Results 171 to 180 of about 22,374,088 (435)

Overexpression of the protein kinase CK2 increases the survival and resistance to chemotherapy of acute myeloid leukemia cells [PDF]

, 2013
Background: The critical role of protein kinase CK2 in the regulation of cellular apoptosis suggests its may be involvement in tumor cell resistance to both conventional and unconventional therapies.
PAVAN, LAURA
core   +1 more source

Unraveling genotype–phenotype associations and predictive modeling of outcome in acute myeloid leukemia

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Acute myeloid leukemia (AML) comprises 32% of adult leukemia cases, with a 5‐year survival rate of only 20–30%. Here, the immunophenotypic landscape of this heterogeneous malignancy is explored in a single‐center cohort using a novel quantitative computational pipeline.
Artuur Couckuyt, Sofie Van Gassen, Annelies Emmaneel, Vince Janda, Malicorne Buysse, Ine Moors, Jan Philippé, Mattias Hofmans, Tessa Kerre, Yvan Saeys, Sarah Bonte   +10 more
wiley   +1 more source

Genomic and cytogenetic analysis of the Ceratitis capitata temperature-sensitive lethal region. [PDF]

G3 (Bethesda), 2023
Sollazzo G, Gouvi G, Nikolouli K, Aumann RA, Djambazian H, Whitehead MA, Berube P, Chen SH, Tsiamis G, Darby AC, Ragoussis J, Schetelig MF, Bourtzis K.   +12 more
europepmc   +1 more source

Increased anti‐apoptotic (Bcl‐2+) and decreased proliferative (Ki‐67+) cell fractions during the different maturation stages of bone marrow cell populations in MDS and AML: The potential diagnostic impact of the Bcl‐2:Ki‐67 ratio

Cytometry Part B: Clinical Cytometry, Volume 108, Issue 2, Page 146-160, March 2025.
Abstract The relationship between apoptosis inhibition and cell proliferation was studied during the maturation stages of erythropoiesis, granulopoiesis, and monopoiesis in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The anti‐apoptotic and proliferative cell fractions were determined in bone marrow aspirates derived ...
Stefan G. C. Mestrum, Tom Schoenmakers, Sixuan J. Wang, Norbert C. J. de Wit, Bert T. Boonen, Wouter L. W. van Hemert, Ruben Deneer, Anton H. N. Hopman, Frans C. S. Ramaekers, Math P. G. Leers   +9 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Cytogenetic Analysis of Seven Species of Gekkonid and Phyllodactylid Geckos. [PDF]

Genes (Basel), 2023
Chrostek G, Domaradzka A, Yurchenko A, Kratochvíl L, Mazzoleni S, Rovatsos M.   +5 more
europepmc   +1 more source

A cytogenetic analysis of the Punch-tudor region of chromosome 2R in Drosophila melanogaster. [PDF]

, 1989
Janis M. O’Donnell, Robert Boswell, Thomas Reynolds, William J. Mackay   +3 more
openalex   +1 more source

A strong internal promoter drives massive expression of YEATS‐domain devoid MLLT3 transcripts in HSC and most lethal AML

Cancer Communications, Volume 45, Issue 3, Page 380-385, March 2025.
Chloé Bessière, Ahmed Zamani, Romain Pfeifer, Sandra Dailhau, Camille Marchet, Benoit Guibert, Anthony Boureux, Raïssa Silva Da Silva, Nicolas Gilbert, Thérèse Commes, Fabienne Meggetto, Christian Touriol, Christian Récher, Marina Bousquet, Stéphane Pyronnet   +14 more
wiley   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

CYTOLOGICAL AND GENETIC CHARACTERIZATION OF A NEW MUTANT OF VEGETABLE PEPPER CAPSICUM ANNUUM VAR. ANNUUM L.

Вавиловский журнал генетики и селекции, 2015
Two new spontaneous mutations of the vegetable pepper C. annuum var. annuum have been identified in the 5-th insolation zone in a greenhouse. Tentative cytologic and genetic characterization shows that both were dominant and were controlled by two ...
O. Yu. Timin, O. O. Timina, P. Yu. Montvid, A. P. Samovol   +3 more
doaj