Results 1 to 10 of about 102,377 (268)

Glutathionylated and Fe–S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain

Redox Biology, 2020
Human MIA40, an intermembrane space (IMS) import receptor of mitochondria harbors twin CX9C motifs for stability while its CPC motif is known to facilitate the import of IMS bound proteins.
Venkata Ramana Thiriveedi, Ushodaya Mattam, Prasad Pattabhi, Vandana Bisoyi, Noble Kumar Talari, Thanuja Krishnamoorthy, Naresh Babu V. Sepuri   +6 more
doaj   +5 more sources

Evaluation of functioning of mitochondrial electron transport chain with NADH and FAD autofluorescence [PDF]

The Ukrainian Biochemical Journal, 2016
We prove the feasibility of evaluation of mitochondrial electron transport chain function in isolated mitochondria of smooth muscle cells of rats from uterus using fluorescence of NADH and FAD coenzymes. We found the inversely directed changes in FAD and
H. V. Danylovych
doaj   +2 more sources

Mitochondrial Function and Parkinson’s Disease: From the Perspective of the Electron Transport Chain

Frontiers in Molecular Neuroscience, 2021
Parkinson’s disease (PD) is known as a mitochondrial disease. Some even regarded it specifically as a disorder of the complex I of the electron transport chain (ETC).
Jeng-Lin Li, Jeng-Lin Li, Tai-Yi Lin, Po-Lin Chen, Ting-Ni Guo, Shu-Yi Huang, Chun-Hong Chen, Chin-Hsien Lin, Chin-Hsien Lin, Chih-Chiang Chan   +9 more
doaj   +2 more sources

Age-related deficiencies in complex I endogenous substrate availability and reserve capacity of complex IV in cortical neuron electron transport

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Respiratory enzyme complex dysfunction is mechanistically involved in mitochondrial failure leading to neurodegenerative disease, but the pathway is unclear. Here, age-related differences in mitochondrial respiration were measured in both whole and permeabilized neurons from 9-month and 24-month adult rat cortex cultured in common conditions.
Jones, Torrie T., Brewer, Gregory J.
openaire   +3 more sources

Inhibitory Effect of ATP on Cytochrome c Oxidase Depends on Electron Entry Pathways by TCA Cycle Metabolites [PDF]

Cells
The ATP-dependent inhibition of cytochrome c oxidase (CytOx, complex IV of the electron transport chain) is the second mechanism of respiratory control adjusting mitochondrial respiration in order to prevent excessive electron flow and reactive oxygen ...
Madeline Günther, Valeria Pakic, Petra Weber, Anke Veit, Carsten Culmsee, Ardawan J. Rastan, Annegret P. Busch, Sebastian Vogt   +7 more
doaj   +2 more sources

Advanced modeling of bioenergetics in the mitochondrial electron transport chain with emphasis on complex IV

Alzheimer's & Dementia
AbstractBackgroundMitochondrial bioenergetics are essential for cellular function, specifically the intricacies of the electron transport chain (ETC), with Complex IV playing a crucial role in unraveling the mechanisms governing energy production. Mathematical models offer a valuable approach to simulate these complex processes, providing insights into
Keleshteri, Marzieh Eini, Cadonic, Chris D, Ghafourian, Taravat, Thomson, Ella, Snow, Wanda M, McAllister, Danielle, Djordjevic, Jelena, Chowdhury, Subir K Roy, Fernyhough, Paul, Fiege, Jason D, Portet, Stephanie D, Albensi, Benedict C   +11 more
openaire   +2 more sources

Endurance exercise training in pulmonary hypertension increases skeletal muscle electron transport chain supercomplex assembly

Pulmonary Circulation, 2020
Pulmonary hypertension is associated with pronounced exercise intolerance (decreased V ċ O 2 max) that can significantly impact quality of life. The cause of exercise intolerance in pulmonary hypertension remains unclear. Mitochondrial supercomplexes are
Danielle J. McCullough, Nouaying Kue, Thomas Mancini, Alexander Vang, Richard T. Clements, Gaurav Choudhary   +5 more
doaj   +2 more sources

Complex I preserves mitochondrial polarization during infection of human macrophages by secretion-competent bacteria [PDF]

Infection and Immunity
Intracellular bacteria remodel host bioenergetics and modulate mitochondrial membrane potential (Δψm). However, how individual electron transport chain (ETC) components sustain Δψm during infection of primary human macrophages remains unclear.
Francisco-Javier Garcia-Rodriguez, Paula Martinez-Oca, Carmen Buchrieser, Pedro Escoll   +3 more
doaj   +2 more sources

Impact of mitochondrial reductive stress due to respiratory chain limitation on cancer via posttranslational modifications [PDF]

Redox Biology
Respiratory chain limitation is a recurrent but spatially heterogeneous state in solid tumors, driven by hypoxic subregions, electron transport chain defects, and signaling- or therapy-imposed respiratory inhibition.
Christos Chinopoulos
doaj   +2 more sources

Direct dapagliflozin exposure enhances respiration and membrane hyperpolarization in isolated cardiac mitochondria [PDF]

Frontiers in Physiology
Dapagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor widely used for the treatment of diabetes, has been consistently associated with cardiovascular protection, including attenuation of ischemia/reperfusion injury and reduced incidence of ...
Itanna Isis Araújo de Souza, César Francisco Maricato da Rosa, Laís Eduardo Marinho, Marcella Borges Coutinho, Caroline Da Silva Moraes, Antonio Carlos Campos de Carvalho, José Hamilton Matheus Nascimento, Leonardo Maciel de Oliveira Pinto, Leonardo Maciel de Oliveira Pinto, Leonardo Maciel de Oliveira Pinto   +9 more
doaj   +2 more sources