Results 11 to 20 of about 140,758 (163)
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010 Respiratory enzyme complex dysfunction is mechanistically involved in mitochondrial failure leading to neurodegenerative disease, but the pathway is unclear. Here, age-related differences in mitochondrial respiration were measured in both whole and permeabilized neurons from 9-month and 24-month adult rat cortex cultured in common conditions.
Jones, Torrie T., Brewer, Gregory J.
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Electron Transport Chain Complex II Regulates Steroid Metabolism
iScience, 2020 Summary: The first steroidogenic enzyme, cytochrome P450-side-chain-cleavage (SCC), requires electron transport chain (ETC) complexes III and IV to initiate steroid metabolic processes for mammalian survival.
Himangshu S. Bose +4 more
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PLoS ONE, 2013 High levels of oxygen (hyperoxia) are frequently used in critical care units and in conditions of respiratory insufficiencies in adults, as well as in infants.
Kumuda C Das
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The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. [PDF]
PLoS ONE, 2014 Intralipid® administration at reperfusion elicits protection against myocardial ischemia-reperfusion injury. However, the underlying mechanisms are not fully understood.Sprague-Dawley rat hearts were exposed to 15 min of ischemia and 30 min of ...
Phing-How Lou +11 more
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PLoS ONE, 2013 Mitochondrial electron transport chain (ETC) defects are observed in Parkinson's disease (PD) patients and in PD fly- and mouse-models; however it remains to be tested if acute improvement of ETC function alleviates PD-relevant defects.
Melissa Vos +9 more
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Ascorbate Biosynthesis in Mitochondria Is Linked to the Electron Transport Chain between Complexes III and IV [PDF]
Plant Physiology, 2000 Abstract Ascorbic acid is synthesized from galactono-γ-lactone (GL) in plant tissues. An improved extraction procedure involving ammonium sulfate precipitation of membrane proteins from crude leaf homogenates yielded a simple, quick method for determining tissue activities of galactono-γ-lactone dehydrogenase (GLDH).
Bartoli, Carlos Guillermo +2 more
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Evaluation of functioning of mitochondrial electron transport chain with NADH and FAD autofluorescence [PDF]
The Ukrainian Biochemical Journal, 2016 We prove the feasibility of evaluation of mitochondrial electron transport chain function in isolated mitochondria of smooth muscle cells of rats from uterus using fluorescence of NADH and FAD coenzymes. We found the inversely directed changes in FAD and
H. V. Danylovych
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PLoS Pathogens, 2023 The mitochondrial electron transport chain (ETC) of apicomplexan parasites differs considerably from the ETC of the animals that these parasites infect, and is the target of numerous anti-parasitic drugs.
Rachel A Leonard +4 more
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Proceedings of the National Academy of Sciences of the United States of America, 2021 In mammalian cells, cyanide is viewed as a cytotoxic agent, which exerts its effects through inhibition of mitochondrial Complex IV (Cytochrome C oxidase [CCOx]).
Elisa B. Randi +4 more
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PLoS ONE, 2021 BackgroundPyridoxine-dependent epilepsy (PDE) is due to biallelic variants in ALDH7A1 (PDE-ALDH7A1). ALDH7A1 encodes α-aminoadipic semialdehyde dehydrogenase in lysine catabolism.
Anastasia Minenkova +7 more
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