Results 321 to 330 of about 22,374,088 (435)

STAB1 Promotes Acute Myeloid Leukemia Progression by Activating the IKK/NF‐κB Pathway and Increasing M2 Macrophage Polarization

Cancer Science, EarlyView.
In this study, we explored the effects of silenced STAB1 expression in AML cells on the polarization of M2‐like macrophages, as well as the involvement of nuclear factor‐kappa B (NF‐κB) signaling pathways in the pro‐oncogenic roles of STAB1. By investigating the expression pattern of STAB1 along with its regulatory mechanisms in AML patients, we aimed ...
Jiaxiu Yin, Jing Luo, Lan Wang, Lanxiang Liu, Lin Liu   +4 more
wiley   +1 more source

Detection of residual host cells after bone marrow transplantation using non-isotopic in situ hybridization [PDF]

, 1993
Cremer, Thomas, Knuutila, Sakari, Popp, Susanne, Ruutu, Tapani, Volin, L., Wessman, M.   +5 more
core  

Pimitespib, an HSP90 Inhibitor, Enhances the Efficacy of PARP Inhibitors in PARP Inhibitor‐Insensitive Breast Cancer Cells

Cancer Science, EarlyView.
Pimitespib, an HSP90 inhibitor, enhances the antitumor activity of PARP inhibitors by impairing the homologous recombination (HR) repair pathway in PARP inhibitor‐insensitive breast cancer cells. This is achieved by promoting the downregulation of proteins involved in HR, such as BRCA1, BRCA2, and RAD51.
Hiromi Muraoka, Hiromi Kazuno, Akihiro Hashimoto, Hiroshi Sootome, Shuichi Ohkubo   +4 more
wiley   +1 more source

A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias [PDF]

, 2005
Benoit, Yves, BILLIET, J, BOOGAERTS, M, Cauwelier, Barbara, COOLS, J, DASTUGUE, N, De Moerloose, Barbara, De Paepe, Anne, GRAUX, C, HAGEMEIJER, A, HUGUET, F, MARYNEN, P, Poppe, Bruce, ROBERT, A, SELLESLAG, D, Speleman, Franki, UYTTEBROECK, A, Van Roy, Nadine, VANDENBERGHE, P, Vandesompele, Jo, Verhasselt, Bruno   +20 more
core  

Portuguese Society of Ophthalmology and Portuguese Society of Human Genetics Joint Clinical Practice Guidelines for Genetic Testing in Inherited Retinal Dystrophies

Clinical Genetics, Volume 107, Issue 6, Page 600-611, June 2025.
This study provides clinical practice guidelines to streamline genetic testing for inherited retinal dystrophies (IRDs), underscoring the critical role of molecular diagnosis in enhancing patient care. These recommendations aim to elevate diagnostic accuracy, guide therapeutic decisions, and ultimately improve patient outcomes, marking a significant ...
João Pedro Marques, Célia Azevedo Soares, Ana Luísa Carvalho, Sérgio Estrela‐Silva, Luísa Coutinho Santos, Lina Ramos, Eduardo Silva   +6 more
wiley   +1 more source

Molecular-cytogenetic analysis of diploid wheatgrass Thinopyrum bessarabicum (Savul. and Rayss) A. Löve. [PDF]

Comp Cytogenet, 2019
Badaeva ED, Surzhikov SA, Agafonov AV.
europepmc   +1 more source

A Case‐Driven Multi‐Omics Analysis for Longitudinal Ibrutinib Response Evaluation of Patients With Chronic Lymphocytic Leukemia

European Journal of Haematology, Volume 114, Issue 6, Page 973-981, June 2025.
ABSTRACT Patients with chronic lymphocytic leukemia (CLL) undergoing ibrutinib treatment often experience incomplete response, yet the molecular level underlying clonal inertia remains to be explored. We investigated the molecular and clinical dynamics of CLL during 16 months of ibrutinib monotherapy by analyzing blood samples from two patients who ...
Sólja Remisdóttir Veyhe, Marcus Høy Hansen, Oriane Cédile, Michael Boe Møller, Mie Kiszka Nielsen, Mads Thomassen, Karen Juul‐Jensen, Henrik Frederiksen, Karen Dybkær, Charlotte Guldborg Nyvold   +9 more
wiley   +1 more source

Outcomes of Melflufen Treatment in Patients With Relapsed/Refractory Multiple Myeloma

European Journal of Haematology, Volume 114, Issue 6, Page 982-989, June 2025.
ABSTRACT Objective Melphalan flufenamide (melflufen) plus dexamethasone is fully approved in Europe for patients with relapsed/refractory multiple myeloma (RRMM) with ≥ 3 prior lines of therapy. We analyzed the efficacy and safety of melflufen in the real‐world setting.
Shahrier Hossain, Clifton Mo, Sarah Patches, Houry Leblebjian, Kathryn Goodrich, Eileen Regan, Kathleen O'Neill, Kim Noonan, Paul G. Richardson, Jacob Laubach   +9 more
wiley   +1 more source

Limited clinical value of regular bone marrow cytogenetic analysis in imatinib-treated chronic phase CML patients monitored by RQ-PCR for BCR-ABL

Leukemia, 2006
D. Ross, S. Branford, S. Moore, T. Hughes   +3 more
semanticscholar   +1 more source

Therapeutic Strategies for Relapsed or Refractory B‐Cell Acute Lymphoblastic Leukemia in Adult Patients: Optimizing the Use of Monoclonal Antibodies

European Journal of Haematology, Volume 114, Issue 6, Page 938-952, June 2025.
ABSTRACT The treatment landscape for relapsed or refractory acute lymphoblastic leukemia (RR ALL) has evolved significantly with the introduction of monoclonal antibodies such as blinatumomab and inotuzumab ozogamicin. These agents have demonstrated remarkable efficacy, achieving high response rates and minimal residual disease (MRD) negativity ...
Antonella Bruzzese, Enrica Antonia Martino, Caterina Labanca, Giulio Caridà, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Noemi Puccio, Antonino Neri, Fortunato Morabito, Ernesto Vigna, Massimo Gentile   +11 more
wiley   +1 more source