Results 1 to 10 of about 140,758 (163)

NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain [PDF]

Cell Metabolism, 2012
The oxidative phosphorylation system is one of the best-characterized metabolic pathways. In mammals, the protein components and X-ray structures are defined for all complexes except complex I. Here, we show that NDUFA4, formerly considered a constituent of NADH Dehydrogenase (CI), is instead a component of the cytochrome c oxidase (CIV).
Enrique Calvo, JOSÉ Antonio Enriquez, Radek Szklarczyk   +2 more
exaly   +5 more sources

Glutathionylated and Fe–S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain

Redox Biology, 2020
Human MIA40, an intermembrane space (IMS) import receptor of mitochondria harbors twin CX9C motifs for stability while its CPC motif is known to facilitate the import of IMS bound proteins.
Venkata Ramana Thiriveedi, Ushodaya Mattam, Prasad Pattabhi, Vandana Bisoyi, Noble Kumar Talari, Thanuja Krishnamoorthy, Naresh Babu V. Sepuri   +6 more
doaj   +4 more sources

Mitochondrial Function and Parkinson’s Disease: From the Perspective of the Electron Transport Chain

Frontiers in Molecular Neuroscience, 2021
Parkinson’s disease (PD) is known as a mitochondrial disease. Some even regarded it specifically as a disorder of the complex I of the electron transport chain (ETC).
Jeng-Lin Li, Jeng-Lin Li, Tai-Yi Lin, Po-Lin Chen, Ting-Ni Guo, Shu-Yi Huang, Chun-Hong Chen, Chin-Hsien Lin, Chin-Hsien Lin, Chih-Chiang Chan   +9 more
doaj   +2 more sources

Inhibitory Effect of ATP on Cytochrome c Oxidase Depends on Electron Entry Pathways by TCA Cycle Metabolites [PDF]

Cells
The ATP-dependent inhibition of cytochrome c oxidase (CytOx, complex IV of the electron transport chain) is the second mechanism of respiratory control adjusting mitochondrial respiration in order to prevent excessive electron flow and reactive oxygen ...
Madeline Günther, Valeria Pakic, Petra Weber, Anke Veit, Carsten Culmsee, Ardawan J. Rastan, Annegret P. Busch, Sebastian Vogt   +7 more
doaj   +2 more sources

Complex I preserves mitochondrial polarization during infection of human macrophages by secretion-competent bacteria [PDF]

Infection and Immunity
Intracellular bacteria remodel host bioenergetics and modulate mitochondrial membrane potential (Δψm). However, how individual electron transport chain (ETC) components sustain Δψm during infection of primary human macrophages remains unclear.
Francisco-Javier Garcia-Rodriguez, Paula Martinez-Oca, Carmen Buchrieser, Pedro Escoll   +3 more
doaj   +2 more sources

Impact of mitochondrial reductive stress due to respiratory chain limitation on cancer via posttranslational modifications [PDF]

Redox Biology
Respiratory chain limitation is a recurrent but spatially heterogeneous state in solid tumors, driven by hypoxic subregions, electron transport chain defects, and signaling- or therapy-imposed respiratory inhibition.
Christos Chinopoulos
doaj   +2 more sources

Direct dapagliflozin exposure enhances respiration and membrane hyperpolarization in isolated cardiac mitochondria [PDF]

Frontiers in Physiology
Dapagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor widely used for the treatment of diabetes, has been consistently associated with cardiovascular protection, including attenuation of ischemia/reperfusion injury and reduced incidence of ...
Itanna Isis Araújo de Souza, César Francisco Maricato da Rosa, Laís Eduardo Marinho, Marcella Borges Coutinho, Caroline Da Silva Moraes, Antonio Carlos Campos de Carvalho, José Hamilton Matheus Nascimento, Leonardo Maciel de Oliveira Pinto, Leonardo Maciel de Oliveira Pinto, Leonardo Maciel de Oliveira Pinto   +9 more
doaj   +2 more sources

APOE expression and secretion are modulated by mitochondrial dysfunction

eLife, 2023
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors.
Meghan E Wynne, Oluwaseun Ogunbona, Alicia R Lane, Avanti Gokhale, Stephanie A Zlatic, Chongchong Xu, Zhexing Wen, Duc M Duong, Sruti Rayaprolu, Anna Ivanova, Eric A Ortlund, Eric B Dammer, Nicholas T Seyfried, Blaine R Roberts, Amanda Crocker, Vinit Shanbhag, Michael Petris, Nanami Senoo, Selvaraju Kandasamy, Steven Michael Claypool, Antoni Barrientos, Aliza Wingo, Thomas S Wingo, Srikant Rangaraju, Allan I Levey, Erica Werner, Victor Faundez   +26 more
doaj   +1 more source

New insight into the mechanism of mitochondrial cytochrome c function. [PDF]

PLoS ONE, 2017
We investigate functional role of the P76GTKMIFA83 fragment of the primary structure of cytochrome c. Based on the data obtained by the analysis of informational structure (ANIS), we propose a model of functioning of cytochrome c. According to this model,
Rita V Chertkova, Nadezda A Brazhe, Tatiana V Bryantseva, Alexey N Nekrasov, Dmitry A Dolgikh, Alexander I Yusipovich, Olga Sosnovtseva, Georgy V Maksimov, Andrei B Rubin, Mikhail P Kirpichnikov   +9 more
doaj   +1 more source

ETMB-RBF: discrimination of metal-binding sites in electron transporters based on RBF networks with PSSM profiles and significant amino acid pairs. [PDF]

PLoS ONE, 2013
BACKGROUND: Cellular respiration is the process by which cells obtain energy from glucose and is a very important biological process in living cell. As cells do cellular respiration, they need a pathway to store and transport electrons, the electron ...
Yu-Yen Ou, Shu-An Chen, Sheng-Cheng Wu
doaj   +1 more source