Results 261 to 270 of about 506,903 (380)

Endotoxin depresses hepatic cytochrome P450‐mediated drug metabolism in women [PDF]

, 1997
Steven I. Shedlofsky, B. C. Israel, Raina Tosheva, Robert A. Blouin   +3 more
openalex   +1 more source

Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fruquintinib (FRUZAQLATM) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3). Two Phase 1, open‐label, single‐dose studies investigated the impact of hepatic or renal impairment on the pharmacokinetics and tolerability of fruquintinib.
Martha Gonzalez, Zhao Yang, William Schelman, Thomas C. Marbury, Juan C. Rondon, William Smith, Xiaofei Zhou, Neeraj Gupta, Caly Chien   +8 more
wiley   +1 more source

Maintenance of oestradiol production and expression of cytochrome P450 aromatase enzyme mRNA in long-term serum-free cultures of pig granulosa cells [PDF]

, 1999
Helen M. Picton, B. K. Campbell, M. G. Hunter   +2 more
openalex   +1 more source

Clinical Evaluation of Drug–Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P‐gp Pathways

The Journal of Clinical Pharmacology, EarlyView.
Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora, Hui Liu, John Ling, Jason T. Hindman, Dhananjay D. Marathe   +4 more
wiley   +1 more source

Molecular Basis for Peptide Nitration by a Novel Cytochrome P450 Enzyme in RiPP Biosynthesis. [PDF]

ACS Catal
Nolan K, Usai R, Li B, Jordan S, Wang Y.
europepmc   +1 more source

Nitric Oxide Mediates Hepatic Cytochrome P450 Dysfunction Induced by Endotoxin [PDF]

, 1996
Claudia Müller, Annette Scierka, Richard L. Stiller, Yong-Myeong Kim, Ryan D. Cook, Jack R. Lancaster, Charles W. Buffington, David Watkins   +7 more
openalex   +1 more source

Establishing a Quantitative Framework for Combined Oral Contraceptives: Evaluating the Impact of Drug–Drug Interactions on Exposure and Clinical (Surrogate) Efficacy Endpoints

The Journal of Clinical Pharmacology, EarlyView.
Abstract According to the FDA Guidance for Industry on Clinical Drug Interaction (DDI) Studies with Combined Oral Contraceptives (COCs), sponsors are expected to conduct dedicated clinical DDI studies if in vitro findings suggest weak or moderate CYP3A induction, while concomitant use of COCs with strong inducers should be avoided. The guidance further
Dain Chun, Huili Chen, Brian Cicali, Serge Guzy, Joachim Hoechel, Tianze Jiao, Valvanera Vozmediano, Stephan Schmidt   +7 more
wiley   +1 more source

Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis. [PDF]

, 1996
C Beyeler, Melissa J. Armstrong, H. A. Bird, Jeffrey R. Idle, Ann K. Daly   +4 more
openalex   +1 more source

The Molecular Perspective: Cytochrome P450 [PDF]

Stem Cells, 2001
openaire   +4 more sources

Association of Polymorphisms of Cytochrome P450 2D6 With Blood Hydroxychloroquine Levels in Patients With Systemic Lupus Erythematosus

Arthritis & Rheumatology, 2015
J. Y. Lee, Nadimuthu Vinayagamoorthy, K. Han, S. Kwok, J. Ju, Kyung-Su Park, Seung-Hyun Jung, Sung‐Won Park, Y. Chung, Sung-Hwan Park   +9 more
semanticscholar   +1 more source