Results 61 to 70 of about 10,822,815 (272)

Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model.

PLoS ONE, 2013
Mitochondrial electron transport chain (ETC) defects are observed in Parkinson's disease (PD) patients and in PD fly- and mouse-models; however it remains to be tested if acute improvement of ETC function alleviates PD-relevant defects.
Melissa Vos, Blaise Lovisa, Ann Geens, Vanessa A Morais, Georges Wagnières, Hubert van den Bergh, Alec Ginggen, Bart De Strooper, Yanik Tardy, Patrik Verstreken   +9 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Interaction networks of modulated genes included in the electron transport chain in cows vaccinated prior to calving.

, 2015
A: Downregulated genes included in the electron transport chain in cows vaccinated prior to calving (BC). Red: upregulated loci, green: downregulated loci. B: Interaction networks for loci in complex I in BC cows using IPA network analysis.
Frieder Hadlich (732945), Wiebke Demasius (790105), Rosemarie Weikard (82446), Christa Kühn (790106)   +3 more
core   +1 more source

Electron Temperature Gradient Mode Transport [PDF]

, 2008
Anomalous electron thermal losses plays a central role in the history of the controlled fusion program being the first and most persistent form of anomalous transport across all toroidal magnetic confinement devices. In the past decade the fusion program
Kaye, S. M., Horton, W., H. Park, LeBlanc, B. P., G. T. Hoang, Hoang, G. T., B. P. LeBlanc, Kim, J. H., J.-H. Kim, S. M. Kaye, W. Horton, Sadruddin Benkadda, Park, H.   +12 more
core   +1 more source

Streptozotocin-Induced Adaptive Modification of Mitochondrial Supercomplexes in Liver of Wistar Rats and the Protective Effect of Moringa oleifera Lam

Biochemistry Research International, 2018
The increasing prevalence of diabetes continues to be a major health issue worldwide. Alteration of mitochondrial electron transport chain is a recognized hallmark of the diabetic-associated decline in liver bioenergetics; however, the molecular events ...
María Alejandra Sánchez-Muñoz, Mónica Andrea Valdez-Solana, Mara Ibeth Campos-Almazán, Óscar Flores-Herrera, Mercedes Esparza-Perusquía, Sofia Olvera-Sánchez, Guadalupe García-Arenas, Claudia Avitia-Domínguez, Alfredo Téllez-Valencia, Erick Sierra-Campos   +9 more
doaj   +1 more source

Organization of the Respiratory Supercomplexes in Cells with Defective Complex III: Structural Features and Metabolic Consequences

Life, 2021
The mitochondrial respiratory chain encompasses four oligomeric enzymatic complexes (complex I, II, III and IV) which, together with the redox carrier ubiquinone and cytochrome c, catalyze electron transport coupled to proton extrusion from the inner ...
Michela Rugolo, Claudia Zanna, Anna Maria Ghelli   +2 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Inhibitory Effect of ATP on Cytochrome c Oxidase Depends on Electron Entry Pathways by TCA Cycle Metabolites

Cells
The ATP-dependent inhibition of cytochrome c oxidase (CytOx, complex IV of the electron transport chain) is the second mechanism of respiratory control adjusting mitochondrial respiration in order to prevent excessive electron flow and reactive oxygen ...
Madeline Günther, Valeria Pakic, Petra Weber, Anke Veit, Carsten Culmsee, Ardawan J. Rastan, Annegret P. Busch, Sebastian Vogt   +7 more
doaj   +1 more source

Mitochondrial Electron Transport Chain Protein Abnormalities Detected in Plasma Extracellular Vesicles in Alzheimer’s Disease

Biomedicines, 2021
Mitochondria provide energy to neurons through oxidative phosphorylation and eliminate Reactive Oxygen Species (ROS) through Superoxide Dismutase 1 (SOD1).
Pamela J. Yao, Erden Eren, Edward J. Goetzl, Dimitrios Kapogiannis   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source