Results 31 to 40 of about 420,770 (265)

COA6 facilitates cytochrome c oxidase biogenesis as thiol-reductase for copper metallochaperones in mitochondria.

, 2020
The mitochondrial cytochrome c oxidase, the terminal enzyme of the respiratory chain, contains heme and copper centers for electron transfer. The conserved COX2 subunit contains the CuA site, a binuclear copper center.
Aich, A., Bogeski, I., Chacinska, A., Chudenkova, M., Deckers, M., Dennerlein, S., Gibhardt, C., Oeljeklaus, S., Pacheu-Grau, D., Rehling, P., Warscheid, B., Wasilewski, M.   +11 more
core   +2 more sources

Anesthesia-Sepsis-Associated Alterations in Liver Gene Expression Profiles and Mitochondrial Oxidative Phosphorylation Complexes

Frontiers in Medicine, 2020
Background: Hepatic dysfunction plays a major role in adverse outcomes in sepsis. Volatile anesthetic agents may protect against organ dysfunction in the setting of critical illness and infection.
Hari Prasad Osuru, Umadevi Paila, Keita Ikeda, Zhiyi Zuo, Robert H. Thiele   +4 more
doaj   +1 more source

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice [PDF]

, 2014
Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles.
Jové, Mariona, Naudí, Alba, Pamplona, Reinald, Portero-Otín, Manuel, Ramírez-Núñez, Omar, Selman, Colin, Withers, Dominic J.   +6 more
core   +3 more sources

Hyperoxia decreases glycolytic capacity, glycolytic reserve and oxidative phosphorylation in MLE-12 cells and inhibits complex I and II function, but not complex IV in isolated mouse lung mitochondria.

PLoS ONE, 2013
High levels of oxygen (hyperoxia) are frequently used in critical care units and in conditions of respiratory insufficiencies in adults, as well as in infants.
Kumuda C Das
doaj   +1 more source

Electrophysiological and molecular mechanisms of protection by iron sucrose against phosphine-induced cardiotoxicity: A time course study [PDF]

, 2015
The present study was designed for determining the exact mechanism of cytotoxic action of aluminum phosphide (AlP) in the presence of iron sucrose as the proposed antidote.
Abdollahi, M., Baeeri, M., Baghaei, A., Golaghaei, A., Hasani, S., Hosseini, R., Navaei, M., Ostad, S.N., Solgi, R.   +8 more
core   +1 more source

High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal

Molecular Neurodegeneration, 2011
Background The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC 1.10.2.2) and complex IV (cytochrome c oxidase EC 1.9.3.1) are reduced by 30-70% in Huntington's disease and Alzheimer's disease, respectively, and are ...
Kilbride Seán M, Gluchowska Sonia A, Telford Jayne E, O'Sullivan Catherine, Davey Gavin P   +4 more
doaj   +1 more source

Differential requirements for mitochondrial electron transport chain components in the adult murine liver

eLife, 2022
Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans and displays striking tissue specificity depending on the affected gene.
Nicholas P Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron J Menezes, Sara House, Spencer D Shelton, Andrew Lemoff, David G McFadden, Janaka Wansapura, Ralph J DeBerardinis, Prashant Mishra   +11 more
doaj   +1 more source

Linear, third- and fifth-order nonlinear spectroscopy of a charge transfer system coupled to an underdamped vibration [PDF]

, 2015
We study hole, electron and exciton transport in a charge transfer system in the presence of underdamped vibrational motion. We analyze the signature of these processes in the linear and third-, and fifth-order nonlinear electronic spectra.
Dijkstra, Arend G., Tanimura, Yoshitaka
core   +2 more sources

The outer membrane protein Omp35 affects the reduction of Fe(III), nitrate, and fumarate by Shewanella oneidensis MR-1

BMC Microbiology, 2004
Background Shewanella oneidensis MR-1 uses several electron acceptors to support anaerobic respiration including insoluble species such as iron(III) and manganese(IV) oxides, and soluble species such as nitrate, fumarate, dimethylsulfoxide and many ...
Myers Charles R, Maier Tamara M
doaj   +1 more source

6-PPD quinone at environmentally relevant concentrations activates feedback response of electron transport chain to mediate damage on mitochondrial function and longevity in Caenorhabditis elegans

Environmental Chemistry and Ecotoxicology
6-PPD quinone (6-PPDQ) could cause mitochondrial dysfunction; however, response of entire electron transport chain to 6-PPDQ remains largely unclear. In Caenorhabditis elegans, activity of mitochondrial complex IV was inhibited by 6-PPDQ (1–10 μg/L), and
Xin Hua, Dayong Wang
doaj   +1 more source