous stem-cell-based therapy may mitigate the symptoms of interstitial cystitis. Methods: Stromal vascular fraction (SVF) rich in stem cells and derived from autologous adipose tissue ...
Elliot B. Lander, Mark H. Berman, Jackie R. See   +2 more
doaj   +1 more source

Systematic Review and Meta-Analysis of Intravesical Hyaluronic Acid and Hyaluronic Acid/Chondroitin Sulfate Instillation for Interstitial Cystitis/Painful Bladder Syndrome

Cellular Physiology and Biochemistry, 2016
Background/Aims: To assess the efficacy of intravesical hyaluronic acid (HA) and HA/chondroitin sulfate (CS) instillation in patients with interstitial cystitis/painful bladder syndrome by systematic review and meta-analysis.
Jung-Soo Pyo, Won Jin Cho
doaj   +1 more source

Imatinib Mesylate Reduces Voiding Frequency in Female Mice With Acute Cyclophosphamide-Induced Cystitis

Frontiers in Systems Neuroscience, 2022
Lamina propria interstitial cells that express the tyrosine kinase receptor, platelet-derived growth factor receptor alpha (PDGFRα) may play a role in urinary sensory signaling.
Megan E. Perkins, Beatrice M. Girard, Susan E. Campbell, Margaret A. Vizzard   +3 more
doaj   +1 more source