Results 11 to 20 of about 42,251 (222)

Antileukemic Potential of Sodium Caseinate in Cytarabine-Resistant HL60-CR50 Human Leukemia Cells [PDF]

Molecules
Chemoresistance is the leading cause of mortality in cancer patients. The poor clinical prognosis and limited therapeutic options for acute myeloid leukemia (AML) patients demand the development of new therapeutic strategies capable of overcoming ...
Edelmiro Santiago-Osorio, Daniel Romero-Trejo, Víctor Manuel Macías-Zaragoza, Katia Michell Rodríguez-Terán, Víctor Manuel Mendoza-Núñez, Edith Sierra-Mondragón, Ernesto Romero-López, Lorena Shira, David Hernández-Álvarez, Itzen Aguiñiga-Sánchez   +9 more
doaj   +2 more sources

Effect of Rutin on Cytarabine-Associated Pulmonary Oedema and Oxidative Stress in Rats [PDF]

Anais da Academia Brasileira de Ciências, 2020
Cytarabine is effectively used in the treatment of adult acute leukemia, but it has a dose-limiting side effect of fatal pulmonary oedema because it increases the vascular permeability of the alveolar capillaries.
ASLI O. BILGIN, RENAD MAMMADOV, BAHADIR SULEYMAN, EDHEM UNVER, FATIH OZCICEK, MEHMET SOYTURK, FERDA K. CIMEN, NEZAHAT KURT, HALIS SULEYMAN   +8 more
doaj   +1 more source

Interaction of Lipophilic Cytarabine Derivatives with Biomembrane Model at the Air/Water Interface

Membranes, 2022
Cell membrane models are useful for obtaining molecular-level information on the interaction of biologically active molecules whose activity is believed to depend also on their effects on the membrane.
Jhon Fernando Berrio Escobar, Cristiano Giordani, Stefano Russo, Francesco Castelli, Maria Grazia Sarpietro   +4 more
doaj   +1 more source

The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

HemaSphere, 2022
Resistance to cytarabine is a key problem in the treatment of acute myeloid leukemia (AML). To understand the molecular biology of resistance to cytarabine, a viability-based chemosensitizer screen was utilized. We screened synthetic lethal targets using
Miriam Rehberger, Jonas A. Schäfer, Anna-Maria Krampitz, Anne Catherine Bretz, Lukas Jost, Torsten Haferlach, Thorsten Stiewe, Andreas Neubauer   +7 more
doaj   +1 more source

A biophysical approach of cytarabine anticancer drug insights into human serum albumin and checkpoint kinase 1

Results in Chemistry, 2023
The present studies used biophysical techniques to examine the binding interaction mechanism of cytarabine anticancer drugs with human serum albumin (HSA) and checkpoint kinase 1.
Manoharan Rupavarshini, Subramani Karthikeyan, Sundaramoorthy Anandh, Anitha Ramamoorthi, Suganya Ramakrishnamurthy, Ganesan Bharanidharan, Prakasarao Aruna, Rajendiran Mangaiyarkarasi, Shanmugavel Chinnathambi, Ganesh N. Pandian, Singaravelu Ganesan   +10 more
doaj   +1 more source

The histological changes induced by Cytarabine on rabbits livers (with and without vitamin E administration) [PDF]

Iraqi Journal of Veterinary Sciences, 2020
The present study was intended to determine the histological changes induced by Cytarabine drug on the structure of rabbit's livers and the protective effects of vitamin E on these histological changes.
Saif Al-Jammas, Ayad Al-Saraj
doaj   +1 more source

The Efficacy and Safety of Cytarabine on Newly Diagnosed Primary Central Nervous System Lymphoma: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2020
Background: The role of cytarabine on newly diagnosed primary central nervous system lymphoma (PCNSL) remains controversial. The present study mainly aimed to assess the efficacy and safety of cytarabine in the induction treatment of PCNSL.Methods: We ...
Xiaohong Zheng, Shoubo Yang, Feng Chen, Si Wu, Wenbin Li   +4 more
doaj   +1 more source

Intermediate-dose cytarabine is an effective therapy for adults with non-Langerhans cell histiocytosis

Orphanet Journal of Rare Diseases, 2022
Background Non-Langerhans cell histiocytosis, including Erdheim–Chester disease (ECD), Rosai–Dorfman disease (RDD), indeterminate cell histiocytosis (ICH), and unclassified histiocytosis, is a rare disorder lacking a standard treatment strategy.
Ting Liu, Hua-cong Cai, Hao Cai, Miao Chen, Wei Zhang, Jian Li, Dao-bin Zhou, Xin-xin Cao   +7 more
doaj   +1 more source

Orally Administered, Biodegradable and Biocompatible Hydroxypropyl–β–Cyclodextrin Grafted Poly(methacrylic acid) Hydrogel for pH Sensitive Sustained Anticancer Drug Delivery

Gels, 2022
In the current study, a pH sensitive intelligent hydroxypropyl–β–cyclodextrin-based polymeric network (HP-β-CD-g-MAA) was developed through a solution polymerization technique for site specific delivery of cytarabine in the colonic region.
Nighat Batool, Rai Muhammad Sarfraz, Asif Mahmood, Muhammad Zaman, Nadiah Zafar, Ahmad Salawi, Yosif Almoshari, Meshal Alshamrani   +7 more
doaj   +1 more source

Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis

Cell Death and Disease, 2022
Venetoclax plus cytarabine therapy is approved for elderly acute myeloid leukemia (AML) patients and needs further improvement. We studied the mechanisms of venetoclax plus cytarabine treatment and searched for a third agent to enhance their effects ...
Jingyi Zhang, Yuetong Wang, Chujie Yin, Ping Gong, Zhenwei Zhang, Linxiang Zhao, Samuel Waxman, Yongkui Jing   +7 more
doaj   +1 more source