Results 41 to 50 of about 420,770 (265)

Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue

open access: yesScientific Reports, 2022
Advances in multiplex immunofluorescence (mIF) and digital image analysis has enabled simultaneous assessment of protein defects in electron transport chain components. However, current manual methodology is time consuming and labour intensive. Therefore,
Ashwin Sachdeva   +9 more
doaj   +1 more source

The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. [PDF]

open access: yesPLoS ONE, 2014
Intralipid® administration at reperfusion elicits protection against myocardial ischemia-reperfusion injury. However, the underlying mechanisms are not fully understood.Sprague-Dawley rat hearts were exposed to 15 min of ischemia and 30 min of ...
Phing-How Lou   +11 more
doaj   +1 more source

Improved Functionality of Poly(3,4-Ethylenedioxythiophene):Poly(Styrenesulfonate)/HeptaCoordinated Organotin Complex Films via Graphene Applied to Organic Solar Cell Fabrications

open access: yesFrontiers in Materials, 2022
Enhanced transparency, conductivity, and stability are some of the most important factors to consider in order to prepare transparent electrodes (TEs) and hole transport layer (HTL) for organic solar cells.
María Elena Sánchez Vergara   +5 more
doaj   +1 more source

Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells

open access: yesFrontiers in Cell and Developmental Biology, 2021
Mitochondria are double-membrane organelles that contain their own genome, the mitochondrial DNA (mtDNA), and reminiscent of its endosymbiotic origin.
Stefan Geldon   +2 more
doaj   +1 more source

Mechanisms of Bacterial Extracellular Electron Exchange. [PDF]

open access: yes, 2016
The biochemical mechanisms by which microbes interact with extracellular soluble metal ions and insoluble redox-active minerals have been the focus of intense research over the last three decades. The process presents two challenges to the microorganism;
Butt, Julea N.   +5 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Low mass binary neutron star mergers : gravitational waves and neutrino emission [PDF]

open access: yes, 2016
Neutron star mergers are among the most promising sources of gravitational waves for advanced ground-based detectors. These mergers are also expected to power bright electromagnetic signals, in the form of short gamma-ray bursts, infrared/optical ...
Duez, Matthew D.   +9 more
core   +3 more sources

Impaired exercise performance and skeletal muscle mitochondrial function in rats with secondary carnitine deficiency

open access: yesFrontiers in Physiology, 2016
Purpose: The effects of carnitine depletion upon exercise performance and skeletal muscle mitochondrial function remain largely unexplored. We therefore investigated the effect of N-trimethyl-hydrazine-3-propionate (THP), a carnitine analogue inhibiting ...
Jamal BOUITBIR   +6 more
doaj   +1 more source

Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miRNA-210 and protein synthesis inhibition. [PDF]

open access: yesPLoS ONE, 2013
Fetal growth is critically dependent on energy metabolism in the placenta, which drives active exchange of nutrients. Placental oxygen levels are therefore vital, and chronic hypoxia during pregnancy impairs fetal growth.
Francesca Colleoni   +7 more
doaj   +1 more source

Home - About - Disclaimer - Privacy