Results 11 to 20 of about 67,273 (233)

Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis

open access: yesCell Death and Disease, 2022
Venetoclax plus cytarabine therapy is approved for elderly acute myeloid leukemia (AML) patients and needs further improvement. We studied the mechanisms of venetoclax plus cytarabine treatment and searched for a third agent to enhance their effects ...
Jingyi Zhang   +7 more
doaj   +1 more source

Cytarabine-Induced Encephalitis

open access: yesJournal of the Belgian Society of Radiology, 2021
Teaching Point: Central nervous system adverse effects of cytarabine treatment include aseptic meningitis, myelopathy, and more rarely, encephalopathy, seizures, and cerebellar dysfunction.
Christine Lenfant   +2 more
doaj   +1 more source

Long-term follow-up results of cytarabine-containing chemotherapy for acute promyelocytic leukemia [PDF]

open access: yesThe Korean Journal of Internal Medicine, 2022
Background/Aims We evaluated the feasibility and long-term efficacy of the combination of cytarabine, idarubicin, and all-trans retinoic acid (ATRA) for treating patients with newly diagnosed acute promyelocytic leukemia (APL).
Young Hoon Park   +36 more
doaj   +1 more source

Optimizing survival outcomes with post-remission therapy in acute myeloid leukemia. [PDF]

open access: yes, 2019
Optimization of post-remission therapies to maintain complete remission and prevent relapse is a major challenge in treating patients with acute myeloid leukemia (AML).
Chan, Steven M   +4 more
core   +1 more source

Repurposing Cytarabine for Treating Primary Effusion Lymphoma by Targeting Kaposi’s Sarcoma-Associated Herpesvirus Latent and Lytic Replications

open access: yesmBio, 2018
Oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically linked to primary effusion lymphoma (PEL), an aggressive and nontreatable malignancy commonly found in AIDS patients.
Marion Gruffaz   +7 more
doaj   +1 more source

High dose cytarabine induced myopericarditis: When the heart debilitates but the fight against cancer must be strong

open access: yesIatreia, 2022
Knowledge about cytarabine induced cardiotoxicity is scarce. We present the clinical case of a 51-year-old patient with past medical history of Acute Myeloid Leukemia managed with high doses of cytarabine and who developed acute myopericarditis as a ...
Villa-Saldarriaga, María P   +3 more
doaj   +1 more source

p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia [PDF]

open access: yes, 2011
Suppression of apoptosis by TP53 mutation contributes to resistance of acute myeloid leukemia (AML) to conventional cytotoxic treatment. Using differentiation to induce irreversible cell cycle exit in AML cells could be a p53-independent treatment ...
Anjali Advani   +15 more
core   +2 more sources

Treatment of Adult Patients with Relapsed/Refractory B-Cell Philadelphia-Negative Acute Lymphoblastic Leukemia [PDF]

open access: yes, 2019
The majority of adult patients affected by B-cell acute lymphoblastic leukemia (B-ALL) will relapse after an initial response, while approximately 20% will display primary resistant disease. Patients suffering from relapsed/refractory B-ALL have a very
Lanza, Francesco   +2 more
core   +1 more source

Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity

open access: yesBMC Cancer, 2018
Background The addition of high-dose cytarabine to the treatment of mantle cell lymphoma (MCL) has significantly prolonged survival of patients, but relapses are common and are normally associated with increased resistance.
Catja Freiburghaus   +8 more
doaj   +1 more source

Histological Effects of Cytarabine on Liver and Buccal Mucosa in Mice [PDF]

open access: yesAl-Rafidain Dental Journal, 2020
Aims : This study aimed to investigate the histopathological effect of cytarabine drug on liver and buccal mucosa in mice. Materials and Methods: Sixteen male albino mice were randomly assigned to two experimental groups and housed as eight animals /cage
Ghasaq A. Dawood   +2 more
doaj   +1 more source

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