Results 91 to 100 of about 51,607 (296)

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source

Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway

Drug Design, Development and Therapy, 2017
Kai-Hong Zhao,1 Can Zhang,2 Yue Bai,1 Yan Li,1 Xun Kang,1 Jian-Xin Chen,1 Kun Yao,3 Tao Jiang,4 Xiao-Song Zhong,2 Wen-Bin Li1 1Department of Glioma, 2Clinical Center of Gene And Cell Engineering, Beijing Shijitan Hospital, 3Department of Neurosurgery ...
Zhao KH, Zhang C, Bai Y, Li Y, Kang X, Chen JX, Yao K, Jiang T, Zhong XS, Li WB   +9 more
doaj  

Rational design of a new cytarabine-based prodrug for highly efficient oral delivery of cytarabine

RSC Advances, 2018
To overcome the drawbacks of cytarabine such as bad liposolubility and low bioavailability, we rationally designed a new cytarabine-based prodrug for oral cytarabine delivery, realizing significantly enhanced bioavailability for cancer therapy.
Jing Zhang, Di Zhang, Xu Hu, Ruiling Liu, Zhonghao Li, Yuxia Luan   +5 more
openaire   +3 more sources

A critical review of management of allogeneic transplant‐eligible adults with Ph+ acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Proposed management of newly diagnosed Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukaemia (ALL) in transplant‐eligible patients. Suggested considerations when deciding the treatment pathway available to a newly diagnosed Ph+ ALL patient that would be deemed transplant eligible. Summary Acute lymphoblastic leukaemia (ALL) in 20%–30% of
Naranie Shanmuganathan, Andrew Grigg
wiley   +1 more source

Reformulating acute myeloid leukemia: liposomal cytarabine and daunorubicin (CPX-351) as an emerging therapy for secondary AML

OncoTargets and Therapy, 2018
Despite increasing understanding of the pathobiology of acute myeloid leukemia (AML), outcomes remain dismal particularly for patients over the age of 60 years, a population enriched for therapy-related AML (tAML) and secondary AML (sAML).
E. Chen, A. Fathi, A. Brunner
semanticscholar   +1 more source

Myeloid neoplasm inspired intensive therapy in VEXAS syndrome: A single‐centre experience

British Journal of Haematology, EarlyView.
Summary There is still no standard of care and unmet medical needs in refractory/advanced VEXAS (vacuoles in myeloid progenitors, E1 ubiquitin activating enzyme, X‐linked, autoinflammatory manifestations and somatic) syndrome with or without associated haematological neoplasm.
Maël Heiblig, Adriana Plesa, Juliet Tantot, Yvan Jamilloux, Hélène Labussière‐Wallet, Pierre Sujobert   +5 more
wiley   +1 more source

Low-dose cytarabine to prevent myeloid leukemia in children with Down syndrome: TMD Prevention 2007 study.

Blood Advances, 2018
Approximately 5% to 10% of children with Down syndrome (DS) are diagnosed with transient myeloproliferative disorder (TMD). Approximately 20% of these patients die within 6 months (early death), and another 20% to 30% progress to myeloid leukemia (ML-DS)
M. Flasiński, Kira Scheibke, M. Zimmermann, U. Creutzig, Katarina Reinhardt, F. Verwer, V. de Haas, V. V. D. van der Velden, C. von Neuhoff, C. Zwaan, D. Reinhardt, J. Klusmann   +11 more
semanticscholar   +1 more source

Efficacy and safety of stem cell mobilization with etoposide +cytarabine plus G-CSF in poor mobilizers with relapsed or refractory lymphoma

Frontiers in Immunology
BackgroundAutologous stem cell transplantation (ASCT) is a potentially curative strategy for relapse or refractory(r/r) aggressive lymphoma. However, a proportion of lymphoma patients who are at high risk of mobilization failure fail to mobilize stem ...
Zhijuan Zhu, Xiaofan Li, Xiaofan Li, Xiaohong Yuan, Xianling Chen, Ting Lin, Xiangli Guo, Nainong Li, Nainong Li   +8 more
doaj   +1 more source

Isolated central nervous system relapse in mantle cell lymphoma

eJHaem, EarlyView.
Radu Chiriac, Zofia Gross
wiley   +1 more source

Therapeutic Strategies for Relapsed or Refractory B‐Cell Acute Lymphoblastic Leukemia in Adult Patients: Optimizing the Use of Monoclonal Antibodies

European Journal of Haematology, EarlyView.
ABSTRACT The treatment landscape for relapsed or refractory acute lymphoblastic leukemia (RR ALL) has evolved significantly with the introduction of monoclonal antibodies such as blinatumomab and inotuzumab ozogamicin. These agents have demonstrated remarkable efficacy, achieving high response rates and minimal residual disease (MRD) negativity ...
Antonella Bruzzese, Enrica Antonia Martino, Caterina Labanca, Giulio Caridà, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Noemi Puccio, Antonino Neri, Fortunato Morabito, Ernesto Vigna, Massimo Gentile   +11 more
wiley   +1 more source