Results 121 to 130 of about 9,195 (133)

Pharmacogenetics Approach for Personalized Tacrolimus Dosing in Heart Transplantation: A Case Report and Literature Review. [PDF]

Genes (Basel)
Nikpalj N, Samardžić J, Božina N, Šimičević L, Ganoci L, Božina T.   +5 more
europepmc   +1 more source

Flavonoids and Furanocoumarins Involved in Drug Interactions. [PDF]

Molecules
Berteina-Raboin S.
europepmc   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter-Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™). [PDF]

Clin Pharmacol Ther
Chothe PP, Whitcher-Johnstone A, Karve A, Ramsden D, Hariparsad N.   +4 more
europepmc   +1 more source

Drug-Drug Interaction Liabilities with BTK Inhibitor TL-895. [PDF]

Cancer Res Commun
Stromatt JC, Ahmed EA, Drabison T, Nepal MR, Chowdhury AT, Orwick SJ, Buelow DR, Eisenmann ED, Huang KM, Sparreboom A, Baker SD.   +10 more
europepmc   +1 more source

Transcription factors of the Nuclear Factor I (NFI) family control hepatocyte differentiation and cytochrome P450 activity in human liver.

Pharmacol Res
Klein K, Burk O, Tremmel R, Buettner FA, Kaestle L, Schroth W, Muerdter TE, Eccles D, Schmidt AC, Nieß H, Zanger UM, Schwab M, Lauschke VM.   +12 more
europepmc   +1 more source

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Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1)

Biochimica et Biophysica Acta (BBA) - General Subjects, 1994
A cDNA encoding a novel member of the cytochrome P-450 superfamily, Cyp3a-13, has been isolated from mouse liver cDNA library by hybridization screening. The Cyp3a-13 encoded 503 amino acid residues and shared 71% amino acid identity with Cyp3a-11.
T, Yanagimoto, S, Itoh, M, Sawada, H, Hashimoto, T, Kamataki   +4 more
openaire   +2 more sources

Insulin Differentially Affects Xenobiotic-Enhanced, Cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A Expression in Primary Cultured Rat Hepatocytes

The Journal of Pharmacology and Experimental Therapeutics, 1999
Uncontrolled diabetes results in enhanced expression of cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A. Because of the simultaneous and confounding metabolic and hormonal changes that occur in vivo as a consequence of diabetes, primary cultured rat hepatocytes provide an excellent model system for examination of the effects of insulin on P-450 ...
K J, Woodcroft, R F, Novak
openaire   +2 more sources

Particular ability of cytochrome P-450 CYP3A to reduce glyceryl trinitrate in rat liver microsomes: Subsequent formation of nitric oxide

Chemico-Biological Interactions, 1993
Glyceryl trinitrate was denitrated in rat hepatic subcellular fractions, with formation of glyceryl dinitrates and glyceryl mononitrates. Among differently treated-rat liver microsomes, the highest microsomal activity was obtained under anaerobic conditions with microsomal preparations from dexamethasone-treated rats and NADPH.
Delaforge, Marcel, Servent, Denis, Wirsta, Philippe, Ducrocq, Claire, Mansuy, Daniel, Lenfant, Maryse   +5 more
openaire   +3 more sources

N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors.

The Journal of Pharmacology and Experimental Therapeutics, 1995
Biotransformation of amitriptyline (AMI) to its demethylated product nortriptyline (NT) was studied in vitro with human liver microsomes from four different donors, preselected to reflect a range of metabolic rates. Reaction velocity versus substrate concentration was consistent with a sigmoid Vmax model.
J, Schmider, D J, Greenblatt, L L, von Moltke, J S, Harmatz, R I, Shader   +4 more
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Inhibition of Cytochrome P-450 3A (CYP3A) in Human Intestinal and Liver Microsomes: Comparison of Ki Values and Impact of CYP3A5 Expression

Drug Metabolism and Disposition, 1999
The purpose of this study was to compare the kinetics of intestinal and hepatic cytochrome P-450 3A (CYP3A) inhibition by using microsomal midazolam 1'-hydroxylation as a marker of enzyme activity. The effect of two antifungal agents commonly implicated in CYP3A drug-drug interactions was examined.
M A, Gibbs, K E, Thummel, D D, Shen, K L, Kunze   +3 more
openaire   +2 more sources