Results 121 to 130 of about 88,615 (317)

IMPACT OF HIGH-RISK CYTOGENETICS ON THE SURVIVAL OF NON-APL ACUTE MYELOID LEUKEMIA PATIENTS

Hematology, Transfusion and Cell Therapy
Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the rapid proliferation of abnormal myeloid cells in the bone marrow and peripheral blood.
FMCP Pessoa, DS Oliveira, IV Barreto, AKC Machado, BMD Nogueira, CB Machado, RM Ribeiro, MOM Filho, MEA Moraes, CA Moreira-Nunes   +9 more
doaj  

Next-generation Sequencing and Karyotype Analysis for the Diagnosis of Robertsonian Translocation Type Trisomy 13: A Case Report

Iranian Journal of Public Health, 2017
Trisomy 13 (Patau syndrome) is the third most common autosomal trisomy with a prevalence between 1 in 10,000 - 20,000 live births. Robertsonian translocations represent the largest number of chromosomal aberrations in human population with an incidence ...
Jing SHA, Fumin LIU, Bei ZHANG, Yang HUANG, Qinglin ZHANG, Gao JUAN, Jingfang ZHAI   +6 more
doaj  

Fluorescence in situ hybridization improves the detection of 5q31 deletion in myelodysplastic syndromes without cytogenetic evidence of 5q-

Haematologica, 2008
Background More than 50% of patients with myelodysplastic syndromes present cytogenetic aberrations at diagnosis. Partial or complete deletion of the long arm of chromosome 5 is the most frequent abnormality.
Mar Mallo, Leonor Arenillas, Blanca Espinet, Marta Salido, Jesús Mª Hernández, Eva Lumbreras, Mónica del Rey, Eva Arranz, Soraya Ramiro, Patricia Font, Olga González, Mónica Renedo, José Cervera, Esperanza Such, Guillermo F. Sanz, Elisa Luño, Carmen Sanzo, Miriam González, María José Calasanz, José Mayans, Carlos García-Ballesteros, Victoria Amigo, Rosa Collado, Isabel Oliver, Félix Carbonell, Encarna Bureo, Andrés Insunza, Lucrecia Yañez, María José Muruzabal, Elena Gómez-Beltrán, Rafael Andreu, Pilar León, Valle Gómez, Ángeles Sanz, Natalia Casasola, Esperanza Moreno, Adrián Alegre, María Luisa Martín, Carmen Pedro, Sergi Serrano, Lourdes Florensa, Francesc Solé   +41 more
doaj   +1 more source

Exploring the Multifractal Behavior of the Human Genome T2T-CHM13v2.0: Graphical Representations and Cytogenetics [PDF]

arXiv
In this work, we applied the Chaos Game Representation (CGR) to the complete human genomic sequence T2T-CHM13v2.0, analyzing the entire chromosome assembly and each chromosome separately, including mitochondrial DNA. Multifractal spectra were determined using two types of box-counting coverage, revealing slight variations across most chromosomes. While
arxiv  

Dipteran chromosomes: a simple method for obtaining high quality chromosomal preparations [PDF]

, 2014
For cytogenetic studies it is necessary to develop an efficient method of chromosome preparation with wellpreserved and dispersed chromosomes and little or no cell-wall debris.
Bressa, Maria Jose, Chirino, Monica Gabriela, Luaces, Juan Pablo, Merani, Maria Susana, Rossi, Luis Francisco   +4 more
core  

ClearLLab 10C reagents panel can be applied to analyze paucicellular samples by flow cytometry

Cytometry Part B: Clinical Cytometry, Volume 108, Issue 2, Page 128-136, March 2025.
Abstract The FDA‐approved ClearLLab 10C Reagents Panel (Beckman Coulter) simplified the diagnosis of leukemias and lymphomas by flow cytometry. However, the requirement of using 3 × 106 cells/mL cannot be met for paucicellular samples. Therefore, we tested whether this 10‐color panel can be reliably employed to analyze specimens with low cell ...
Małgorzata Kajstura, Tia LaBarge, Andrew G. Evans   +2 more
wiley   +1 more source

FTIR spectral imaging as a probe of ultrasound effect on cells in vitro [PDF]

Biophys. & Bioeng. Letters (2009), Vol 2, Nr 2, 2010
Safe and efficient intracellular delivery of genes or drugs is critically important in targeted cancer treatment and gene therapy applications. Ultrasound (US) has been demonstrated to alter the cell membrane permeability due to a biophysical mechanism (Sonoporation) and exploited as a promising non-invasive gene transfer method.
arxiv  

Focus on the Holdrinet index: Toward blast quantification by flow cytometry

Cytometry Part B: Clinical Cytometry, Volume 108, Issue 2, Page 137-145, March 2025.
Abstract Blast quantification in the bone marrow (BM) is crucial for evaluating myeloid neoplasms, with cytomorphology being the only recognized analysis. The CD34 myeloid cell (CD34M) count by flow cytometry is promising but impaired by BM hemodilution.
Edouard Bonneville, Marie‐Christine Jacob, Simon Chevalier, Martine Pernollet, Chantal Dumestre‐Perard, Giovanna Clavarino   +5 more
wiley   +1 more source

Unraveling genotype–phenotype associations and predictive modeling of outcome in acute myeloid leukemia

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Acute myeloid leukemia (AML) comprises 32% of adult leukemia cases, with a 5‐year survival rate of only 20–30%. Here, the immunophenotypic landscape of this heterogeneous malignancy is explored in a single‐center cohort using a novel quantitative computational pipeline.
Artuur Couckuyt, Sofie Van Gassen, Annelies Emmaneel, Vince Janda, Malicorne Buysse, Ine Moors, Jan Philippé, Mattias Hofmans, Tessa Kerre, Yvan Saeys, Sarah Bonte   +10 more
wiley   +1 more source

Correction to: Novel deletion of exon 3 in TYR gene causing Oculocutaneous albinism 1B in an Indian family along with intellectual disability associated with chromosomal copy number variations

BMC Medical Genomics, 2022
Somprakash Dhangar, Purvi Panchal, Jagdeeshwar Ghatanatti, Jitendra Suralkar, Anjali Shah, Babu Rao Vundinti   +5 more
doaj   +1 more source