Results 101 to 110 of about 23,312 (291)

Structure of a bacterial cell surface decaheme electron conduit [PDF]

, 2011
Some bacterial species are able to utilize extracellular mineral forms of iron and manganese as respiratory electron acceptors. In Shewanella oneidensis this involves decaheme cytochromes that are located on the bacterial cell surface at the termini of ...
A. Hall, A. J. Gates, A. S. Beliaev, Adams, Bucking, C. L. Reardon, Collaborative Computational Project Number, D. J. Richardson, Einsle, Emsley, Field, Firer-Sherwood, G. F. White, Hartshorne, Igarashi, J. Bradley, J. K. Fredrickson, J. M. Zachara, J. N. Butt, Johs, L. Shi, Lies, M. J. Edwards, M. J. Marshall, McCoy, McLean, N. J. Watmough, Porollo, Ries, Ruebush, Sheldrick, Shi, Shi, T. A. Clarke, Z. Wang   +34 more
core   +3 more sources

Increasing the succinate yield in Actinobacillus succinogenes by fumigation of H2 in a bioreactor

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract The microbial conversion of CO2 into value‐added chemicals offers a promising and scalable route for sustainable bioproduction, particularly under mild reaction conditions and with technically straightforward reactor configurations. Actinobacillus succinogenes, a natural succinate producer, can fix CO2 through anaplerotic carboxylation but its
Julian Tix, Gustav Zimpel, Roland Ulber, Nils Tippkötter   +3 more
wiley   +1 more source

De novo biosynthesis of 8-hydroxyoctanoic acid via a medium-chain length specific fatty acid synthase and cytochrome P450 in Saccharomyces cerevisiae

Metabolic Engineering Communications, 2020
Terminally hydroxylated fatty acids or dicarboxylic acids are industrially relevant compounds with broad applications. Here, we present the proof of principle for the de novo biosynthesis of 8-hydroxyoctanoic acid from glucose and ethanol in the yeast ...
Florian Wernig, Eckhard Boles, Mislav Oreb   +2 more
doaj   +1 more source

An integrated biochemical system for nitrate assimilation and nitric oxide detoxification in Bradyrhizobium japonicum [PDF]

, 2016
Rhizobia are recognized to establish N(2)-fixing symbiotic interactions with legume plants. Bradyrhizobium japonicum, the symbiont of soybeans, can denitrify and grow under free-living conditions with nitrate (NO(3)(−)) or nitrite (NO(2)(−)) as sole ...
Alderton, Ana Salas, Andrew J. Gates, Angelo, Bates, Bedmar, Bedmar, Bergersen, Cabrera, Crutzen, David J. Richardson, Delgado, Delgado, Egelhoff, Eulogio J. Bedmar, Franck, Fukuda, Gardner, Gates, Gilberthorpe, Goddard, Hauser, Hernández-Urzúa, Horchani, Inaba, Juan J. Cabrera, Kaneko, Kartal, Kato, Kim, Lin, Luque-Almagro, Luque-Almagro, Maia, Maia, María J. Delgado, María J. Torres, Meakin, Meakin, Mesa, Miller, Mills, Moreno-Vivián, Moreno-Vivián, Nicholas, Pino, Pittman, Poole, Pullan, Ravishankara, Regensburger, Rinaldo, Robles, Rowley, Sambrook, Schinko, Simon, Spiro, Spiro, Sánchez, Sánchez, Sánchez, Tinajero-Trejo, Torres, Torres, Vargas, Velasco, Vine, Vine, Zumft   +69 more
core   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Bioreduction of Idarubicin and Formation of ROS Responsible for DNA Cleavage by NADPH-Cytochrome P450 Reductase and its Potential Role in the Antitumor Effect

Journal of Pharmacy & Pharmaceutical Sciences, 2009
PURPOSE. Idarubicin is a clinically effective synthetic anthracycline analog used in the treatment of several human neoplasms. Anthracyclines have the potential to undergo bioactivation by flavoenzymes to free radicals and thus exert their cytotoxic ...
Haydar Çelik, Emel Arinç
doaj   +1 more source

The "backdoor pathway" of androgen synthesis in human male sexual development. [PDF]

, 2019
Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a
Auchus, Richard J, Miller, Walter L
core   +2 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Cytochrome b5 reductase orchestrates IL-1β production in macrophages through FAD

Cell Death and Disease
The cytochrome-b5 reductases (CYB5Rs) regulate cellular redox balance and contribute to the pathogenesis of inflammatory diseases. However, the roles of CYB5R5 in macrophages remain poorly understood and require further elucidation.
Jian Fu, Zhihua Liu, Hangchao Zhang, Xinmei Zhang, Shijie Liu, Xuehua Mei, Xiu Zeng, Wenkai Ren   +7 more
doaj   +1 more source

CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress [PDF]

, 2016
The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli. A cydD mutant strain was used to probe the influence of CydDC upon reduced thiol export, gene expression, metabolic perturbations, intracellular pH homeostasis, and ...
Cook, Gregory M, Holyoake, Louise V, Howard, Mark J., Hunt, Stuart, Poole, Robert K, Rowe, Michelle L., Sanguinetti, Guido, Shepherd, Mark   +7 more
core   +3 more sources