Results 141 to 150 of about 87,437 (368)

Decitabine Compared with Low-Dose Cytarabine for the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia: A Pilot Study of Safety, Efficacy, and Cost-Effectiveness

Advances in Hematology, 2015
Introduction. The incidence of Acute Myeloid Leukemia (AML) increases progressively with age and its treatment is challenging. This prospective case control study was undertaken to compare the safety, efficacy, and cost-effectiveness of decitabine with ...
Linu A. Jacob, S. Aparna, K. C. Lakshmaiah, D. Lokanatha, Govind Babu, Suresh Babu, Sandhya Appachu   +6 more
doaj   +1 more source

Long-Term Skin Allograft Survival Elicited by a Finite Treatment with Antilymphocyte Serum Combined with Cytarabine [PDF]

, 1970
R. J. Perper, R. E. Monovich, B. E. Bowersox   +2 more
openalex   +1 more source

Low-dose cytarabine to prevent myeloid leukemia in children with Down syndrome: TMD Prevention 2007 study.

Blood Advances, 2018
Approximately 5% to 10% of children with Down syndrome (DS) are diagnosed with transient myeloproliferative disorder (TMD). Approximately 20% of these patients die within 6 months (early death), and another 20% to 30% progress to myeloid leukemia (ML-DS)
M. Flasiński, Kira Scheibke, M. Zimmermann, U. Creutzig, Katarina Reinhardt, F. Verwer, V. de Haas, V. V. D. van der Velden, C. von Neuhoff, C. Zwaan, D. Reinhardt, J. Klusmann   +11 more
semanticscholar   +1 more source

Machine Learning‐Based Predictive Modeling Maximizes the Efficacy of mTOR/p53 Co‐Targeting Therapy Against AML

Cancer Science, EarlyView.
Although mTOR inhibitors show limited clinical efficacy against AML, this study demonstrates that combining mTOR inhibition with TP53 activation enhances anti‐leukemic effects. We also developed a gene scoring system (Rapa‐11) predicting rapamycin sensitivity and showed that monocytic AMLs with wild‐type TP53 and low Rapa‐11 scores are highly ...
Jingmei Li, Emi Sugimoto, Keita Yamamoto, Yutong Dai, Wenyu Zhang, Yu‐Hsuan Chang, Jakushin Nakahara, Tomohiro Yabushita, Toshio Kitamura, Sung‐Joon Park, Kenta Nakai, Susumu Goyama   +11 more
wiley   +1 more source

Stromal cell effects on melanoma cell drug response [PDF]

, 2013
Thesis (M.A.)--Boston UniversityObjective: Melanoma is currently one of the deadliest forms of skin disease in the United States. However in the past decade there have been significant advances in treatment.
Della Penna, Greg
core   +1 more source

Treatment of juvenile chronic myeloid leukemia with sequential subcutaneous cytarabine and oral mercaptopurine [PDF]

, 1977
JS Lilleyman, JF Harrison, JA Black
openalex   +1 more source

COL6A2: A Key Survival‐Related Gene and Restricting Antitumor Immunity in Glioblastoma

Cancer Science, EarlyView.
Targeting COL6A2 enhances the activation of dendritic cells and anti‐tumor immunity in glioblastoma multiforme (GBM). COL6A2 may act as a key mediator of immune escape in GBM and a potential target for combinatorial immunotherapeutic strategies. ABSTRACT Glioblastoma (GBM) is an aggressive malignant brain tumor, characterized by a poor prognosis and a ...
Zhenkun Yang, Jiao Meng, Daxing Xu, Jie Li, Fan Kong, Ying Yin, Bo Zhang, Yunhui Pan, Jiantong Jiao, Xinyi Jiang, Zhening Pu   +10 more
wiley   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

Glucose Metabolism as a Potential Therapeutic Target in Cytarabine-Resistant Acute Myeloid Leukemia

Pharmaceutics
Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need clarification, as well as how to explore these metabolic alterations in therapy.
Joana Pereira-Vieira, Daniela D. Weber, Sâmia Silva, Catarina Barbosa-Matos, Sara Granja, Rui Manuel Reis, Odília Queirós, Young H. Ko, Barbara Kofler, Margarida Casal, Fátima Baltazar   +10 more
doaj   +1 more source

Bispecific antibody therapy in CNS myeloma: Early evidence from a multicentre cohort

British Journal of Haematology, EarlyView.
Alexandra Noveihed, Samer Al Hadidi, Meera Mohan, Mansi R. Shah   +3 more
wiley   +1 more source