Results 131 to 133 of about 9,195 (133)

The Glucocorticoid Receptor Is Essential for Induction of Cytochrome P-4502B by Steroids but Not for Drug or Steroid Induction of CYP3A or P-450 Reductase in Mouse Liver

Drug Metabolism and Disposition, 2000
Cytochrome P-4503A, CYP2B, and P-450 reductase are induced by glucocorticoids, antiglucocorticoids such as pregnenolone 16alpha-carbonitrile, and drugs such as rifampin and phenobarbital. Although the pregnane X receptor is reported to mediate steroid and drug activation of CYP3A via a conserved cis-element in CYP3A genes, discrepancies exist between ...
E G, Schuetz, W, Schmid, G, Schutz, C, Brimer, K, Yasuda, T, Kamataki, L, Bornheim, K, Myles, T J, Cole   +8 more
openaire   +2 more sources

[Clinical significance of some genetic polymorphisms of cytochrome P-450 subfamilies CYP2D, CYP2E and CYP3A--part II].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2010
Polymorphism of drugs biotransformation is clinically significant from the point of view of the effectiveness and safety of pharmacotherapy and an increased risk of some illnesses. The paper presents molecular mechanisms and clinical implication of several genetic polymorphisms of cytochrome P-450 (CYP) xenobiotics metabolizing enzymes and genetic ...
Anna, Wojtczak, Jadwiga, Skretkowicz
openaire   +1 more source

Role of cytochrome P-450 from the human CYP3A gene family in the potentiation of morpholino doxorubicin by human liver microsomes.

Cancer research, 1992
The cytotoxicity of the morpholino derivative of doxorubicin (MRA) can be potentiated 50- to 100-fold by human liver microsomes and NADPH (J. Natl. Cancer Inst., 81: 1034, 1989). This metabolic potentiation is inhibited by carbon monoxide or hypoxia, indicating that it is cytochrome P-450-dependent.
A D, Lewis, D H, Lau, G E, Durán, C R, Wolf, B I, Sikic   +4 more
openaire   +1 more source