Results 301 to 310 of about 308,115 (327)
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Current Protocols in Pharmacology, 2001
AbstractCytochrome P450s (CYPs) play a major role in drug detoxification, and inhibition of CYP‐mediated metabolism may lead to accumulation of toxic drug levels in the plasma. To prevent adverse drug‐drug interactions, new drug candidates are routinely tested for their ability to inhibit these enzymes.
Enock, Delaporte, A David, Rodrigues
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AbstractCytochrome P450s (CYPs) play a major role in drug detoxification, and inhibition of CYP‐mediated metabolism may lead to accumulation of toxic drug levels in the plasma. To prevent adverse drug‐drug interactions, new drug candidates are routinely tested for their ability to inhibit these enzymes.
Enock, Delaporte, A David, Rodrigues
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SAR and QSAR in Environmental Research, 2001
This paper describes a specialized database dedicated exclusively to the cytochrome P450 superfamily. The system provides the impression of superfamily's nomenclature and describes structure and function of different P450 enzymes. Information on P450-catalyzed reactions, substrate preferences, peculiarities of induction and inhibition is available ...
A V, Lisitsa +4 more
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This paper describes a specialized database dedicated exclusively to the cytochrome P450 superfamily. The system provides the impression of superfamily's nomenclature and describes structure and function of different P450 enzymes. Information on P450-catalyzed reactions, substrate preferences, peculiarities of induction and inhibition is available ...
A V, Lisitsa +4 more
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Current Opinion in Structural Biology, 1995
Since 1993, three new cytochrome P450 X-ray structures have been determined, giving a total of four known structures. Two of the new structures are in the substrate-free form and one is substrate-bound. These new structures, together with a wealth of mutagenesis studies on various P450s, have provided considerable information on what structural ...
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Since 1993, three new cytochrome P450 X-ray structures have been determined, giving a total of four known structures. Two of the new structures are in the substrate-free form and one is substrate-bound. These new structures, together with a wealth of mutagenesis studies on various P450s, have provided considerable information on what structural ...
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Cytochrome P450s and chemoprevention
Biochemical Society Transactions, 2000The cytochrome P450 mono-oxygenase system represents a major defence against chemical challenge from the environment, constituting part of an adaptive response mounted by an organism following exposure to harmful agents. Cytochrome P450s are also able to catalyse the activation of compounds to toxic products, and participate in a variety of essential ...
Henderson, C J, Sahraouei, A, Wolf, C R
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Journal of Lipid Mediators and Cell Signalling, 1995
M L, Schwartzman, J C, McGiff
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M L, Schwartzman, J C, McGiff
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2008
PART A: Chapter 1: Cytochrome P450 Structure and Function: An Evolutionary Perspective Chapter 2: Generation of reactive intermediates by cytochromes P450 PART B: Chapter 3: The CYP1A subfamily Chapter 4: The CYP1B subfamily Chapter 5: The CYP2A subfamily Chapter 6: The CYP2B subfamily Chapter 7: The CYP2C subfamily Chapter 8: The CYP2D subfamily ...
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PART A: Chapter 1: Cytochrome P450 Structure and Function: An Evolutionary Perspective Chapter 2: Generation of reactive intermediates by cytochromes P450 PART B: Chapter 3: The CYP1A subfamily Chapter 4: The CYP1B subfamily Chapter 5: The CYP2A subfamily Chapter 6: The CYP2B subfamily Chapter 7: The CYP2C subfamily Chapter 8: The CYP2D subfamily ...
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