Results 61 to 70 of about 140,758 (163)

Organization of the Respiratory Supercomplexes in Cells with Defective Complex III: Structural Features and Metabolic Consequences

Life, 2021
The mitochondrial respiratory chain encompasses four oligomeric enzymatic complexes (complex I, II, III and IV) which, together with the redox carrier ubiquinone and cytochrome c, catalyze electron transport coupled to proton extrusion from the inner ...
Michela Rugolo, Claudia Zanna, Anna Maria Ghelli   +2 more
doaj   +1 more source

Mitochondrial Electron Transport Chain Protein Abnormalities Detected in Plasma Extracellular Vesicles in Alzheimer’s Disease

Biomedicines, 2021
Mitochondria provide energy to neurons through oxidative phosphorylation and eliminate Reactive Oxygen Species (ROS) through Superoxide Dismutase 1 (SOD1).
Pamela J. Yao, Erden Eren, Edward J. Goetzl, Dimitrios Kapogiannis   +3 more
doaj   +1 more source

Structural study of Topoisomerase IV-DNA-Levofloxacin complexes from Streptococcus pneumoniae [PDF]

E3S Web of Conferences, 2019
S. pneumoniae is an important pathogen causing pulmonary infection, acute otitis media and purulent meningitis in infants and children. Type II topoisomerases are enzymes that play essential roles in DNA replication, chromosome segregation and ...
Wang Xilan
doaj   +1 more source

Sodium fluoride causes oxidative damage to silkworm (Bombyx mori) testis by affecting the oxidative phosphorylation pathway

Ecotoxicology and Environmental Safety, 2021
Bombyx mori was used to study the molecular mechanism of fluoride induced reproductive toxicity. In our previous study, we confirmed the physiological and biochemical effects of NaF on reproductive toxicity, and we found that the molecular mechanism of ...
Wenchao Tang, Yuanyuan Xiao, Yaohang Long, Yaofeng Li, Fang Peng, Can Zhu, Tinggui He, Didong Lou, Yong Zhu   +8 more
doaj   +1 more source

Euglena’s atypical respiratory chain adapts to the discoidal cristae and flexible metabolism

Nature Communications
Euglena gracilis, a model organism of the eukaryotic supergroup Discoba harbouring also clinically important parasitic species, possesses diverse metabolic strategies and an atypical electron transport chain.
Zhaoxiang He, Mengchen Wu, Hongtao Tian, Liangdong Wang, Yiqi Hu, Fangzhu Han, Jiancang Zhou, Yong Wang, Long Zhou   +8 more
doaj   +1 more source

Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPRMT and increased resistance to oxidative stress in primary cultures of fibroblasts

Redox Biology, 2016
Mice deficient in the electron transport chain (ETC) complex IV assembly protein SURF1 have reduced assembly and activity of cytochrome c oxidase that is associated with an upregulation of components of the mitochondrial unfolded protein response (UPRMT)
Gavin A. Pharaoh, Daniel A. Pulliam, Shauna Hill, Kavithalakshmi Sataranatarajan, H. Van Remmen   +4 more
semanticscholar   +1 more source

Enhanced Skeletal Muscle Oxidative Capacity and Capillary-to-Fiber Ratio Following Moderately Increased Testosterone Exposure in Young Healthy Women

Frontiers in Physiology, 2020
Background: Recently, it was shown that exogenously administered testosterone enhances endurance capacity in women. In this study, our understanding on the effects of exogenous testosterone on key determinants of oxygen transport and utilization in ...
Daniele A. Cardinale, Daniele A. Cardinale, Oscar Horwath, Jona Elings-Knutsson, Jona Elings-Knutsson, Torbjörn Helge, Manne Godhe, Stéphane Bermon, Marcus Moberg, Mikael Flockhart, Filip J. Larsen, Angelica Lindén Hirschberg, Angelica Lindén Hirschberg, Björn Ekblom   +13 more
doaj   +1 more source

Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson’s disease

Scientific Reports, 2019
Multiple system atrophy (MSA) is a neurodegenerative disease characterised by glial cytoplasmic inclusions (GCIs), containing α-synuclein. Mutated COQ2, encoding an enzyme essential for co-enzyme Q10 (CoQ10) biosynthesis, has been associated with MSA ...
S. Foti, I. Hargreaves, Stephanie Carrington, A. Kiely, H. Houlden, J. Holton   +5 more
semanticscholar   +1 more source

Unique, Diverged, and Conserved Mitochondrial Functions Influencing Candida albicans Respiration

mBio, 2019
Candida albicans is an opportunistic fungal pathogen of major clinical concern. The virulence of this pathogen is intimately intertwined with its metabolism.
Nuo Sun, Rebecca S. Parrish, Richard A. Calderone, William A. Fonzi   +3 more
doaj   +1 more source

Characterization of Mutations in the Mitochondrial Encoded Electron Transport Chain Complexes in Acute Myeloid Leukemia

Scientific Reports, 2018
Acute Myeloid Leukemia is a devastating and heterogeneous, hematological malignancy characterized by the uncontrolled proliferation of undifferentiated myeloid progenitor cells—blasts.
Sharon K. Wu, M. Akhtari, Houda Alachkar
semanticscholar   +1 more source