Results 121 to 130 of about 383,545 (307)

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Isolation and characterization of cytochrome b-562 from cytochrome b-c1 comlex of the photosynthetic bacterium Rhodopseudomonas sphaeroides R-26

, 1985
A b-type cytochrome (cytochrome b-562) was highly purified from the isolated cytochrome b-c1 complex of Rhodopseudomonas sphaeroides R-26 by treatment with sodium N-lauroyl sarcosinate (sarkosyi) and sodium thiocyanate, followed by gel filtration.
Iba, Koh, Ken-ichiro Takamiya, Hiroyuki Arata, Arata, Hiroyuki, Koh Iba, Takamiya, Ken-ichiro   +5 more
core   +1 more source

Understanding the Catalytic Determinant role of Diaphorase‐Like Subunit in Formate Dehydrogenases via Redox Couples

Advanced Science, EarlyView.
A unique mechanism of catalytic bias regulated by diaphorase‐like subunit in formate dehydrogenase from Rhodobacter aestuarii is revealed. The diaphorase‐like subunit functions act as a biological “voltage rheostat” that controls the slow release of NADH to regulate redox balance, biasing the enzyme's catalytic preference toward CO2 reduction over ...
Kuncheng Zhang, Weisong Liu, Hao Su, Huijuan Cui, Yuanming Wang, Zhiguang Zhu, Chun You, Lingling Zhang   +7 more
wiley   +1 more source

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Phylogenetic position of Mexican jackrabbits within the genus Lepus (Mammalia: Lagomorpha): a molecular perspective Posición filogenética de las liebres mexicanas dentro del género Lepus (Mammalia: Lagomorpha): una perspectiva molecular

Revista Mexicana de Biodiversidad, 2010
Although phylogenetic affinities of Mexican jackrabbits within the genus Lepus have been evaluated for a few species, no study has included all 5 species occurring in Mexico.
Juan Pablo Ramírez-Silva, Francisco Xavier González-Cózatl, Ella Vázquez-Domínguez, Fernando Alfredo Cervantes   +3 more
doaj  

Mitochondrial Genome-Encoded Long Noncoding RNA Cytochrome B and Mitochondrial Dysfunction in Diabetic Retinopathy. [PDF]

Antioxid Redox Signal, 2023
Mohammad G, Kumar J, Kowluru RA.
europepmc   +1 more source

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

Multiple Rieske Iron Sulfur Proteins of Photosynthesis in the Cyanobacterium Synechocystis SP PCC 6803

, 2012
A Thesis Submitted In Partial Fulfillment of the Requirements For the Degree of Master of Science-BiologyThe cytochrome bf complex is essential for both photosynthetic and respiratory electron transport in cyanobacteria.
Ranade, Saurabh J.
core  

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source