Results 21 to 30 of about 420,770 (265)

Age-related deficiencies in complex I endogenous substrate availability and reserve capacity of complex IV in cortical neuron electron transport

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Respiratory enzyme complex dysfunction is mechanistically involved in mitochondrial failure leading to neurodegenerative disease, but the pathway is unclear. Here, age-related differences in mitochondrial respiration were measured in both whole and permeabilized neurons from 9-month and 24-month adult rat cortex cultured in common conditions.
Jones, Torrie T., Brewer, Gregory J.
openaire   +2 more sources

Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

eLife, 2021
While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue ...
Sina C Rosenkranz, Artem A Shaposhnykov, Simone Träger, Jan Broder Engler, Maarten E Witte, Vanessa Roth, Vanessa Vieira, Nanne Paauw, Simone Bauer, Celina Schwencke-Westphal, Charlotte Schubert, Lukas Can Bal, Benjamin Schattling, Ole Pless, Jack van Horssen, Marc Freichel, Manuel A Friese   +16 more
doaj   +1 more source

Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors

eLife, 2022
Mammalian carotid body arterial chemoreceptors function as an early warning system for hypoxia, triggering acute life-saving arousal and cardiorespiratory reflexes. To serve this role, carotid body glomus cells are highly sensitive to decreases in oxygen
Alba Timón-Gómez, Alexandra L Scharr, Nicholas Y Wong, Erwin Ni, Arijit Roy, Min Liu, Julisia Chau, Jack L Lampert, Homza Hireed, Noah S Kim, Masood Jan, Alexander R Gupta, Ryan W Day, James M Gardner, Richard JA Wilson, Antoni Barrientos, Andy J Chang   +16 more
doaj   +1 more source

Structural studies of T4S systems by electron microscopy [PDF]

, 2015
: Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNA and/or proteins through the membranes of bacteria. Analysis of T4S system architecture is an extremely challenging task taking into account their multi protein ...
Abdallah AM, Gey van Pittius NC, Champion PA, et a, Backert S, Meyer TF, Bailey S, Ward D, Middleton R, et al., Banta LM, Kerr JE, Cascales E, et al., Cascales E, Cascales E, Christie PJ, Cascales E, Christie PJ, Christie PJ, Atmakuri K, Krishnamoorthy V, et al., Christie PJ, Cascales E, Clemens DL, Ge P, Lee BY, et al., Cornelis GR, Van Gijsegem F, De Carlo S, Harris JR, de Jong MF, Sun YH, den Hartigh AB, et al., Dubochet J, Durand E, Waksman G, Receveur-Brechot V, Eisenbrandt R, Kalkum M, Lai EM, et al., Filloux A, Fronzes R, Christie PJ, Waksman G, Fronzes R, Schafer E, Wang L, et al., Gomis-Ruth FX, Moncalian G, Perez-Luque R, et al., Henderson IR, Navarro-Garcia F, Desvaux M, et al., Hofreuter D, Karnholz A, Haas R, Jakubowski SJ, Kerr JE, Garza I, et al., Jakubowski SJ, Krishnamoorthy V, Cascales E, et al, Judd PK, Mahli D, Das A, Kerr JE, Christie PJ, Kudryashev M, Wang RY, Brackmann M, et al., Lederberg J, Tatum EL, Lessl M, Lanka E, Li X, Mooney P, Zheng S, et al., Llosa M, de la Cruz F, Low HH, Gubellini F, Rivera-Calzada A, et al., McMullan G, Faruqi AR, Henderson R, et al., Mossey P, Hudacek A, Das A, Ninio S, Roy CR, Orlova EV, Saibil HR, Pansegrau W, Lanka E, Pena A, Matilla I, Martin-Benito J, et al., Ripoll-Rozada J, Zunzunegui S, de la Cruz F, et al, Rivera-Calzada A, Fronzes R, Savva CG, et al., Savvides SN, Yeo HJ, Beck MR, et al., Schraidt O, Marlovits TC, Schroder G, Krause S, Zechner EL, et al., Sivanesan D, Baron C, Terradot L, Bayliss R, Oomen C, et al., Trokter M, Felisberto-Rodrigues C, Christie PJ, et, Wallden K, Williams R, Yan J, et al., Yeo HJ, Savvides SN, Herr AB, et al., Yeo HJ, Yuan Q, Beck MR, et al., Yuan Q, Carle A, Gao C, et al., Zechner EL, Lang S, Schildbach JF   +50 more
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Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle. [PDF]

, 2017
Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and ...
Amati, F., Auwerx, J., Boutant, M., Broskey, N.T., Cantó, C., Conde Alonso, S., Greggio, C., Jha, P., Kulkarni, S.S., Lagarrigue, S., Ofori, E., Wang, X.   +11 more
core   +1 more source

Potentially Diagnostic Electron Paramagnetic Resonance Spectra Elucidate the Underlying Mechanism of Mitochondrial Dysfunction in the Deoxyguanosine Kinase Deficient Rat Model of a Genetic Mitochondrial DNA Depletion Syndrome [PDF]

, 2016
A novel rat model for a well-characterized human mitochondrial disease, mitochondrial DNA depletion syndrome with associated deoxyguanosine kinase (DGUOK) deficiency, is described.
Bennett, Brian, Dimmock, David P., Friederich, Marisa W., Geurts, Aron M., Helbling, Daniel, Jarzembowski, Jason, Lawlor, Michael W., Meng, Hui, Van Hove, Johan L.K.   +8 more
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Glutathione binding to the plant AtAtm3 transporter and implications for the conformational coupling of ABC transporters

eLife, 2022
The ATP binding cassette (ABC) transporter of mitochondria (Atm) from Arabidopsis thaliana (AtAtm3) has been implicated in the maturation of cytosolic iron-sulfur proteins and heavy metal detoxification, plausibly by exporting glutathione derivatives ...
Chengcheng Fan, Douglas C Rees
doaj   +1 more source

Sordaria macrospora Sterile Mutant pro34 Is Impaired in Respiratory Complex I Assembly

Journal of Fungi, 2022
The formation of fruiting bodies is a highly regulated process that requires the coordinated formation of different cell types. By analyzing developmental mutants, many developmental factors have already been identified.
Andrea Hamann, Heinz D. Osiewacz, Ines Teichert   +2 more
doaj   +1 more source

Brownian dynamics simulation of cytochrome c diffusion and binding with cytochrome c1 in mitochondrial crista [PDF]

ITM Web of Conferences, 2020
Cytochrome c (Cc) protein shuttles electrons from respiratory chain complex III — from cytochrome c1 (Cc1) subunit — to complex IV during oxidative phosphorylation, in intermembrane space of mitochondria and cristae lumen.
Abaturova Anna M., Brazhe Nadezda A., Kovalenko Ilya B., Riznichenko Galina Yu, Rubin Andrei B.   +4 more
doaj   +1 more source

The ‘porin-cytochrome’ model for microbe-to-mineral electron transfer [PDF]

, 2012
Many species of bacteria can couple anaerobic growth to the respiratory reduction of insoluble minerals containing Fe(III) or Mn(III/IV). It has been suggested that in Shewanella species electrons cross the outer membrane to extracellular substrates via ‘
Afkar, Baron, Bouhenni, Burns, Cao, Clarke, Clarke, Clarke, Coursolle, DiChristina, Dohnalkova, Donald, Eggleston, El-Naggar, Firer-Sherwood, Firer-Sherwood, Gorby, Gralnick, Hartshorne, Hartshorne, Heidelberg, Jensen, Jiang, Jiao, Johs, Kerisit, Leang, Lies, Liu, Lower, Lower, Lower, Malvankar, Malvankar, Marsili, McLean, Meitl, Myers, Peretyazhko, Pessanha, Qian, Reardon, Reguera, Reguera, Roessler, Ross, Schuetz, Shi, Shi, Smith, Strycharz-Glaven, Strycharz-Glaven, Taylor, von Canstein, Xiong, Zargar, Zhang, Zhang   +57 more
core   +2 more sources