Results 41 to 50 of about 140,758 (163)

6-PPD quinone at environmentally relevant concentrations activates feedback response of electron transport chain to mediate damage on mitochondrial function and longevity in Caenorhabditis elegans

Environmental Chemistry and Ecotoxicology
6-PPD quinone (6-PPDQ) could cause mitochondrial dysfunction; however, response of entire electron transport chain to 6-PPDQ remains largely unclear. In Caenorhabditis elegans, activity of mitochondrial complex IV was inhibited by 6-PPDQ (1–10 μg/L), and
Xin Hua, Dayong Wang
doaj   +1 more source

Differential requirements for mitochondrial electron transport chain components in the adult murine liver

eLife, 2022
Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans and displays striking tissue specificity depending on the affected gene.
Nicholas P Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron J Menezes, Sara House, Spencer D Shelton, Andrew Lemoff, David G McFadden, Janaka Wansapura, Ralph J DeBerardinis, Prashant Mishra   +11 more
doaj   +1 more source

The outer membrane protein Omp35 affects the reduction of Fe(III), nitrate, and fumarate by Shewanella oneidensis MR-1

BMC Microbiology, 2004
Background Shewanella oneidensis MR-1 uses several electron acceptors to support anaerobic respiration including insoluble species such as iron(III) and manganese(IV) oxides, and soluble species such as nitrate, fumarate, dimethylsulfoxide and many ...
Myers Charles R, Maier Tamara M
doaj   +1 more source

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

Proceedings of the National Academy of Sciences of the United States of America, 2019
Down syndrome (DS) is associated with significant perturbances in mitochondrial function. Here we tested the hypothesis that the suppression of mitochondrial electron transport in DS cells is due to high expression of cystathionine-β-synthase (CBS) and ...
T. Panagaki, Elisa B. Randi, Fiona Augsburger, C. Szabó   +3 more
semanticscholar   +1 more source

Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue

Scientific Reports, 2022
Advances in multiplex immunofluorescence (mIF) and digital image analysis has enabled simultaneous assessment of protein defects in electron transport chain components. However, current manual methodology is time consuming and labour intensive. Therefore,
Ashwin Sachdeva, Claire A. Hart, Christopher D. Carey, Amy E. Vincent, Laura C. Greaves, Rakesh Heer, Pedro Oliveira, Michael D. Brown, Noel W. Clarke, Doug M. Turnbull   +9 more
doaj   +1 more source

Mitochondrial Complex IV Remodeling in Tumor-Associated Macrophages Amplifies Interferon Signaling and Promotes Anti-Tumor Immunity

Immunity
Summary Tumor-associated macrophages (TAMs) influence tumor progression and immune checkpoint blockade (ICB) efficacy. Interferon (IFN)-TAMs predict better survival and ICB responses, yet the mechanisms governing IFN-TAM programming remain unclear. Here,
M. Clark, K. Simeonov, Walter K. Mowel, Michaël F. Michieletto, Leonel Joannas, Jasmine M Wright, Isabel Erickson, Lexus Johnson, Rakesh Krishnan, César de la Fuente-Núñez, Andy J. Minn, J. Henao-Mejía   +11 more
semanticscholar   +1 more source

Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

International Journal of Molecular Medicine, 2019
The mammalian mitochondrial electron transport chain (ETC) includes complexes I-IV, as well as the electron transporters ubiquinone and cytochrome c. There are two electron transport pathways in the ETC: Complex I/III/IV, with NADH as the substrate and ...
Ruzhou Zhao, Shuai Jiang, Lin Zhang, Zhi-Bin Yu   +3 more
semanticscholar   +1 more source

Efficient Electron Hopping Transport through Azurin-Based Junctions

Journal of Physical Chemistry Letters, 2023
We conducted a theoretical study of electron transport through junctions of the blue-copper azurin from Pseudomonas aeruginosa. We found that single-site hopping can lead to either higher or lower current values compared to fully coherent transport. This
C. Roldán-Piñero, C. Romero-Muñiz, Ismael Díez-Pérez, J. Vilhena, R. Pérez, Juan Carlos Cuevas, L. Zotti   +6 more
semanticscholar   +1 more source

Improved Functionality of Poly(3,4-Ethylenedioxythiophene):Poly(Styrenesulfonate)/HeptaCoordinated Organotin Complex Films via Graphene Applied to Organic Solar Cell Fabrications

Frontiers in Materials, 2022
Enhanced transparency, conductivity, and stability are some of the most important factors to consider in order to prepare transparent electrodes (TEs) and hole transport layer (HTL) for organic solar cells.
María Elena Sánchez Vergara, Rafael Imanol Zubillaga Serrano, Leon Hamui, José Miguel Galván Hidalgo, Ismael Cosme, Elizabeth Gómez   +5 more
doaj   +1 more source

SQR mediates therapeutic effects of H2S by targeting mitochondrial electron transport to induce mitochondrial uncoupling

Science Advances, 2020
A sulfide oxidase mediates therapeutic actions of H2S by targeting mitochondrial electron flow to induce mitochondrial uncoupling. Hydrogen sulfide (H2S) is a gasotransmitter and a potential therapeutic agent.
J. Jia, Zichuang Wang, Minjie Zhang, Caiyun Huang, Yanmei Song, Fuyou Xu, Jingyu Zhang, J. Li, Meijun He, Yuyao Li, Guizhen Ao, Chengjiao Hong, Yongjun Cao, Y. Chin, Z. Hua, Jian Cheng   +15 more
semanticscholar   +1 more source