Results 51 to 60 of about 140,758 (163)

Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells

Frontiers in Cell and Developmental Biology, 2021
Mitochondria are double-membrane organelles that contain their own genome, the mitochondrial DNA (mtDNA), and reminiscent of its endosymbiotic origin.
Stefan Geldon, Erika Fernández-Vizarra, Kostas Tokatlidis   +2 more
doaj   +1 more source

Decreased mitochondrial electron transport proteins and increased complement mediators in plasma neural-derived exosomes of early psychosis

Translational Psychiatry, 2020
Potentially neurotoxic systems involved in traumatic and degenerative diseases of the brain were assessed in acute psychosis. Astrocyte-derived exosomes (ADEs) and neuron-derived exosomes (NDEs) were immunoprecipitated from plasma of ten untreated first ...
E. Goetzl, V. Srihari, S. Guloksuz, M. Ferrara, C. Tek, G. Heninger   +5 more
semanticscholar   +1 more source

Impaired exercise performance and skeletal muscle mitochondrial function in rats with secondary carnitine deficiency

Frontiers in Physiology, 2016
Purpose: The effects of carnitine depletion upon exercise performance and skeletal muscle mitochondrial function remain largely unexplored. We therefore investigated the effect of N-trimethyl-hydrazine-3-propionate (THP), a carnitine analogue inhibiting ...
Jamal BOUITBIR, Patrizia HAEGLER, François SINGH, Lorenz JOERIN, Andrea FELSER, Urs DUTHALER, Stephan KRAEHENBUEHL   +6 more
doaj   +1 more source

Advanced modeling of bioenergetics in the mitochondrial electron transport chain with emphasis on complex IV

Alzheimer's & Dementia
AbstractBackgroundMitochondrial bioenergetics are essential for cellular function, specifically the intricacies of the electron transport chain (ETC), with Complex IV playing a crucial role in unraveling the mechanisms governing energy production. Mathematical models offer a valuable approach to simulate these complex processes, providing insights into
Keleshteri, Marzieh Eini, Cadonic, Chris D, Ghafourian, Taravat, Thomson, Ella, Snow, Wanda M, McAllister, Danielle, Djordjevic, Jelena, Chowdhury, Subir K Roy, Fernyhough, Paul, Fiege, Jason D, Portet, Stephanie D, Albensi, Benedict C   +11 more
openaire   +1 more source

Unlocking potential: the role of the electron transport chain in immunometabolism.

Trends in immunology
The electron transport chain (ETC) couples electron transfer with proton pumping to generate ATP and it also regulates particular innate and adaptive immune cell function.
Alessia Zotta, L. O'Neill, Maureen Yin
semanticscholar   +1 more source

Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miRNA-210 and protein synthesis inhibition. [PDF]

PLoS ONE, 2013
Fetal growth is critically dependent on energy metabolism in the placenta, which drives active exchange of nutrients. Placental oxygen levels are therefore vital, and chronic hypoxia during pregnancy impairs fetal growth.
Francesca Colleoni, Nisha Padmanabhan, Hong-Wa Yung, Erica D Watson, Irene Cetin, Martha C Tissot van Patot, Graham J Burton, Andrew J Murray   +7 more
doaj   +1 more source

Emerging risk from "environmentally-friendly" solvents: interaction of methylimidazolium ionic liquids with the mitochondrial electron transport chain is a key initiation event in their mammalian toxicity.

Food and Chemical Toxicology, 2020
Recent studies have identified the 8C alkyl chain methylimidazolium ionic liquid 1-octyl-3-methylimidazolium in the environment and its potential to trigger the auto-immune liver disease primary biliary cholangitis.
Tarek M. Abdelghany, Alistair C Leitch, Irena Nevjestić, I. Ibrahim, S. Miwa, Colin Wilson, S. Heutz, M. Wright   +7 more
semanticscholar   +1 more source

Astragaloside IV Inhibits Mitochondrial-Dependent Apoptosis of the Dorsal Root Ganglion in Diabetic Peripheral Neuropathy Rats Through Modulation of the SIRT1/p53 Signaling Pathway

Diabetes, Metabolic Syndrome and Obesity, 2021
Ying Ben,1,2,* Juan Hao,1,* Zhihong Zhang,1,2 Yunzhao Xiong,1 Cuijuan Zhang,1,2 Yi Chang,1,2 Fan Yang,1,2 Hui Li,1,2 Tianya Zhang,1 Xiangting Wang,1,2 Qingyou Xu1,2 1Hebei University of Chinese Medicine, Shijiazhuang, Hebei, People’s Republic of ...
Ben Y, Hao J, Zhang Z, Xiong Y, Zhang C, Chang Y, Yang F, Li H, Zhang T, Wang X, Xu Q   +10 more
doaj  

Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency

eLife, 2023
Malonyl-CoA-acyl carrier protein transacylase (MCAT) is an enzyme involved in mitochondrial fatty acid synthesis (mtFAS) and catalyzes the transfer of the malonyl moiety of malonyl-CoA to the mitochondrial acyl carrier protein (ACP).
Bryn D Webb, Sara M Nowinski, Ashley Solmonson, Jaya Ganesh, Richard J Rodenburg, Joao Leandro, Anthony Evans, Hieu S Vu, Thomas P Naidich, Bruce D Gelb, Ralph J DeBerardinis, Jared Rutter, Sander M Houten   +12 more
doaj   +1 more source

Streptozotocin-Induced Adaptive Modification of Mitochondrial Supercomplexes in Liver of Wistar Rats and the Protective Effect of Moringa oleifera Lam

Biochemistry Research International, 2018
The increasing prevalence of diabetes continues to be a major health issue worldwide. Alteration of mitochondrial electron transport chain is a recognized hallmark of the diabetic-associated decline in liver bioenergetics; however, the molecular events ...
María Alejandra Sánchez-Muñoz, Mónica Andrea Valdez-Solana, Mara Ibeth Campos-Almazán, Óscar Flores-Herrera, Mercedes Esparza-Perusquía, Sofia Olvera-Sánchez, Guadalupe García-Arenas, Claudia Avitia-Domínguez, Alfredo Téllez-Valencia, Erick Sierra-Campos   +9 more
doaj   +1 more source