Results 81 to 90 of about 67,273 (233)
The power of many: when genetics met yeasts and high‐throughput
Biological Reviews, EarlyView.ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches [PDF]
, 2014 The therapeutic strategies against acute myeloid leukemia (AML) have hardly been modified over four decades. Although resulting in a favorable outcome in young patients, older individuals, the most affected population, do not respond adequately to ...
Azevedo, Maria M. +7 more
core +2 more sources
International Journal of Cancer, EarlyView.Primary central nervous system diffuse large B‐cell lymphoma (PCNS‐DLBCL) lacks an optimal first‐line induction strategy, particularly for older patients and those ineligible for intensive consolidation. In this retrospective cohort of 36 newly diagnosed patients, the rituximab + methotrexate + thiotepa (RMT) regimen as first‐line induction achieved ...
Haotian Wang +10 more
wiley +1 more source
Methotrexate and Cytarabine—Loaded Nanocarriers for Multidrug Cancer Therapy. Spectroscopic Study
Molecules, 2016 Determining the properties of nanoparticles obtained by novel methods and defining the scope of their application as drug carriers has important practical significance.
Danuta Pentak +5 more
doaj +1 more source
Arginine dependence of acute myeloid leukaemia blast proliferation: a novel therapeutic target [PDF]
, 2015 Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and children, yet significant numbers of patients relapse and die of disease. In this study, we identify the dependence of AML blasts on arginine for proliferation.
Beggs, Andrew +13 more
core +1 more source
Interdisciplinary Medicine, EarlyView.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
Influence of variability in starting materials quality on stability of finished drug products: a quality-by-design factor and response [PDF]
, 2012 The use of ill selected excipients in drug formulations can have a significant influence on the overall stability. Therefore, evaluation of chemical and physical excipient compatibility with the API has become a major part in the development of new drug ...
Bauters, Tieneke +5 more
core +1 more source
Myeloid sarcoma presenting as an isolated pancreatic mass in a 3‐year‐old child
JPGN Reports, EarlyView.Abstract Myeloid sarcoma (MS) is an extramedullary tumor of myeloid precursor cells, frequently associated with acute myeloid leukemia (AML), and rarely occurring in isolation. We present a child with obstructive jaundice secondary to a pancreatic head mass.
Jappmann Kaur Monga +7 more
wiley +1 more source
Extended Infusions of Meropenem for Febrile Neutropenia [PDF]
, 2019 Background: Neutropenic fever is an oncologic emergency that requires quick intervention with anti-pseudomonal beta-lactam antibiotics, such as meropenem.
Przybylski, PharmD, Daniel J +1 more
core +1 more source
Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights [PDF]
, 2010 Prognostic markers, such as NPM1, Flt3-ITD, and cytogenetic abnormalities have made it possible to formulate aggressive treatment plans for unfavorable acute myeloid leukemia (AML).
Xiongpeng Zhu, Yuehua Ma, Delong Liu
core +2 more sources