Results 181 to 190 of about 358,220 (258)

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie, EarlyView.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +2 more sources

Erste Hinweise auf Ozonido‐TMC‐Komplexe von Eisen und Kobalt

Angewandte Chemie, EarlyView.
Die Umsetzung der Eisen(II)‐Komplexe [(TMC)Fe(OTf)]BArF und [(D12‐TMC)Fe(OTf)]BArF sowie der Kobalt(II)‐Komplexe [(TMC)Co(OTf)]BArF und [(D12‐TMC)Co(X)]BArF (X = OTf, F) mit Ozon führt in einem 4:1‐Gemisch aus 2‐Me‐THF und THF bei Temperaturen bis −155°C zur Bildung von Ozonido‐ und Oxido‐Komplexen.
Stefan Schaub, Dennis Gerbig, Raffael C. Wende, Heike Hausmann, Jonathan Becker, Christian Würtele, Laura Senft, Ina Kellner, Gunasekaran Velmurugan, Marion Kerscher, Ivana Ivanović‐Burmazović, Peter Comba, Joshua Telser, Peter R. Schreiner, Siegfried Schindler   +14 more
wiley   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Sex-dependent adaptations in heart mitochondria from transgenic mice overexpressing cytochrome b₅ reductase-3. [PDF]

Mitochondrion
Sánchez-Mendoza LM, González-Reyes JA, Rodríguez-López S, Calvo-Rubio M, Calero-Rodríguez P, de Cabo R, Burón MI, Villalba JM.   +7 more
europepmc   +1 more source

Entdeckung eines antiviralen Elektronentransferprozesses zur Erzeugung katalytisch selbstversorgender viraler Restriktionsfaktoren

Angewandte Chemie, EarlyView.
CYB5R3 wird als mutmaßlicher Elektronentransferpartner von Viperin (RSAD2) identifiziert, was erklärt, warum die ER‐Lokalisation für die antivirale Aktivität erforderlich ist. Dieses Wissen ermöglichte die Entwicklung immunstiller, katalytisch selbstversorgender antiviraler Restriktionsfaktor‐Enzyme (iCAREs), die ein antivirales Nukleosidtriphosphat ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

Isosteric Engineering of Enzymes: Overcoming Activity–Stability Trade‐Offs by Site‐Selective CH → N Substitutions

Angewandte Chemie, EarlyView.
Coupling biosynthetic noncanonical amino acid production with genetic code expansion enables site‐specific incorporation of azatryptophans into PET‐degrading enzymes (PETases). By isosteric single‐atom editing of a conserved tryptophan, AzaPETases break the activity–stability trade‐off, delivering higher catalytic efficiency at elevated temperature and
Elwy H. Abdelkader, Haocheng Qianzhu, Gottfried Otting, Thomas Huber   +3 more
wiley   +2 more sources

Adult Leigh Syndrome Associated with the m.15635T>C Mitochondrial DNA Variant Affecting the Cytochrome <i>b</i> (<i>MT-CYB</i>) Gene. [PDF]

Int J Mol Sci
Tropeano CV, La Morgia C, Achilli A, Iommarini L, Tioli G, Caporali L, Olivieri A, Valentino ML, Liguori R, Barboni P, Martinuzzi A, Tonon C, Lodi R, Torroni A, Carelli V, Ghelli AM.   +15 more
europepmc   +1 more source

First Evidence for Ozonido‐TMC Complexes of Iron and Cobalt

Angewandte Chemie International Edition, EarlyView.
Reaction of ozone with iron(II) complexes [(TMC)Fe(OTf)]BArF, [(D12‐TMC)Fe(OTf)]BArF, and cobalt(II) complexes [(TMC)Co(OTf)]BArF, [(D12‐TMC)Co(X)]BArF (X = OTf, F) gives ozonido and oxido complexes at temperatures as low as –155°C in a 4:1 mixture of 2‐Me‐THF and THF. ABSTRACT We present compelling evidence for the first Fe‐ and Co‐ozonido complexes: [
Stefan Schaub, Dennis Gerbig, Raffael C. Wende, Heike Hausmann, Jonathan Becker, Christian Würtele, Laura Senft, Ina Kellner, Gunasekaran Velmurugan, Marion Kerscher, Ivana Ivanović‐Burmazović, Peter Comba, Joshua Telser, Peter R. Schreiner, Siegfried Schindler   +14 more
wiley   +1 more source

The cytochrome b carboxyl-terminal region is necessary for mitochondrial Complex III assembly

, 2022
Flores-Mireles D, Camacho-Villasana Y, Lutikurti M, García-Guerrero AE, Lozano-Rosas G, Chagoya V, Gutiérrez-Cirlos EB, Brandt U, Cabrera-Orefice A, Pérez-Martínez X.   +9 more
europepmc   +1 more source

Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self‐Sufficient Viral Restriction Factors

Angewandte Chemie International Edition, EarlyView.
CYB5R3 is identified as a putative electron‐transfer partner of viperin (RSAD2), explaining why ER localisation is required for antiviral activity. Its utilisation enabled the engineering of immune‐silent, catalytically self‐sufficient antiviral restriction factor enzymes (iCAREs) that produce an antiviral nucleoside triphosphate analogue (ANTA ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source