Results 111 to 120 of about 72,150 (302)

Improvements in Real‐World Survival in the Setting of a Recent Paradigm Shift in Acute Myeloid Leukemia Treatment

European Journal of Haematology, EarlyView.
ABSTRACT Therapeutic options for newly diagnosed (ND) acute myeloid leukemia (AML) have increased in recent years, leading to a shift in the treatment paradigm from conventional, intensive chemotherapy toward targeted and less intensive therapy. Since 2017, there has been a surge in FDA approvals for novel therapies, including small molecule inhibitors
Thuy N. Ho, Patrick Willard, Graeme F. Murray, Li Liu, Nolan Wages, Hyun Lee, Keri R. Maher   +6 more
wiley   +1 more source

Host Transcriptomics and Culture‐Independent Testing for the Management of Febrile Neutropenia: Data From an Observational Study Conducted in a Bone Marrow Transplant Unit

European Journal of Haematology, EarlyView.
ABSTRACT Background Managing febrile neutropenia is challenging due to the limited sensitivity of blood culture (BC) and the lack of tools differentiating infectious from non‐infectious fever. T2 magnetic resonance (T2MR) is a culture‐independent system detecting bacteria (T2Bacteria) and yeasts (T2Candida); SeptiCyte RAPID is a host response assay ...
Anna Maria Peri, Andrea S. Henden, Ricky Nelles, Mark D. Chatfield, Patrick N. A. Harris, Glen Kennedy, David L. Paterson   +6 more
wiley   +1 more source

Glucose Metabolism as a Potential Therapeutic Target in Cytarabine-Resistant Acute Myeloid Leukemia

Pharmaceutics
Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need clarification, as well as how to explore these metabolic alterations in therapy.
Joana Pereira-Vieira, Daniela D. Weber, Sâmia Silva, Catarina Barbosa-Matos, Sara Granja, Rui Manuel Reis, Odília Queirós, Young H. Ko, Barbara Kofler, Margarida Casal, Fátima Baltazar   +10 more
doaj   +1 more source

Real‐world experience with CPX‐351 for secondary acute myeloid leukaemia: Comparison with FLAG‐IDA in a propensity score matching analysis

British Journal of Haematology, EarlyView.
Maria Agustina Perusini, Ana Flavia Patiño, Claire Andrews, Sarit E. Assouline, Joseph M. Brandwein, Signy Chow, Gizelle Popradi, David Sanford, Lynn Savoie, Lalit Saini, Bambace Nadia, Dina Khalaf, Andre C. Schuh, Karen Yee, Vikas Gupta, Dawn Maze, Steven M. Chan, Aaron D. Schimmer, Waleed Sabry, Hassan Sibai   +19 more
wiley   +1 more source

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, EarlyView.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

Matched Pair Comparison of Busulfan/Cyclophosphamide/Etoposide (BuCyE) to Carmustine/Etoposide/Cytarabine/Melphalan (BEAM) Conditioning Regimen Prior to Autologous Hematopoietic Cell Transplantation (autoHCT) for Lymphoma [PDF]

, 2014
Marcelo C. Pasquini, Jennifer Le Rademacher, Christopher R. Flowers, Michael Lill, Luciano J. Costa, Tsiporah B. Shore, William P. Vaughan, Michael Craig, César O. Freytes, Thomas C. Shea, Mitchell E. Horwitz, Joseph W. Fay, Shin Mineishi, Damiano Rondelli, James R. Mason, Vijay Reddy, Ira Braunschweig, Weiyun Z. Ai, Elizabeth Armstrong, Angela Smith, Cathy Zhao, Agnes Elekes, Jeanette Carreras, Kazunobu Kato, Edmund K. Waller   +24 more
openalex   +1 more source

Philadelphia chromosome‐positive acute lymphoblastic leukaemia in children and adolescents: A changing treatment landscape and a methodological challenge

British Journal of Haematology, EarlyView.
Adriana Balduzzi, Maria Grazia Valsecchi, Thai Hoa Tran, Jan Zuna, Veronica Leoni, Gunnar Cario, Grazia Fazio, Virginie Gandemer, Sarah K. Tasian, Inge M. van der Sluis, Nicolò Peccatori, Rosanna Parasole, Stefania Monterisi, Mignon L. Loh, Meenakshi Devidas, Stephen P. Hunger, John A. Kairalla, Paola De Lorenzo, Lewis B. Silverman, Andrea Biondi   +19 more
wiley   +1 more source

Patient‐Reported Oral Symptoms and Their Impact on Well‐Being After Haematopoietic Cell Transplantation

Oral Diseases, EarlyView.
ABSTRACT Objective Oral complications may negatively influence outcomes of haematopoietic cell transplantation (HCT). A comprehensive view of oral symptoms and symptom burden post‐HCT is lacking. This study aimed to determine the prevalence, severity, and temporal relationships of oral symptoms and their impact on well‐being in the early post‐HCT phase.
Kristina Skallsjö, Michael T. Brennan, Bengt Hasséus, Jenny Öhman, Judith E. Raber‐Durlacher, Marie‐Charlotte D. N. J. M. Huysmans, Alexa M. G. A. Laheij, Stephanie J. M. van Leeuwen, Allan J. Hovan, Karin Garming Legert, Scott Isom, David M. Kline, Nicole M. A. Blijlevens, Jan‐Erik Johansson, Inger von Bültzingslöwen   +14 more
wiley   +1 more source

Enhanced Antitumor Efficacy of Cytarabine and Idarubicin in Acute Myeloid Leukemia Using Liposomal Formulation: In Vitro and In Vivo Studies

Pharmaceutics
Background: Acute myeloid leukemia (AML) is the most common type of acute leukemia among adults with the recommend therapy of combination of cytarabine and idarubicin in the induction phase.
Chunxia Zhu, Yang Liu, Xiaojun Ji, Yaxuan Si, Xianhao Tao, Xiaohua Zhang, Lifang Yin   +6 more
doaj   +1 more source

Utility of Cytochemical and Flow Cytometry Detection of Alkaline Phosphatase for Differential Diagnosis of CD34+ Acute Leukaemia in Canines

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Alkaline phosphatase (ALP) enzymatic activity has been proposed as a marker for distinguishing canine acute leukaemia (AL) subtypes (i.e., myeloid vs. lymphoid). However, ALP enzymatic activity has not been fully evaluated in CD34+ AL. Determine whether ALP enzymatic activity can differentiate CD34+ AL subtypes in dogs and distinguish CD34+ AL
Megan Aalto, Janna Yoshimoto, Jillian Nolan, Kenzie Olsen, Dylan Ammons, Emily Rout, Anne C. Avery, R. Adam Harris   +7 more
wiley   +1 more source