Results 181 to 190 of about 127,776 (263)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Organic and Inorganic Pollutants, Oxidative Stress Biomarkers, and Electrophoretic Protein Profiles in an Endangered Thresher Shark (Alopias vulpinus) From Southeastern Brazil: A Case Study

Environmental Toxicology, EarlyView.
ABSTRACT A comprehensive screening of different environmental contaminants (total metals, thermostable metal fractions associated with detoxification, and persistent organic pollutants) was conducted in an endangered common thresher shark (Alopias vulpinus ) individual incidentally captured in southeastern Brazil.
Sidney Fernandes Sales Junior, Amanda Pontes Lopes, Heloíse Martins de Souza, Regina Fonseca, Enrico Mendes Saggioro, Francielli Monteiro Casanova, Kamila Cezar Gramlich, Tatiana Dillenburg Saint'Pierre, Carlos German Massone, Renato Carreira, Rachel Ann Hauser‐Davis   +10 more
wiley   +1 more source

Genetic diversity and spatiotemporal population structure of Anopheles sinensis in the Republic of Korea based on the mitochondrial cytochrome c oxidase subunit I (COI) marker. [PDF]

Osong Public Health Res Perspect
Jung H, Han BG, Shin HI, Lee MR, Ju JW, Lee HI.   +5 more
europepmc   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

Integrative Genomic and in Silico Analysis Reveals Mitochondrially Encoded Cytochrome C Oxidase III (MT-CO3) Overexpression and Potential Neem-Derived Inhibitors in Breast Cancer. [PDF]

Genes (Basel)
Agboola OE, Agboola SS, Oyinloye OM, Fadugba AE, Omolayo EY, Ayinla ZA, Osunsanmi FO, Olaiya OE, Olojo FO, Ajiboye BO, Oyinloye BE.   +10 more
europepmc   +1 more source

Influence of Age and Exposure Pathway on Copper and Cadmium Mixture Toxicity: A Study on Daphnia magna

Environmental Toxicology, EarlyView.
ABSTRACT Metal contamination in aquatic ecosystems poses substantial risks to freshwater organisms, with mixture effects often deviating from predictions based on single‐metal toxicity. Understanding how age‐specific sensitivities and multiple exposure pathways influence mixture effects is critical for accurate risk assessment.
Sanah Majid, Karen Smeets, Mubiana K. Valentine, Ronny Blust   +3 more
wiley   +1 more source

Mitochondrial markers (<i>cytochrome c oxidase subunit I</i> and <i>16S ribosomal RNA</i>) as supporting biomarkers for wild bird identification. [PDF]

Vet World
Marín-Villa J, López-Herrera A, Gómez-Ruiz DA, Restrepo-Rodas DC, Sánchez-Rodríguez G, Úsuga-Monroy C.   +5 more
europepmc   +1 more source

Climate‐Modulated Particle Toxicity: Acute Exposure to an Environmentally Informed Microplastic Mixture Induces Sex‐Dependent Systemic Reorganization in Swiss Mice

Environmental Toxicology, EarlyView.
ABSTRACT Microplastic (MP) pollution is widely recognized as an emerging environmental threat. Yet, most studies still rely on controlled experimental conditions that poorly reflect environmental complexity, potentially underestimating risks under realistic scenarios, particularly during short‐term exposures. Here, we tested whether acute oral exposure
Guilherme Malafaia, Rafaela Ribeiro de Brito, Aline Sueli de Lima de Rodrigues, Omar Cruz Santiago, Andrés Hugo Arias, Thiarlen Marinho da Luz   +5 more
wiley   +1 more source

Investigation of the Protective Effect of Morin on Oxidative Stress and Apoptosis in Malathion‐Induced Hepatotoxicity in Rats

Environmental Toxicology, EarlyView.
ABSTRACT Malathion (MAL) is a widely used organophosphate pesticide associated with hepatotoxicity through oxidative stress and apoptosis. Morin, a naturally occurring flavonoid, exhibits potent antioxidant and anti‐inflammatory properties. This study investigated oxidative stress, inflammatory, and apoptotic alterations induced by acute and subacute ...
Seval Yılmaz, Eda İ. Demirbağ, Hakan Bağ, Ali O. Çeribaşı   +3 more
wiley   +1 more source