Results 21 to 30 of about 45,546 (194)
Pharmaceutics, 2022 Acute myeloid leukemia (AML) is a heterogeneous disease characterized by remarkable toxicity and great variability in response to treatment. Plenteous pharmacogenetic studies have already been published for classical therapies, such as cytarabine or ...
Álvaro Pinto-Merino +7 more
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Frontiers in Pharmacology, 2023 Low-dose cytarabine (LDAC) is a standard therapy for elderly acute myeloid leukemia (AML) patients unfit for intensive chemotherapy. While high doses of cytarabine induce cytotoxicity, the precise mechanism of action of LDAC in AML remains elusive.
Tomislav Smoljo +6 more
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Sari Pediatri, 2016 Latar belakang. Pengobatan leukemia mieloblastik akut (LMA) telah banyak mengalami kemajuan. Di negara maju, keberhasilan pengobatan sudah mencapai 65%, sementara di Indonesia diperkirakan masih di bawah 10%.
Eddy Supriyadi +2 more
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Cancer Medicine, 2023 Objective We aimed to retrospectively discern the heterogeneity of outcomes from clinicopathological characteristics and next‐generation sequencing (NGS) data in adult patients with NPM1‐mutated (NPM1mut) acute myeloid leukemia (AML) induced with ...
Biao Wang +4 more
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Frontiers in Cell and Developmental Biology, 2020 Short linear motifs (SLiMs) located in disordered regions of multidomain proteins are important for the organization of protein–protein interaction networks.
Mateusz Putyrski +12 more
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Physiological and histological effects of apigenin and luteolin on Cytarabine injected rats
مجلة بغداد للعلومThe present study was undertaken to study the effect of apigenin and luteolin on physiological and histological changes in rats treated with cytarabine drugs.
Ghada A. Taqa, Omar N. Sultan
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Effects of immunoregulatory drugs on human peripheral blood T lymphocytes function in vitro [PDF]
Archive of Oncology, 2002 BACKGROUND: The purpose of the study was to evaluate the mode of action of different immunoregulatory drugs in lymphocyte proliferation and activation METHODS: The drugs studied were prednisolone (PRED), cyclosporin A (CsA) the recombination of PRED and ...
Hatzistilianou Marija +6 more
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Journal of Lipid Research, 2023 Chemotherapy-induced cachexia causes severe metabolic abnormalities independently of cancer and reduces the therapeutic efficacy of chemotherapy. The underlying mechanism of chemotherapy-induced cachexia remains unclear.
Mi-Rae Park +9 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Exploring the ocean for new drug developments: Marine pharmacology
Journal of Pharmacy and Bioallied Sciences, 2016 Disease ailments are changing the patterns, and the new diseases are emerging due to changing environments. The enormous growth of world population has overburdened the existing resources for the drugs. And hence, the drug manufacturers are always on the
Harshad Malve
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