Results 41 to 50 of about 33,784 (307)

Expression and Clinical Significance of Cytochrome 1B1 in Bone Sarcomas

Pharmaceuticals
Background/Objectives: Cytochrome 1B1 (CYP1B1) is overexpressed in several cancers, contributing to carcinogenesis, cancer progression, and chemoresistance. Despite its known oncogenic role, its expression in bone sarcomas remains unknown.
Belal Al-zu’bi, Fatemah OFO Alshammari, Randa AlQaisi, Jaber H. Jaradat, Marwan Herzallah, Mohannad Ja’Awin, Anas O. Satari, Yousef M. Al-saraireh, Mohammad Salem Hareedy   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

QNA-Based Prediction of Sites of Metabolism

Molecules, 2017
Metabolism of xenobiotics (Greek xenos: exogenous substances) plays an essential role in the prediction of biological activity and testing for the subsequent research and development of new drug candidates.
Olga Tarasova, Anastassia Rudik, Alexander Dmitriev, Alexey Lagunin, Dmitry Filimonov, Vladimir Poroikov   +5 more
doaj   +1 more source

Divergent Cytochrome c Maturation System in Kinetoplastid Protists

mBio, 2021
Cytochromes ...
Asma Belbelazi, Rachel Neish, Martin Carr, Jeremy C. Mottram, Michael L. Ginger   +4 more
doaj   +1 more source

Protein engineering of cytochromes P-450

, 2000
The cytochromes P-450 are an immensely important superfamily of heme-containing enzymes. They catalyze the monooxygenation of an enormous range of substrates.
Chapman, SK, Michael A Noble, Caroline S Miles, Tobias W.B Ost, Munro, Andrew, Stephen K Chapman, Miles, Caroline S, Miles, Caroline S., Andrew W Munro, Munro, Andrew W, Noble MA, Ost, Tobias W B, Noble, Michael A, Chapman, Stephen K   +13 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Deciphering Molecular Factors That Affect Electron Transfer at the Cell Surface of Electroactive Bacteria: The Case of OmcA from Shewanella oneidensis MR-1

Microorganisms, 2022
Multiheme cytochromes play a central role in extracellular electron transfer, a process that allows microorganisms to sustain their metabolism with external electron acceptors or donors.
Ricardo O. Louro, Giovanni Rusconi, Bruno M. Fonseca, Catarina M. Paquete   +3 more
doaj   +1 more source

The structure of protozoan cytochromes [PDF]

, 1974
C-type cytochromes from two protozoa, Crithidia oncopelti and Kuglena gracilis. were purified and partly characterised. Crithidia cytochrome C557 and Euglena cytochrome C558 had certain atypical spectral characteristics. The sequence of amino acids in
Pettigrew, Graham Walter
core  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The Small RNA RyhB Is a Regulator of Cytochrome Expression in Shewanella oneidensis

Frontiers in Microbiology, 2018
Shewanella oneidensis produces an extensive electron transfer network that results in metabolic flexibility. A large number of c-type cytochromes are expressed by S.
Karin L. Meibom, Elena M. Cabello, Rizlan Bernier-Latmani   +2 more
doaj   +1 more source