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The Role of Cytochromes P450 in Infection

open access: yesFrontiers in Immunology, 2018
Cytochromes are expressed in many different tissues of the human body. They are found mostly in intestinal and hepatic tissues. Cytochromes P450 (CYPs) are enzymes that oxidize substances using iron and are able to metabolize a large variety of ...
Elisávet Stavropoulou   +2 more
exaly   +4 more sources

Increased mutation rates and diversity are dominant features of Geobacter multiheme cytochromes [PDF]

open access: yesmBio
Multiheme cytochromes (MHCs) are the central catalysts of extracellular electron transfer and are uniquely abundant in the genomes of model Fe(III)-reducing organisms like Geobacter sulfurreducens.
Ruth Starwalt-Lee   +2 more
doaj   +2 more sources

Evolution for enhanced extracellular electron transfer in Geobacter sulfurreducens over seventeen years of continuous current generation [PDF]

open access: yesFrontiers in Microbiology
Bioelectrochemical systems that harvest electricity from wastes, soils, or sediments are designed to operate over long periods of time. However, little is known about the long-term adaptation of electroactive microbes to such non-natural environments ...
Dawn E. Holmes   +8 more
doaj   +2 more sources

Electron transport across the cell envelope via multiheme c-type cytochromes in Geobacter sulfurreducens [PDF]

open access: yesFrontiers in Chemistry
Extracellular electron transfer (EET) enables certain microorganisms to respire using soluble and insoluble extracellular electron acceptors by transporting electrons across the cell envelope. Among these, G. sulfurreducens serves as a model organism for
Media Zakizadeh Tabari   +1 more
doaj   +2 more sources

Activity of respiratory chain cytochrome complexes and cytochromes content in the rat kidney mitochondria under different nutrients content in a diet [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2023
An important role in ensuring the functioning of the respiratory chain belongs to the cytochrome part, which includes complexes III (ubiquinol-cytochrome c oxidoreductase) and IV (cytochrome c oxidase). The key components of these enzymatic complexes are
H. P. Kopylchuk, O. M. Voloshchuk
doaj   +1 more source

Ligand-Based Regulation of Dynamics and Reactivity of Hemoproteins

open access: yesBiomolecules, 2023
Hemoproteins include several heme-binding proteins with distinct structure and function. The presence of the heme group confers specific reactivity and spectroscopic properties to hemoproteins.
Emily Samuela Turilli-Ghisolfi   +2 more
doaj   +1 more source

Structure-function analysis of the heme-binding WWD domain in the bacterial holocytochrome c synthase, CcmFH

open access: yesmBio, 2023
Heme trafficking is a fundamental biological process, yet its direct study has been hampered due to heme’s tight intracellular regulation, heme cytotoxicity, and the transient nature of trafficking.
Amber L. Grunow   +3 more
doaj   +1 more source

Direct Observation of Electrically Conductive Pili Emanating from Geobacter sulfurreducens

open access: yesmBio, 2021
Geobacter sulfurreducens is a model microbe for elucidating the mechanisms for extracellular electron transfer in several biogeochemical cycles, bioelectrochemical applications, and microbial metal corrosion.
Xinying Liu   +4 more
doaj   +1 more source

Co-fitness analysis identifies a diversity of signal proteins involved in the utilization of specific c-type cytochromes

open access: yesAnnals of Microbiology, 2022
Purpose c-Type cytochromes are essential for extracellular electron transfer (EET) in electroactive microorganisms. The expression of appropriate c-type cytochromes is an important feature of these microorganisms in response to different extracellular ...
De-wu Ding   +3 more
doaj   +1 more source

An Archaea-specific c-type cytochrome maturation machinery is crucial for methanogenesis in Methanosarcina acetivorans

open access: yeseLife, 2022
c-Type cytochromes (cyt c) are proteins that undergo post-translational modification to covalently bind heme, which allows them to facilitate redox reactions in electron transport chains across all domains of life.
Dinesh Gupta   +2 more
doaj   +1 more source

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