Results 41 to 50 of about 74,294 (341)

Cytarabine and clofarabine after high‐dose cytarabine in relapsed or refractory AML patients [PDF]

American Journal of Hematology, 2012
AbstractClofarabine has been shown to be effective in AML patients, either as single agent or, mainly, in association with intermediate dose cytarabine. Based on these reports, we conducted a preliminary study combining clofarabine and intermediate dose cytarabine in AML patients who relapsed or failed to respond to at least two induction therapies. We
Scappini B, Gianfaldoni G, Caracciolo F, Mannelli F, Biagiotti C, Romani C, Pogliani EM, Simonetti F, Borin L, Fanci R, Cutini I, Longo G, Susini MC, Angelucci E, Bosi A   +14 more
openaire   +4 more sources

The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes

Haematologica, 2019
Although cytarabine has been widely considered as one of the chemotherapy drugs for high-risk myelodysplastic syndromes (MDS), the overall response rate is only approximately 20-30%.
Peipei Lin, Yanling Ren, Xiaomei Yan, Yingwan Luo, Hua Zhang, Meenu Kesarwani, Jiachen Bu, Di Zhan, Yile Zhou, Yuting Tang, Shuanghong Zhu, Weilai Xu, Xinping Zhou, Chen Mei, Liya Ma, Li Ye, Chao Hu, Mohammad Azam, Wei Ding, Jie Jin, Gang Huang, Hongyan Tong   +21 more
doaj   +1 more source

Inhibition of mTOR-dependent autophagy sensitizes leukemic cells to cytarabine-induced apoptotic death.

PLoS ONE, 2014
The present study investigated the role of autophagy, a cellular self-digestion process, in the cytotoxicity of antileukemic drug cytarabine towards human leukemic cell lines (REH, HL-60, MOLT-4) and peripheral blood mononuclear cells from leukemic ...
Mihajlo Bosnjak, Biljana Ristic, Katarina Arsikin, Aleksandar Mircic, Violeta Suzin-Zivkovic, Vladimir Perovic, Andrija Bogdanovic, Verica Paunovic, Ivanka Markovic, Vladimir Bumbasirevic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic   +11 more
doaj   +1 more source

FDA Approval Summary: (Daunorubicin and Cytarabine) Liposome for Injection for the Treatment of Adults with High-Risk Acute Myeloid Leukemia

Clinical Cancer Research, 2018
On August 3, 2017, the FDA granted regular approval to Vyxeos (also known as CPX-351; Jazz Pharmaceuticals), a liposomal formulation of daunorubicin and cytarabine in a fixed combination, for the treatment of adults with newly diagnosed therapy-related ...
A. Krauss, Xin Gao, Liang Li, M. Manning, Paresma Patel, W. Fu, Kumar G. Janoria, G. Gieser, David A. Bateman, D. Przepiorka, Y. Shen, S. Shord, Christopher M. Sheth, A. Banerjee, Jiang Liu, Kirsten B. Goldberg, A. Farrell, G. Blumenthal, R. Pazdur   +18 more
semanticscholar   +1 more source

BL‐8040 CXCR4 antagonist is safe and demonstrates antileukemic activity in combination with cytarabine for the treatment of relapsed/refractory acute myelogenous leukemia: An open‐label safety and efficacy phase 2a study

Cancer, 2020
CXCR4 mediates the retention and survival of acute myelogenous leukemia blasts in bone marrow and contributes to their resistance to chemotherapy. The authors evaluated a combination of the high‐affinity CXCR4 antagonist BL‐8040 with high‐dose cytarabine
G. Borthakur, Y. Ofran, M. Tallman, J. Foran, G. Uy, J. Dipersio, M. Showel, A. Shimoni, A. Nagler, J. Rowe, J. Altman, Michal Abraham, A. Peled, Stephen M. Shaw, O. Bohana‐Kashtan, E. Sorani, Y. Pereg, A. Foley-Comer, G. Oberkovitz, Tzipi Lustig, Irit Glicko-Kabir, A. Aharon, A. Vainstein-Haras, S. Kadosh, E. Samara, Ahmed Al-rawi, N. Pemmaraju, C. Bueso-Ramos, J. Cortes, M. Andreeff   +29 more
semanticscholar   +1 more source

Primary CNS Lymphoma [PDF]

, 2014
Primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system is an aggressive malignancy that exhibits unique biological features and characteristic clinical behaviour, with overall long-term survival rates of around 20–40 %.
Cwynarski, K, Fox, CP, Phillips, EH
core   +1 more source

Mutant C/EBPα p30 alleviates immunosuppression of CD8+ T cells by inhibiting autophagy‐associated secretion of IL‐1β in AML

Cell Proliferation, Volume 55, Issue 12, December 2022., 2022
Mp30 suppresses autophagy‐associated IL‐β secretion, which ultimately alleviates the immunosuppression of CD8+ T cells in the microenvironment, contributing to favourable prognosis of AML patients. Abstract Objectives Mutant C/EBPα p30 (mp30), the product of C/EBPα double mutations (DM), lacks transactivation domain 1 and has C‐terminal loss‐of ...
Jun‐Dan Wang, Jue‐Qiong Xu, Xue‐Ning Zhang, Ze‐Wei Huang, Ling‐Ling Liu, Ling Zhang, Xin‐Xing Lei, Man‐Jie Xue, Jian‐Yu Weng, Zi‐Jie Long   +9 more
wiley   +1 more source

Pharmacokinetics of multivesicular liposomal encapsulated cytarabine when administered subcutaneously in dogs

Journal of Veterinary Internal Medicine, 2020
Background Prolonged cytotoxic concentrations of cytarabine (CA) are required for maximum cytotoxicity. DepoCyt is a human liposomal cytarabine (LC) product that lasts longer in plasma and CSF compared with free CA (FC).
Irene B. Vazquez Fuster, Amanda R. Taylor, Annette N. Smith, Sue H. Duran, William R. Ravis, Shanese L. Jasper, Robert D. Arnold   +6 more
doaj   +1 more source

Randomized Trial of Intermediate-dose Cytarabine in Induction and Consolidation Therapy in Adults with Acute Myeloid Leukemia

Clinical Cancer Research, 2020
Purpose: Cytarabine, 100–200 mg/mE+2/day, is commonly used in induction therapy of acute myelogenous leukemia (AML). Whether a higher dose of cytarabine would be more effective is unknown. Also, there is controversy whether high-dose cytarabine is better
Hui Wei, Ying Wang, R. Gale, D. Lin, Chun-lin Zhou, Bing-cheng Liu, S. Qiu, R. Gu, Yan Li, Xing-li Zhao, S. Wei, B. Gong, Kaiqi Liu, X. Gong, Yuntao Liu, Guangji Zhang, Z. Song, Yang Wang, Wei Li, Y. Mi, Jianxiang Wang   +20 more
semanticscholar   +1 more source

Sodium N-lauryl amino acids derived from silk protein can form catanionic aggregates with cytarabine as novel anti-tumor drug delivery systems

Drug Delivery, 2020
A sodium N-lauryl amino acids (shortly silk sericin surfactant, SSS) is synthesized with lauryl chloride and sericin amino acids recovered from silk industrial waste. The purpose of this study is to explore whether the sericin surfactant can be used as a
Meng Zhang, Shu-Xiang Zhao, Biao Ding, Yu-Qing Zhang   +3 more
doaj   +1 more source