Results 301 to 310 of about 132,265 (338)
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Neurochemical Research, 1990
Interphase cytogenetics is still in its infancy but the information which it is capable of providing will lead to a greater understanding not only of the normal interphase nucleus but also of the genetic content of tumor cells and will facilitate antenatal diagnosis of some hereditary diseases.
Herrington, C. S., McGhee, J. O'D.
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Interphase cytogenetics is still in its infancy but the information which it is capable of providing will lead to a greater understanding not only of the normal interphase nucleus but also of the genetic content of tumor cells and will facilitate antenatal diagnosis of some hereditary diseases.
Herrington, C. S., McGhee, J. O'D.
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British Medical Bulletin, 1961
May I begin by recalling that at the Copenhagen Conference five years ago, Tjio and Levan had just published their almost apologetic announcement that they could only find 46 chromosomes in cultured human somatic cells, and Hamerton and I presented evidence that there were 23 bivalents in spermatocytes, not 24.Since that time there has been a very ...
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May I begin by recalling that at the Copenhagen Conference five years ago, Tjio and Levan had just published their almost apologetic announcement that they could only find 46 chromosomes in cultured human somatic cells, and Hamerton and I presented evidence that there were 23 bivalents in spermatocytes, not 24.Since that time there has been a very ...
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Clinics in Laboratory Medicine, 2011
Lymphomas are a heterogeneous group of neoplasms with distinct morphologic, immunologic, and cytogenetic characteristics. Overlapping morphologic and immunophenotypic features often makes accurate diagnosis difficult. Cytogenetics helps simplify the diagnostic complexities presented in transforming and progressive lymphoid malignancies. Genetic studies
Bhavana J, Dave +2 more
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Lymphomas are a heterogeneous group of neoplasms with distinct morphologic, immunologic, and cytogenetic characteristics. Overlapping morphologic and immunophenotypic features often makes accurate diagnosis difficult. Cytogenetics helps simplify the diagnostic complexities presented in transforming and progressive lymphoid malignancies. Genetic studies
Bhavana J, Dave +2 more
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Seminars in Pediatric Neurology, 2001
In the past decade, clinical cytogenetics has undergone remarkable advancement as molecular biology techniques have been applied to conventional chromosome analysis. The limitations of conventional banding analysis in the accurate diagnosis and interpretation of certain chromosome abnormalities have largely been overcome by these new technologies ...
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In the past decade, clinical cytogenetics has undergone remarkable advancement as molecular biology techniques have been applied to conventional chromosome analysis. The limitations of conventional banding analysis in the accurate diagnosis and interpretation of certain chromosome abnormalities have largely been overcome by these new technologies ...
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Cytogenetic and molecular cytogenetic findings in lipoblastoma
Cancer Genetics and Cytogenetics, 2008Lipoblastoma is a rare benign tumor that arises from embryonic adipose tissue and usually occurs in young children. Here, we present a review of available cytogenetic data and the karyotypes of 10 new cases of lipoblastoma, of which 7 could be studied further by fluorescence in situ hybridization (FISH) with regard to the involvement of the PLAG1 gene.
Hammurabi, Bartuma +5 more
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Current Biology, 1992
Chromosome variants are well established as useful genetic markers and integral components both of the genetic structure of populations, and in speciation. The current explosion of molecular techniques is facilitating the localization of many DNA sequences, while a reassessment of the fitness of chromosome mutants challenges some classical views on ...
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Chromosome variants are well established as useful genetic markers and integral components both of the genetic structure of populations, and in speciation. The current explosion of molecular techniques is facilitating the localization of many DNA sequences, while a reassessment of the fitness of chromosome mutants challenges some classical views on ...
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2003
The establishment of reliable and meaningful chromosomal (cytogenetic, karyotypic) changes in hematological disorders, primarily the leukemias and lymphomas, must be based on the examination of the involved cells or tissues. Thus, in the case of the leukemias bone marrow (BM) aspirations yield optimal results in the preponderant number of patients ...
A A, Sandberg, Z, Chen
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The establishment of reliable and meaningful chromosomal (cytogenetic, karyotypic) changes in hematological disorders, primarily the leukemias and lymphomas, must be based on the examination of the involved cells or tissues. Thus, in the case of the leukemias bone marrow (BM) aspirations yield optimal results in the preponderant number of patients ...
A A, Sandberg, Z, Chen
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Cytogenetics and molecular cytogenetics in prenatal diagnosis
Clinics in Laboratory Medicine, 2003Prenatal chromosome diagnosis has been a rapidly changing field over the past 10 years for both sampling methodologies and molecular techniques to complement chromosome analysis. This review summarizes current techniques used by the clinician and their risks, and selected aspects of cytogenetic and molecular techniques used by the laboratories.
Alan E, Donnenfeld, Allen N, Lamb
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Cytogenetics and molecular cytogenetics in multiple myeloma
European Journal of Cancer, 2006Multiple myeloma (MM) is characterized by frequent and complex genomic abnormalities that not only essentially contribute to the pathogenesis of this disease but also reflect its prognostic heterogeneity. There is evidence for two more or less mutually exclusive oncogenic pathways in the early development of clonal plasma cell disorders.
Peter, Liebisch, Hartmut, Döhner
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Pathobiology, 1990
Applications of flow karyotype analysis and flow chromosome sorting are being developed and are becoming increasingly relevant to clinical research. Among these applications are the quantitative analysis of chromosomal DNA content changes enabling the detection of minute deletions or unbalanced translocations, the quantitative analysis of aneuploidy ...
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Applications of flow karyotype analysis and flow chromosome sorting are being developed and are becoming increasingly relevant to clinical research. Among these applications are the quantitative analysis of chromosomal DNA content changes enabling the detection of minute deletions or unbalanced translocations, the quantitative analysis of aneuploidy ...
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