Results 231 to 240 of about 127,252 (263)
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Cytochrome P450s and chemoprevention
Biochemical Society Transactions, 2000The cytochrome P450 mono-oxygenase system represents a major defence against chemical challenge from the environment, constituting part of an adaptive response mounted by an organism following exposure to harmful agents. Cytochrome P450s are also able to catalyse the activation of compounds to toxic products, and participate in a variety of essential ...
Henderson, C J, Sahraouei, A, Wolf, C R
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Archives of Biochemistry and Biophysics, 1997
Tolbutamide methyl hydroxylation and S-warfarin 7-hydroxylation activities were reconstituted in systems containing recombinant human cytochrome P450 (P450 or CYP) 2C10(2C9) and the optimal conditions for the systems were compared with those of bufuralol 1'-hydroxylation by CYP1A1, theophylline 8-hydroxylation by CYP1A2, bufuralol 1'-hydroxylation by ...
Yamazaki, H +5 more
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Tolbutamide methyl hydroxylation and S-warfarin 7-hydroxylation activities were reconstituted in systems containing recombinant human cytochrome P450 (P450 or CYP) 2C10(2C9) and the optimal conditions for the systems were compared with those of bufuralol 1'-hydroxylation by CYP1A1, theophylline 8-hydroxylation by CYP1A2, bufuralol 1'-hydroxylation by ...
Yamazaki, H +5 more
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Phytochemistry, 1994
The present status of plant cytochrome P450 research is reviewed. A comparison of the properties of this group of cytochrome proteins with those of other microsomal b-type haem proteins is made. The range of reactions catalysed by P450s is discussed as well as recent progress in improving purification and reconstitution.
G P Bolwell, Alfred Zimmerlin, K Bozak
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The present status of plant cytochrome P450 research is reviewed. A comparison of the properties of this group of cytochrome proteins with those of other microsomal b-type haem proteins is made. The range of reactions catalysed by P450s is discussed as well as recent progress in improving purification and reconstitution.
G P Bolwell, Alfred Zimmerlin, K Bozak
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Current Opinion in Structural Biology, 1995
Since 1993, three new cytochrome P450 X-ray structures have been determined, giving a total of four known structures. Two of the new structures are in the substrate-free form and one is substrate-bound. These new structures, together with a wealth of mutagenesis studies on various P450s, have provided considerable information on what structural ...
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Since 1993, three new cytochrome P450 X-ray structures have been determined, giving a total of four known structures. Two of the new structures are in the substrate-free form and one is substrate-bound. These new structures, together with a wealth of mutagenesis studies on various P450s, have provided considerable information on what structural ...
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Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1998
Since the last review of this topic, further insight has been gained into the presence and functions of cytochrome P450 proteins in the hepatopancreas and other organs of aquatic crustacean species, although progress has been slow relative to the advances in other species.
Margaret O. James, Sean M. Boyle
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Since the last review of this topic, further insight has been gained into the presence and functions of cytochrome P450 proteins in the hepatopancreas and other organs of aquatic crustacean species, although progress has been slow relative to the advances in other species.
Margaret O. James, Sean M. Boyle
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Drug Metabolism Reviews, 2004
The cytochrome P450 class of enzymes is an extremely important and complex group. It has a significant place in ADME (adsorption, distribution, metabolism, elimination) that those developing new dr...
Rajeshwar P. Verma +3 more
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The cytochrome P450 class of enzymes is an extremely important and complex group. It has a significant place in ADME (adsorption, distribution, metabolism, elimination) that those developing new dr...
Rajeshwar P. Verma +3 more
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Current Protocols in Pharmacology, 2001
AbstractCytochrome P450s (CYPs) play a major role in drug detoxification, and inhibition of CYP‐mediated metabolism may lead to accumulation of toxic drug levels in the plasma. To prevent adverse drug‐drug interactions, new drug candidates are routinely tested for their ability to inhibit these enzymes.
Enock Delaporte, A. David Rodrigues
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AbstractCytochrome P450s (CYPs) play a major role in drug detoxification, and inhibition of CYP‐mediated metabolism may lead to accumulation of toxic drug levels in the plasma. To prevent adverse drug‐drug interactions, new drug candidates are routinely tested for their ability to inhibit these enzymes.
Enock Delaporte, A. David Rodrigues
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