Results 81 to 90 of about 1,936 (197)
Bioactivity-guided isolation of the cultures of the endophytic fugus Xylaria sp. XC-16 residing in a deciduous tree Toona sinensis led to the discovery of four new allelochemicals (1-4), including three cytochalasins, epoxycytochalasin Z 17 (1 ...
Han W. -B. +6 more
core +2 more sources
This study provides the first definitive identification of tunnelling nanotubes (TNTs) between cultured osteocytes and shows TNT‐mediated lysosome transfer from healthy to stressed cells, restoring autophagic flux and preventing apoptosis. This discovery of transcellular autophagy reveals a new survival mechanism in osteocytes, offering potential ...
Jinbiao Qiang +16 more
wiley +1 more source
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh +4 more
wiley +1 more source
Relative potencies of different cytochalasins for the inhibition of phagocytosis in ciliates
Ciliate actins have been reported to exhibit an unusual degree of sequence divergence, within the phylum Ciliophora, and when compared to actins from other organisms.
Zackroff, Robert V., Hufnagel, Linda A.
core +1 more source
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma +1 more
wiley +1 more source
The LAV‐BPIFB4‐Platelet‐CD47 Axis: A Novel Mechanism Associated With Immune Resilience in Longevity
Centenarians display elevated CD47+ reticulated platelets, a trait recapitulated in LAV‐BPIFB4 carriers on total platelet pool. LAV‐BPIFB4 drives an early acquirement of CD47 surface expression, enabling platelets to suppress monocyte IL‐6 release. rhLAV‐BPIFB4 phenocopies the effects in non‐genetic carriers, establishing the platelet–CD47–monocyte ...
Elena Ciaglia +13 more
wiley +1 more source
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez +10 more
wiley +1 more source
Cytochalasins from endophytic Diaporthe sp. GDG-118
The plant Sophora tonkinensis, possessed a range of active compounds, was traditionally used in the medicine of Chinese minorities. Endophytic fungi were isolated from this plant, of which the fungus Diaporthe sp. GDG-118 was fermented and extracted with
Tuxiang Mo (6918122) +9 more
core +1 more source
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto +14 more
wiley +1 more source
Cytochalasins from the endophytic fungus Phomopsis sp cib-109
A series of cytochalasins (1-6), including a new one (1), were isolated from the ethyl acetate extract of the solid-state fermented rice culture of the fungus Phomopsis sp. cib-109.
Zhan, Feng +5 more
core

