Results 71 to 80 of about 22,374,088 (435)

ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways

Advanced Science, EarlyView.
Zinc‐finger MYND‐type‐containing 8 (ZMYND8) activates the transcription of CCAAT/enhancer‐binding protein epsilon by recognizing dimethylation of lysine 36 in histone H3 through its Pro‐Trp‐Trp‐Pro domain, thereby inhibiting adaptive unfolded protein response pathways to suppress the proliferation and invasion of multiple myeloma (MM) cells ...
Jiaxuan Xu, Xiaoqing Dong, Yue Peng, Jie Yan, Peipei Xu, Feiyu Li, Suwen Zhang, Lanxin Chen, Xingjun Meng, Kangning Wang, Mengying Xing, Wenyang Li, David C. S. Huang, Quan Zhao, Bing Chen   +14 more
wiley   +1 more source

Analysis of chromosomal abnormalities in patients with hematological malignancies in Isfahan population [PDF]

Journal of Advanced Biomedical Sciences, 2017
Background & Objectives: Numerical and structural chromosomal abnormalities are known to be associated with predisposition to hematologic malignancies development and even different response to treatment.
Hamid Ganji, Mansour Salehi, Alireza Moafi, Amin Izaditabar, Zakiye Nadeali, Mohamad Amin Honardost, Atefeh Baghersad, Akram Hashemian, Majid Hosseinzadeh   +8 more
doaj  

Immunophenotypic characterisation and cytogenetic analysis of mesenchymal stem cells from equine bone marrow and foal umbilical cords during in vitro culture

Journal of Veterinary Research, 2016
Introduction: The objective of the study was immunophenotypic and cytogenetic analysis of mesenchymal stem cells from equine bone marrow and foal umbilical cords during in vitro culture.
Mazurkevych Anatoliy, Malyuk Mykola, Bezdieniezhnykh Natalia, Starodub Lyubov, Kharkevych Yuriy, Brusko Evgen, Gryzińska Magdalena, Jakubczak Andrzej   +7 more
doaj   +1 more source

Cytogenetic analysis for research and services [PDF]

Journal of thee Medical Sciences (Berkala Ilmu Kedokteran), 2016
AbstractThat the correct chromosome number in man is 46 was first recognized by Tjio and Levan in 1956. Perhaps few Indonesians know that Tjio was an Indonesian scientist studying in Sweden and then living in the US. Cytogenetic analyses are commonly performed to determine both structural and numerical chromosome aberration, whilst changes in ...
openaire   +3 more sources

NF2 is Essential for Human Endoderm Development

Advanced Science, Volume 12, Issue 17, May 8, 2025.
This study demonstrates that NF2, moesin‐ezrin‐radixin like (MERLIN) tumor suppressor (NF2) is essential for human endoderm formation. NF2 knockout human induced pluripotent stem cells fail to form endoderm both in vitro and in vivo due to yes‐associated protein 1 (YAP1) nuclear translocation, redirecting differentiation toward myofibroblast‐like cells.
Minjin Jeong, Dongjun Han, Preetida Bhetariya, D. Bradley Welling, Miodrag Stojkovic, Konstantina M. Stankovic   +5 more
wiley   +1 more source

Molecular Cytogenetic Analysis of Telomere Rearrangements [PDF]

Current Protocols in Human Genetics, 2000
AbstractGenomic imbalances involving the telomeric regions of human chromosomes, which contain the highest gene concentration in the genome, are proposed to have severe phenotypic consequences. For this reason, it is important to identify telomere rearrangements and assess their contribution to human pathology.
Christa Lese Martin, David H. Ledbetter
openaire   +3 more sources

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Multiplex ligation-dependent probe amplification – a short overview

Romanian Journal of Laboratory Medicine, 2020
Multiplex Ligation-dependent Probe Amplification is a technique proposed for the detection of deletions or duplications that may lead to copy number variations in genomic DNA, mainly due to its higher resolution, and shorter overall diagnosis time, when ...
Moldovan Valeriu, Moldovan Elena
doaj   +1 more source

DLBCL-Morph: Morphological features computed using deep learning for an annotated digital DLBCL image set [PDF]

arXiv, 2020
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. Though histologically DLBCL shows varying morphologies, no morphologic features have been consistently demonstrated to correlate with prognosis. We present a morphologic analysis of histology sections from 209 DLBCL cases with associated clinical and cytogenetic data ...
arxiv  

Clinical findings associated with a de novo partial trisomy 10p11.22p15.3 and monosomy 7p22.3 detected by chromosomal microarray analysis. [PDF]

, 2011
We present the case of an 18-month-old boy with dysmorphic facial features, developmental delay, growth retardation, bilateral clubfeet, thrombocytopenia, and strabismus, whose array CGH analysis revealed concurrent de novo trisomy 10p11.22p15.3 and ...
Dipple, Katrina M, Kohannim, Omid, Peredo, Jane, Quintero-Rivera, Fabiola   +3 more
core   +2 more sources