Results 101 to 110 of about 102,281 (237)

The nitrite anion: the key intermediate in alkyl nitrates degradative mechanism. [PDF]

, 2007
Alkyl nitrates, _in vivo_, are metabolized to yield nitric oxide, and thiol groups are considered necessary cofactors. This statement is based on studies that underline how these species potentiate hemodynamic responsiveness to nitrates in patients with ...
Loris Grossi
core   +1 more source

Transcriptional Regulation of the Novel Theacrine Synthase Gene CsTcS2 by the CsTINY–CsWRKY33 Module Underpins Theacrine Biosynthesis in Camellia sinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Theacrine (1,3,7,9‐tetramethyluric acid) is a purine alkaloid detected in multiple wild and specialised tea germplasms (Camellia sinensis) from South China, including Kucha. However, the molecular mechanisms governing its biosynthesis remain poorly understood. Here, we identify CsTcS2 as a novel theacrine synthase in tea plant.
Ting Wu, Lihua Zhu, Chenyu Shao, Siyi Xie, Na Li, Xinyu Li, Fang Wang, Lvwen Peng, Huiying Jin, Fanghuizi Shang, Jianan Huang, Zhonghua Liu, Na Tian, Shuoqian Liu   +13 more
wiley   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Photodynamic priming (PDP) targets platinum resistance from chronic perfluoroalkyl substances (PFAS) exposure in ovarian cancer cells

Photochemistry and Photobiology, EarlyView.
PFAS are environmental contaminants that induce chemoresistance in ovarian cancer cells. This study evaluated BPD‐PDP or ALA‐PpIX‐PDP in combination with carboplatin or doxorubicin to overcome PFAS‐induced chemoresistance in two cell cohorts: (i) PFAS chronically‐exposed and (ii) PFAS outgrown cells (which underwent a “recovery period” after chronic ...
Brittany P. Rickard, Meghan M. Dillon, Lauren A. Sapienza‐Lundie, Suzanne E. Fenton, Imran Rizvi   +4 more
wiley   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Metabolic stimulation improves bioenergetics and haematologic indices of circulating erythrocytes from sickle cell mice

The Journal of Physiology, EarlyView.
Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida, Meghann L. Smith, Sayuri Kamimura, Sebastian Vogel, Zenaide M. N. Quezado   +4 more
wiley   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Mitochondrial physiology in cardiac muscle of deer mice native to high altitude

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem, Samuel G. Robichaud, Simon G. Lamarre, Graham R. Scott   +3 more
wiley   +1 more source

Evaluation of Salt‐Tolerant Guar (Cyamopsis tetragonoloba L.) Genotypes Based on Physiological, Biochemical, and Yield‐Related Traits

Legume Science, Volume 8, Issue 2, June 2026.
ABSTRACT The 15 guar genotypes were exposed to different concentrations of salt (0, 10, and 15 dS m−1 NaCl) in a factorial experiment (RCBD, r = 3) and different morpho‐physiological, physiological, growth, and yield characteristics were assessed. The lowest seed gum (21.11%), carbohydrate (23.59%), protein content (24.20%), fat (2.21%), fiber (9.38%),
WarqaaMuhammed ShariffAl‐Sheikh, Sahar A. A. Malik Al‐Saadi, Karzan Omer Qader, Heidar Meftahizade   +3 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source